A population-based study of age-related variation in clinicopathological features, molecular markers and outcome from colorectal cancer

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Abstract

Background: To investigate age-related differences in clinicopathological features, molecular alterations and patient survival in a large, population -based series of CRC. Patients and Methods: The study cohort consisted of 5,971 cases diagnosed between 1993 and 2003 representing over 90% of the CRCs diagnosed in the state of Western Australia. Results: Patients aged <= 30, <= 40, <= 50 and <= 60 years comprised 0.9%, 3.1%, 10.6% and 27.8% of all cases, respectively. The proportion of rectal cancers and tumors with poor differentiation was higher in <= 30-year-old patients and decreased progressively with age. The incidence of tumors with microsatellite instability was significantly higher inpatients aged <= 40 years (18.3%) compared to those aged 41-60 years (6.6%; p < 0.0001). TP53 mutations were also more frequent (p=0.002), however K-ras mutations were less common (p = 0.0001) when comparing the same age groups. Conclusion: These results provide evidence for major age-related differences in the clinical and molecular features of CRC.
Original languageEnglish
Pages (from-to)2833-2838
JournalAnticancer Research
Volume27
Issue number4c
Publication statusPublished - 2007

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Colorectal Neoplasms
Rectal Neoplasms
Population
Microsatellite Instability
Western Australia
Mutation
Inpatients
Cohort Studies
Age Groups
Survival
Incidence
Neoplasms

Cite this

@article{23fbf7da35ec454c88581b7ca9ee309f,
title = "A population-based study of age-related variation in clinicopathological features, molecular markers and outcome from colorectal cancer",
abstract = "Background: To investigate age-related differences in clinicopathological features, molecular alterations and patient survival in a large, population -based series of CRC. Patients and Methods: The study cohort consisted of 5,971 cases diagnosed between 1993 and 2003 representing over 90{\%} of the CRCs diagnosed in the state of Western Australia. Results: Patients aged <= 30, <= 40, <= 50 and <= 60 years comprised 0.9{\%}, 3.1{\%}, 10.6{\%} and 27.8{\%} of all cases, respectively. The proportion of rectal cancers and tumors with poor differentiation was higher in <= 30-year-old patients and decreased progressively with age. The incidence of tumors with microsatellite instability was significantly higher inpatients aged <= 40 years (18.3{\%}) compared to those aged 41-60 years (6.6{\%}; p < 0.0001). TP53 mutations were also more frequent (p=0.002), however K-ras mutations were less common (p = 0.0001) when comparing the same age groups. Conclusion: These results provide evidence for major age-related differences in the clinical and molecular features of CRC.",
author = "Melinda Morris and Cameron Platell and Barry Iacopetta",
year = "2007",
language = "English",
volume = "27",
pages = "2833--2838",
journal = "Anticancer Research",
issn = "0250-7005",
publisher = "International Institute of Anticancer Research",
number = "4c",

}

TY - JOUR

T1 - A population-based study of age-related variation in clinicopathological features, molecular markers and outcome from colorectal cancer

AU - Morris, Melinda

AU - Platell, Cameron

AU - Iacopetta, Barry

PY - 2007

Y1 - 2007

N2 - Background: To investigate age-related differences in clinicopathological features, molecular alterations and patient survival in a large, population -based series of CRC. Patients and Methods: The study cohort consisted of 5,971 cases diagnosed between 1993 and 2003 representing over 90% of the CRCs diagnosed in the state of Western Australia. Results: Patients aged <= 30, <= 40, <= 50 and <= 60 years comprised 0.9%, 3.1%, 10.6% and 27.8% of all cases, respectively. The proportion of rectal cancers and tumors with poor differentiation was higher in <= 30-year-old patients and decreased progressively with age. The incidence of tumors with microsatellite instability was significantly higher inpatients aged <= 40 years (18.3%) compared to those aged 41-60 years (6.6%; p < 0.0001). TP53 mutations were also more frequent (p=0.002), however K-ras mutations were less common (p = 0.0001) when comparing the same age groups. Conclusion: These results provide evidence for major age-related differences in the clinical and molecular features of CRC.

AB - Background: To investigate age-related differences in clinicopathological features, molecular alterations and patient survival in a large, population -based series of CRC. Patients and Methods: The study cohort consisted of 5,971 cases diagnosed between 1993 and 2003 representing over 90% of the CRCs diagnosed in the state of Western Australia. Results: Patients aged <= 30, <= 40, <= 50 and <= 60 years comprised 0.9%, 3.1%, 10.6% and 27.8% of all cases, respectively. The proportion of rectal cancers and tumors with poor differentiation was higher in <= 30-year-old patients and decreased progressively with age. The incidence of tumors with microsatellite instability was significantly higher inpatients aged <= 40 years (18.3%) compared to those aged 41-60 years (6.6%; p < 0.0001). TP53 mutations were also more frequent (p=0.002), however K-ras mutations were less common (p = 0.0001) when comparing the same age groups. Conclusion: These results provide evidence for major age-related differences in the clinical and molecular features of CRC.

M3 - Article

VL - 27

SP - 2833

EP - 2838

JO - Anticancer Research

JF - Anticancer Research

SN - 0250-7005

IS - 4c

ER -