Abstract
A one-pot, three-component method incorporating a domino Heck-aza-Michael reaction has been developed for the rapid synthesis of functionalised tetrahydroisoquinolines. Following the in situ generation of an acrylamide, a domino process involving intermolecular Heck reaction and subsequent intramolecular aza-Michael addition affords tetrahydroisoquinolines bearing C1-acetamide functionality.
Original language | English |
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Pages (from-to) | 1632-1635 |
Journal | European Journal of Organic Chemistry |
Volume | 2011 |
DOIs | |
Publication status | Published - 2011 |