Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 2833-2838 |
| Journal | Anticancer Research |
| Volume | 27 |
| Issue number | 4c |
| Publication status | Published - 2007 |
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A population-based study of age-related variation in clinicopathological features, molecular markers and outcome from colorectal cancer. / Morris, Melinda; Platell, Cameron; Iacopetta, Barry.
In: Anticancer Research, Vol. 27, No. 4c, 2007, p. 2833-2838.Research output: Contribution to journal › Article
TY - JOUR
T1 - A population-based study of age-related variation in clinicopathological features, molecular markers and outcome from colorectal cancer
AU - Morris, Melinda
AU - Platell, Cameron
AU - Iacopetta, Barry
PY - 2007
Y1 - 2007
N2 - Background: To investigate age-related differences in clinicopathological features, molecular alterations and patient survival in a large, population -based series of CRC. Patients and Methods: The study cohort consisted of 5,971 cases diagnosed between 1993 and 2003 representing over 90% of the CRCs diagnosed in the state of Western Australia. Results: Patients aged <= 30, <= 40, <= 50 and <= 60 years comprised 0.9%, 3.1%, 10.6% and 27.8% of all cases, respectively. The proportion of rectal cancers and tumors with poor differentiation was higher in <= 30-year-old patients and decreased progressively with age. The incidence of tumors with microsatellite instability was significantly higher inpatients aged <= 40 years (18.3%) compared to those aged 41-60 years (6.6%; p < 0.0001). TP53 mutations were also more frequent (p=0.002), however K-ras mutations were less common (p = 0.0001) when comparing the same age groups. Conclusion: These results provide evidence for major age-related differences in the clinical and molecular features of CRC.
AB - Background: To investigate age-related differences in clinicopathological features, molecular alterations and patient survival in a large, population -based series of CRC. Patients and Methods: The study cohort consisted of 5,971 cases diagnosed between 1993 and 2003 representing over 90% of the CRCs diagnosed in the state of Western Australia. Results: Patients aged <= 30, <= 40, <= 50 and <= 60 years comprised 0.9%, 3.1%, 10.6% and 27.8% of all cases, respectively. The proportion of rectal cancers and tumors with poor differentiation was higher in <= 30-year-old patients and decreased progressively with age. The incidence of tumors with microsatellite instability was significantly higher inpatients aged <= 40 years (18.3%) compared to those aged 41-60 years (6.6%; p < 0.0001). TP53 mutations were also more frequent (p=0.002), however K-ras mutations were less common (p = 0.0001) when comparing the same age groups. Conclusion: These results provide evidence for major age-related differences in the clinical and molecular features of CRC.
M3 - Article
VL - 27
SP - 2833
EP - 2838
JO - Anticancer Research
JF - Anticancer Research
SN - 0250-7005
IS - 4c
ER -