TY - JOUR
T1 - A population-based longitudinal study of Clostridium difficile infection-related hospitalization in mid-age and older Australians
AU - Chen, Y.
AU - Glass, K.
AU - Liu, B.
AU - Riley, T. V.
AU - Korda, R.
AU - Kirk, M. D.
PY - 2017/2/1
Y1 - 2017/2/1
N2 - SUMMARY Clostridium difficile is the principal cause of infectious diarrhoea in hospitalized patients. We investigated the incidence and risk factors for hospitalization due to C. difficile infection (CDI) in older Australians. We linked data from a population-based prospective cohort study (the 45 and Up Study) of 266 922 adults aged ≥45 years recruited in New South Wales, Australia to hospitalization and death records for 2006-2012. We estimated the incidence of CDI hospitalization and calculated days in hospital and costs per hospitalization. We also estimated hazard ratios (HR) for CDI hospitalization using Cox regression with age as the underlying time variable. Over a total follow-up of 1 126 708 person-years, 187 adults had an incident CDI hospitalization. The crude incidence of CDI hospitalization was 16 6/100 000 person-years, with a median hospital stay of 6 days, and a median cost of AUD 6102 per admission. Incidence increased with age and year of follow-up, with a threefold increase for 2009-2012. After adjustment, CDI hospitalization rates were significantly lower in males than females (adjusted HR 0 6, 95% confidence interval 0 4-0 7). CDI hospitalization rates increased significantly over 2009-2012. There is a need to better understand the increasing risk of CDI hospitalization in women. © Cambridge University Press 2016
AB - SUMMARY Clostridium difficile is the principal cause of infectious diarrhoea in hospitalized patients. We investigated the incidence and risk factors for hospitalization due to C. difficile infection (CDI) in older Australians. We linked data from a population-based prospective cohort study (the 45 and Up Study) of 266 922 adults aged ≥45 years recruited in New South Wales, Australia to hospitalization and death records for 2006-2012. We estimated the incidence of CDI hospitalization and calculated days in hospital and costs per hospitalization. We also estimated hazard ratios (HR) for CDI hospitalization using Cox regression with age as the underlying time variable. Over a total follow-up of 1 126 708 person-years, 187 adults had an incident CDI hospitalization. The crude incidence of CDI hospitalization was 16 6/100 000 person-years, with a median hospital stay of 6 days, and a median cost of AUD 6102 per admission. Incidence increased with age and year of follow-up, with a threefold increase for 2009-2012. After adjustment, CDI hospitalization rates were significantly lower in males than females (adjusted HR 0 6, 95% confidence interval 0 4-0 7). CDI hospitalization rates increased significantly over 2009-2012. There is a need to better understand the increasing risk of CDI hospitalization in women. © Cambridge University Press 2016
KW - Clostridium difficile
KW - epidemiology
UR - http://www.scopus.com/inward/record.url?scp=84992426917&partnerID=8YFLogxK
U2 - 10.1017/S0950268816002260
DO - 10.1017/S0950268816002260
M3 - Article
C2 - 27780483
AN - SCOPUS:84992426917
VL - 145
SP - 575
EP - 582
JO - Epidemiology and Infection
JF - Epidemiology and Infection
SN - 0950-2688
IS - 3
ER -