A non-isotopic method for the detection of telomerase activity in tumour tissues: TRAP-silver staining assay

Jianming Wen, Laibao Sun, Meng Zhang, M. H. Zheng

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)

Abstract

Telomerase activity has been observed in a high proportion of specimens from a wide variety of human malignant tumours, but not in non-neoplastic tissues. Measurement of telomerase activity is a possible diagnostic maker for malignant tumours. A non-isotopic telomeric repeat amplification protocol (TRAP) silver staining method for the detection of telomerase activity in human bone tumour tissues is described. The TRAP-silver staining method was quick, safe, and effective, and can be used as a routine diagnostic method for the detection of telomerase activity in bone tumours.

Original languageEnglish
Pages (from-to)110-112
Number of pages3
JournalJournal of Clinical Pathology - Molecular Pathology
Volume51
Issue number2
DOIs
Publication statusPublished - 1998

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