A novel preclinical biopsy technique and new insights into a rare subtype of paediatric ependymoma

Sasha Rogers

Research output: ThesisMaster's Thesis

Abstract

Ependymoma represents the third most common brain tumour in the paediatric population. Contemporary management is based on gross total surgical resection and adjuvant chemo-radiotherapy. To date no chemotherapy has improved on overall survival. New insights into the underlying molecular drivers have enabled the design of more accurate animal models that recapitulate the human disease. This overview provides a look into paediatric ependymoma and the way in which translational research is advancing more target-specific appraoches to its management. A novel technique of serial brain tissue biopsy in glioma mouse models is presented.
LanguageEnglish
QualificationMasters
Awarding Institution
  • The University of Western Australia
Supervisors/Advisors
  • Cole, Catherine, Supervisor
  • Dallas, Peter, Supervisor
  • Endersby, Raelene, Supervisor
  • Gottardo, Nicholas, Supervisor
  • Lee, Sharon, Supervisor
Award date18 Feb 2018
DOIs
StatePublished - 2018

Fingerprint

Ependymoma
Pediatrics
Biopsy
Adjuvant Radiotherapy
Translational Medical Research
Brain Neoplasms
Glioma
Animal Models
Drug Therapy
Survival
Brain
Population

Cite this

@phdthesis{3336cb6fb1b240098b28254d134d6df0,
title = "A novel preclinical biopsy technique and new insights into a rare subtype of paediatric ependymoma",
abstract = "Ependymoma represents the third most common brain tumour in the paediatric population. Contemporary management is based on gross total surgical resection and adjuvant chemo-radiotherapy. To date no chemotherapy has improved on overall survival. New insights into the underlying molecular drivers have enabled the design of more accurate animal models that recapitulate the human disease. This overview provides a look into paediatric ependymoma and the way in which translational research is advancing more target-specific appraoches to its management. A novel technique of serial brain tissue biopsy in glioma mouse models is presented.",
keywords = "Translational research, Paediatric ependymoma, Mouse models, Brain tumour",
author = "Sasha Rogers",
year = "2018",
doi = "10.4225/23/5ac2e7106e2e9",
language = "English",
school = "The University of Western Australia",

}

A novel preclinical biopsy technique and new insights into a rare subtype of paediatric ependymoma. / Rogers, Sasha.

2018.

Research output: ThesisMaster's Thesis

TY - THES

T1 - A novel preclinical biopsy technique and new insights into a rare subtype of paediatric ependymoma

AU - Rogers,Sasha

PY - 2018

Y1 - 2018

N2 - Ependymoma represents the third most common brain tumour in the paediatric population. Contemporary management is based on gross total surgical resection and adjuvant chemo-radiotherapy. To date no chemotherapy has improved on overall survival. New insights into the underlying molecular drivers have enabled the design of more accurate animal models that recapitulate the human disease. This overview provides a look into paediatric ependymoma and the way in which translational research is advancing more target-specific appraoches to its management. A novel technique of serial brain tissue biopsy in glioma mouse models is presented.

AB - Ependymoma represents the third most common brain tumour in the paediatric population. Contemporary management is based on gross total surgical resection and adjuvant chemo-radiotherapy. To date no chemotherapy has improved on overall survival. New insights into the underlying molecular drivers have enabled the design of more accurate animal models that recapitulate the human disease. This overview provides a look into paediatric ependymoma and the way in which translational research is advancing more target-specific appraoches to its management. A novel technique of serial brain tissue biopsy in glioma mouse models is presented.

KW - Translational research

KW - Paediatric ependymoma

KW - Mouse models

KW - Brain tumour

U2 - 10.4225/23/5ac2e7106e2e9

DO - 10.4225/23/5ac2e7106e2e9

M3 - Master's Thesis

ER -