A Non-Volatile Pro-Dicamba Herbicide Inspired by Meclofenoxate

Joel Haywood; Karen J. Breese; M. Jordi Muria-Gonzalez; Kalia Bernath-Levin; Mark Waters; Keith A. Stubbs; Joshua S. Mylne

doi:10.1002/chem.202404282

A Non-Volatile Pro-Dicamba Herbicide Inspired by Meclofenoxate

Joel Haywood, Karen J. Breese, M. Jordi Muria-Gonzalez, Kalia Bernath-Levin, Mark Waters, Keith A. Stubbs, Joshua S. Mylne

Research output: Contribution to journal › Article › peer-review

Abstract

Dicamba is a popular herbicide with rising use but is also notorious for volatility drift. Inspired by meclofenoxate, which we show to be highly herbicidal, we developed a derivative of dicamba with an ester-bond to 2-dimethylaminoethanol. It remained herbicidal but is non-volatile, entering plants intact and hydrolyzing inside leaves to dicamba and 2-dimethylaminoethanol. This pro-dicamba is compatible with the relatively novel dicamba monooxygenase tolerance technology, suggesting pro-dicamba might be a suitable, non-volatile replacement for dicamba.

Original language	English
Article number	e202404282
Number of pages	4
Journal	Chemistry - A European Journal
DOIs	https://doi.org/10.1002/chem.202404282
Publication status	E-pub ahead of print - 8 Jan 2025

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10.1002/chem.202404282Licence: CC BY-NC-ND

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title = "A Non-Volatile Pro-Dicamba Herbicide Inspired by Meclofenoxate",

abstract = "Dicamba is a popular herbicide with rising use but is also notorious for volatility drift. Inspired by meclofenoxate, which we show to be highly herbicidal, we developed a derivative of dicamba with an ester-bond to 2-dimethylaminoethanol. It remained herbicidal but is non-volatile, entering plants intact and hydrolyzing inside leaves to dicamba and 2-dimethylaminoethanol. This pro-dicamba is compatible with the relatively novel dicamba monooxygenase tolerance technology, suggesting pro-dicamba might be a suitable, non-volatile replacement for dicamba.",

keywords = "Arabidopsis, Dicamba, Herbicides, Volatility drift",

author = "Joel Haywood and Breese, {Karen J.} and {Jordi Muria-Gonzalez}, M. and Kalia Bernath-Levin and Mark Waters and Stubbs, {Keith A.} and Mylne, {Joshua S.}",

note = "Publisher Copyright: {\textcopyright} 2025 The Author(s). Chemistry - A European Journal published by Wiley-VCH GmbH.",

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T1 - A Non-Volatile Pro-Dicamba Herbicide Inspired by Meclofenoxate

AU - Haywood, Joel

AU - Breese, Karen J.

AU - Jordi Muria-Gonzalez, M.

AU - Bernath-Levin, Kalia

AU - Waters, Mark

AU - Stubbs, Keith A.

AU - Mylne, Joshua S.

PY - 2025/1/8

Y1 - 2025/1/8

N2 - Dicamba is a popular herbicide with rising use but is also notorious for volatility drift. Inspired by meclofenoxate, which we show to be highly herbicidal, we developed a derivative of dicamba with an ester-bond to 2-dimethylaminoethanol. It remained herbicidal but is non-volatile, entering plants intact and hydrolyzing inside leaves to dicamba and 2-dimethylaminoethanol. This pro-dicamba is compatible with the relatively novel dicamba monooxygenase tolerance technology, suggesting pro-dicamba might be a suitable, non-volatile replacement for dicamba.

AB - Dicamba is a popular herbicide with rising use but is also notorious for volatility drift. Inspired by meclofenoxate, which we show to be highly herbicidal, we developed a derivative of dicamba with an ester-bond to 2-dimethylaminoethanol. It remained herbicidal but is non-volatile, entering plants intact and hydrolyzing inside leaves to dicamba and 2-dimethylaminoethanol. This pro-dicamba is compatible with the relatively novel dicamba monooxygenase tolerance technology, suggesting pro-dicamba might be a suitable, non-volatile replacement for dicamba.

KW - Arabidopsis

KW - Dicamba

KW - Herbicides

KW - Volatility drift

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SN - 0947-6539

JO - Chemistry - A European Journal

JF - Chemistry - A European Journal

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ER -

A Non-Volatile Pro-Dicamba Herbicide Inspired by Meclofenoxate

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Putting new herbicide targets on the table

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A Non-Volatile Pro-Dicamba Herbicide Inspired by Meclofenoxate

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Putting new herbicide targets on the table

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