A novel antimicrobial hydrogel for the management of periodontal diseases: Antimicrobial Hydrogel to treat Periodontitis

Pauline Wong, Shane Soo, Edmund Wong, Praveen Praveen, Peta Clode, Murray Baker, Victor Haruo Matsubara

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Objectives: This study aimed to synthesise a drug-delivery system based on a porous polymer hydrogel, with antimicrobial properties against Porphyromonas gingivalis and potential to be used in tissue regeneration.

Material and methods:
2-Hydroxyethyl methacrylate monomers were polymerised using thermal and photoactivation in the presence of silver nitrate (AgNO3) and/or chlorhexidine digluconate. Poly-2-hydroxyethyl methacrylate (pHEMA) hydrogels containing silver nanoparticles (AgNPs) and/or 0.12% chlorhexidine (CHX) were produced and characterised using cryo-SEM and confocal microscopy. Hydrogel degradation and leaching of AgNP were tested for 1.5 months. The antimicrobial properties were tested against P. gingivalis using broth culture system and disk diffusion tests.

Results:
Our methodology manufactured porous polymeric hydrogels doped with AgNPs and CHX. Hydrogels showed a successful delivery of CHX and sustainable release of AgNPs in a steady hydrogel degradation rate determined based on the weight loss of samples. Hydrogels with AgNPs or CHX had a significant antimicrobial effect against P. gingivalis, with CHX-hydrogels exhibiting a stronger effect than AgNP-hydrogels in the short-term assessment. AgNP-CHX hydrogels showed a compounded antimicrobial effect, whereas control hydrogels containing neither AgNPs nor CHX had no influence on bacterial growth(P < .05).

Conclusions:
The dual-cured pHEMA hydrogel loaded with antimicrobial agents proved to bean efficient drug-delivery system against periodontopathogens, with the potential to be used as a scaffold for tissue regeneration.
Original languageEnglish
Pages (from-to)354-361
Number of pages8
JournalInternational Dental Journal
Volume73
Issue number3
DOIs
Publication statusPublished - Jun 2023

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