A One-Pot, Three-Component Approach to Functionalised Tetrahydroisoquinolines Using Domino Heck-aza-Michael Reactions

D.L. Priebbenow, F.M. Pfeffer, Scott Stewart

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

A one-pot, three-component method incorporating a domino Heck-aza-Michael reaction has been developed for the rapid synthesis of functionalised tetrahydroisoquinolines. Following the in situ generation of an acrylamide, a domino process involving intermolecular Heck reaction and subsequent intramolecular aza-Michael addition affords tetrahydroisoquinolines bearing C1-acetamide functionality.
Original languageEnglish
Pages (from-to)1632-1635
JournalEuropean Journal of Organic Chemistry
Volume2011
DOIs
Publication statusPublished - 2011

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