© 2016Pseudo random number generator (PRNG) based hardware cryptographic architecture is presented in quantum-dot cellular automata (QCA) technology. Major achievement is the production of cipher texts using random number generator instead of fixed keys. The random ciphers thus generated reduce the detection probability. A novel algorithm for cipher text design has been provided in this paper. In a bottom-up approach, we have designed all the architectural components which include QCA based XOR block, 4-bit Counter, 4 to 16 Decoder, Memory Elements and two PRNG blocks. Finally a synchronized integration of the individual components led to the generation of a novel cryptographic architecture. This design has achieved two layers of security. First layer is ensured by the encryption scheme, which has been achieved by the PRNGs and XOR block and the second layer is achieved by a Permutation Block at the transmission end. An effective and innovative cryptographic scheme compared to the existing works is proposed here.