A Parallelized Pumpless Artificial Placenta System Significantly Prolonged Survival Time in a Preterm Lamb Model

Yuichiro Miura, T. Matsuda, H. Usuda, S. Watanabe, R. Kitanishi, M. Saito, T. Hanita, Y. Kobayashi

    Research output: Contribution to journalArticle

    19 Citations (Scopus)

    Abstract

    © 2016 Wiley Periodicals, Inc. and International Center for Artificial Organs and Transplantation. An artificial placenta (AP) is an arterio-venous extracorporeal life support system that is connected to the fetal circulation via the umbilical vasculature. Previously, we published an article describing a pumpless AP system with a small priming volume. We subsequently developed a parallelized system, hypothesizing that the reduced circuit resistance conveyed by this modification would enable healthy fetal survival time to be prolonged. We conducted experiments using a premature lamb model to test this hypothesis. As a result, the fetal survival period was significantly prolonged (60.4±3.8 vs. 18.2±3.2h, P
    Original languageEnglish
    Pages (from-to)E61-E68
    JournalArtificial Organs
    Volume40
    Issue number5
    DOIs
    Publication statusPublished - 2016

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