A Parallelized Pumpless Artificial Placenta System Significantly Prolonged Survival Time in a Preterm Lamb Model

Yuichiro Miura; T. Matsuda; H. Usuda; S. Watanabe; R. Kitanishi; M. Saito; T. Hanita; Y. Kobayashi

doi:10.1111/aor.12656

A Parallelized Pumpless Artificial Placenta System Significantly Prolonged Survival Time in a Preterm Lamb Model

Yuichiro Miura, T. Matsuda, H. Usuda, S. Watanabe, R. Kitanishi, M. Saito, T. Hanita, Y. Kobayashi

Research output: Contribution to journal › Article › peer-review

43 Citations (Scopus)

Abstract

© 2016 Wiley Periodicals, Inc. and International Center for Artificial Organs and Transplantation. An artificial placenta (AP) is an arterio-venous extracorporeal life support system that is connected to the fetal circulation via the umbilical vasculature. Previously, we published an article describing a pumpless AP system with a small priming volume. We subsequently developed a parallelized system, hypothesizing that the reduced circuit resistance conveyed by this modification would enable healthy fetal survival time to be prolonged. We conducted experiments using a premature lamb model to test this hypothesis. As a result, the fetal survival period was significantly prolonged (60.4±3.8 vs. 18.2±3.2h, P

Original language	English
Pages (from-to)	E61-E68
Journal	Artificial Organs
Volume	40
Issue number	5
DOIs	https://doi.org/10.1111/aor.12656
Publication status	Published - 1 May 2016

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abstract = "{\textcopyright} 2016 Wiley Periodicals, Inc. and International Center for Artificial Organs and Transplantation. An artificial placenta (AP) is an arterio-venous extracorporeal life support system that is connected to the fetal circulation via the umbilical vasculature. Previously, we published an article describing a pumpless AP system with a small priming volume. We subsequently developed a parallelized system, hypothesizing that the reduced circuit resistance conveyed by this modification would enable healthy fetal survival time to be prolonged. We conducted experiments using a premature lamb model to test this hypothesis. As a result, the fetal survival period was significantly prolonged (60.4±3.8 vs. 18.2±3.2h, P",

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AU - Watanabe, S.

AU - Kitanishi, R.

AU - Saito, M.

AU - Hanita, T.

AU - Kobayashi, Y.

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A Parallelized Pumpless Artificial Placenta System Significantly Prolonged Survival Time in a Preterm Lamb Model

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