TY - JOUR
T1 - A novel sulfate-bridged binuclear copper(ii) complex
T2 - structure, optical, ADMET andin vivoapproach in a murine model of bone metastasis
AU - Hchicha, Khouloud
AU - Korb, Marcus
AU - Badraoui, Riadh
AU - Naïli, Houcine
PY - 2021/8/21
Y1 - 2021/8/21
N2 - The novel sulfate-bridged binuclear copper(ii) complex namely [Cu2(μ3-SO4)2(C4H6N2)4] (1) was obtained from the hydrothermal reaction of 2-methylimidazole (hereafter abbreviated as 2-MeIm) with copper(ii) sulfate pentahydrate in methanol. Single-crystal X-ray diffraction analysis of1(space groupP1̄; cell parameters:a= 8.5712(6) Å,b= 8.7884(10) Å,c= 9.8797(6) Å,α= 115.22(1)°,β= 97.26(1)°,γ= 108.82(1)° andV= 606.26(12) Å3) revealed the formation of a centrosymmetric dimeric species. Therein, two [Cu(C4H6N2)2] moieties are connectedviatwo sulfate anions in a μ-1κ2O1,O2,2κO3fashion and resulting in a tricyclo[5.1.13,5] structure. The Cu atom adopts a distorted square pyramidal coordination geometry (τ= 19). Hydrogen bonds between the imidazole amino groups and non-coordinating sulfato oxygen atoms result in a two-dimensional network parallel to (010). To accumulate a greater knowledge on how molecular components engage with their local environment, a Hirshfeld surface (HS) analysis employing 3D molecular surface contours and 2D fingerprint plots have been undertaken. Heating of1above 89 °C initiates gradual decomposition stages, which lead to the metal oxide as a final product at 720 °C, as proven by TGA/DSC analysis. UV-visible spectroscopy was exploited to determine bandgap energy and the nature of the electron transition.In vivo, the synthesized complex showed significant ameliorative effects on tumor osteolytic lesions in malignant Walker 256/B breast cancer-induced bone metastases.
AB - The novel sulfate-bridged binuclear copper(ii) complex namely [Cu2(μ3-SO4)2(C4H6N2)4] (1) was obtained from the hydrothermal reaction of 2-methylimidazole (hereafter abbreviated as 2-MeIm) with copper(ii) sulfate pentahydrate in methanol. Single-crystal X-ray diffraction analysis of1(space groupP1̄; cell parameters:a= 8.5712(6) Å,b= 8.7884(10) Å,c= 9.8797(6) Å,α= 115.22(1)°,β= 97.26(1)°,γ= 108.82(1)° andV= 606.26(12) Å3) revealed the formation of a centrosymmetric dimeric species. Therein, two [Cu(C4H6N2)2] moieties are connectedviatwo sulfate anions in a μ-1κ2O1,O2,2κO3fashion and resulting in a tricyclo[5.1.13,5] structure. The Cu atom adopts a distorted square pyramidal coordination geometry (τ= 19). Hydrogen bonds between the imidazole amino groups and non-coordinating sulfato oxygen atoms result in a two-dimensional network parallel to (010). To accumulate a greater knowledge on how molecular components engage with their local environment, a Hirshfeld surface (HS) analysis employing 3D molecular surface contours and 2D fingerprint plots have been undertaken. Heating of1above 89 °C initiates gradual decomposition stages, which lead to the metal oxide as a final product at 720 °C, as proven by TGA/DSC analysis. UV-visible spectroscopy was exploited to determine bandgap energy and the nature of the electron transition.In vivo, the synthesized complex showed significant ameliorative effects on tumor osteolytic lesions in malignant Walker 256/B breast cancer-induced bone metastases.
UR - http://www.scopus.com/inward/record.url?scp=85112396110&partnerID=8YFLogxK
U2 - 10.1039/d1nj02388h
DO - 10.1039/d1nj02388h
M3 - Article
AN - SCOPUS:85112396110
SN - 1144-0546
VL - 45
SP - 13775
EP - 13784
JO - New Journal of Chemistry
JF - New Journal of Chemistry
IS - 31
ER -
