A Practical Approach to the Diagnosis of Melanocytic Lesions

Research output: Contribution to journalArticle

Abstract

Context.-Melanocytic lesions are common in routine surgical pathology. Although the majority of these lesions can be confidently diagnosed using well-established morphologic criteria, there is a significant subset of lesions that can be diagnostically difficult. These can be a source of anxiety for patients, clinicians, and pathologists, and the potential consequences of a missed diagnosis of melanoma are serious.

Objective.-To provide a practical approach to the diagnosis of melanocytic lesions, including classic problem areas as well as suggestions for common challenges and appropriate incorporation of ancillary molecular techniques.

Data Sources.-Literature search using PubMed and Google Scholar, incorporating numerous search terms relevant to the particular section, combined with contemporaneous texts and lessons from personal experience.

Conclusions.-Although a subset of melanocytic lesions can be diagnostically challenging, the combination of a methodical approach to histologic assessment, knowledge of potential diagnostic pitfalls, opinions from trusted colleagues, and judicious use of ancillary techniques can help the pathologist navigate this difficult area.

Original languageEnglish
Pages (from-to)789-810
Number of pages22
JournalARCHIVES OF PATHOLOGY & LABORATORY MEDICINE
Volume143
Issue number7
DOIs
Publication statusPublished - Jul 2019

Cite this

@article{0946137cfd5b4790a7a78c44f4786b43,
title = "A Practical Approach to the Diagnosis of Melanocytic Lesions",
abstract = "Context.-Melanocytic lesions are common in routine surgical pathology. Although the majority of these lesions can be confidently diagnosed using well-established morphologic criteria, there is a significant subset of lesions that can be diagnostically difficult. These can be a source of anxiety for patients, clinicians, and pathologists, and the potential consequences of a missed diagnosis of melanoma are serious.Objective.-To provide a practical approach to the diagnosis of melanocytic lesions, including classic problem areas as well as suggestions for common challenges and appropriate incorporation of ancillary molecular techniques.Data Sources.-Literature search using PubMed and Google Scholar, incorporating numerous search terms relevant to the particular section, combined with contemporaneous texts and lessons from personal experience.Conclusions.-Although a subset of melanocytic lesions can be diagnostically challenging, the combination of a methodical approach to histologic assessment, knowledge of potential diagnostic pitfalls, opinions from trusted colleagues, and judicious use of ancillary techniques can help the pathologist navigate this difficult area.",
keywords = "LYMPH-NODE BIOPSY, IN-SITU HYBRIDIZATION, ATYPICAL SPITZ TUMORS, CELLULAR BLUE NEVUS, SUN-DAMAGED SKIN, PIGMENTED EPITHELIOID MELANOCYTOMA, COMPARATIVE GENOMIC HYBRIDIZATION, MOLECULAR CYTOGENETIC ANALYSIS, COPY NUMBER VARIATIONS, ANIMAL-TYPE MELANOMA",
author = "Harvey, {Nathan T.} and Wood, {Benjamin A.}",
year = "2019",
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doi = "10.5858/arpa.2017-0547-RA",
language = "English",
volume = "143",
pages = "789--810",
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publisher = "College of American Pathologists",
number = "7",

}

A Practical Approach to the Diagnosis of Melanocytic Lesions. / Harvey, Nathan T.; Wood, Benjamin A.

In: ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE, Vol. 143, No. 7, 07.2019, p. 789-810.

Research output: Contribution to journalArticle

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AB - Context.-Melanocytic lesions are common in routine surgical pathology. Although the majority of these lesions can be confidently diagnosed using well-established morphologic criteria, there is a significant subset of lesions that can be diagnostically difficult. These can be a source of anxiety for patients, clinicians, and pathologists, and the potential consequences of a missed diagnosis of melanoma are serious.Objective.-To provide a practical approach to the diagnosis of melanocytic lesions, including classic problem areas as well as suggestions for common challenges and appropriate incorporation of ancillary molecular techniques.Data Sources.-Literature search using PubMed and Google Scholar, incorporating numerous search terms relevant to the particular section, combined with contemporaneous texts and lessons from personal experience.Conclusions.-Although a subset of melanocytic lesions can be diagnostically challenging, the combination of a methodical approach to histologic assessment, knowledge of potential diagnostic pitfalls, opinions from trusted colleagues, and judicious use of ancillary techniques can help the pathologist navigate this difficult area.

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