A novel fingerprint map for detecting SARS-CoV

Lei Gao, Y. Ding, H. Dai, S. Shao, Zhengde Huang, K. Chou

    Research output: Contribution to journalArticlepeer-review

    26 Citations (Scopus)


    Spike (S) protein is the most important membrane protein on the surface of severe acute respiratory syndrome coronavirus (SARS-CoV). It associates with cellular receptors to mediate infection of their target cells. Inspired by such a mechanism, an in-depth investigation into the genome sequences of S protein of SARS-CoV and its receptor are conducted thru a mathematical transformation and graphic approach. As an outcome, anovel method for visualizing the characteristic of SARS-CoV is suggested. An extensive comparison among a large number of genome sequences has proved that the characteristic thus revealed is unique for SARS-CoV. As such, the characteristic can be regarded as the fingerprintmap of SARS-CoV for diagnostic usage. Moreover, the conclusion has been further supported in a real case in Guangdong province of China. The fingerprintmap proposed here has the merits of clear visibility and reliability that can serve as a complementary clinical tool for detectingSARS-CoV, particularly for the cases where the results obtained by the conventional methods are uncertain or conflicted with each other.
    Original languageEnglish
    Pages (from-to)246-250
    JournalJournal of Pharmaceutical and Biomedical Analysis
    Issue number1
    Publication statusPublished - 2006


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