A new strategy for vascular complications in young people with type 1 diabetes mellitus

on behalf of the Adolescent type 1 Diabetes cardio-renal Intervention Trial (AdDIT) study group

Research output: Contribution to journalArticle

Abstract

Diabetes vascular complications, including cardiovascular disease, diabetic nephropathy and retinopathy, have a negative effect on the long-term prognosis of young people with type 1 diabetes mellitus (T1DM). Poor glycaemic control and consequent increased HbA1c levels are major risk factors for the development of vascular complications. HbA1c levels are the main focus of current management strategies; however, the recommended target is rarely achieved in adolescents. Thus, a clear need exists for improved biomarkers to identify high-risk young people early and to develop new intervention strategies. Evidence is accumulating that early increases in urinary albumin excretion could be predictive of adolescents with T1DM who are at an increased risk of developing vascular complications, independent of HbA1c levels. These findings present an opportunity to move towards the personalized care of adolescents with T1DM, which takes into consideration changes in albumin excretion and other risk factors in addition to HbA1c levels.

Original languageEnglish
Pages (from-to)429-435
Number of pages7
JournalNature Reviews Endocrinology
Volume15
Issue number7
DOIs
Publication statusPublished - 1 Jul 2019

Fingerprint

Type 1 Diabetes Mellitus
Blood Vessels
Albumins
Diabetic Nephropathies
Diabetic Retinopathy
Diabetes Complications
Cardiovascular Diseases
Biomarkers

Cite this

on behalf of the Adolescent type 1 Diabetes cardio-renal Intervention Trial (AdDIT) study group (2019). A new strategy for vascular complications in young people with type 1 diabetes mellitus. Nature Reviews Endocrinology, 15(7), 429-435. https://doi.org/10.1038/s41574-019-0198-2
on behalf of the Adolescent type 1 Diabetes cardio-renal Intervention Trial (AdDIT) study group. / A new strategy for vascular complications in young people with type 1 diabetes mellitus. In: Nature Reviews Endocrinology. 2019 ; Vol. 15, No. 7. pp. 429-435.
@article{9e52e5779a69497ab19f44cbc53cf635,
title = "A new strategy for vascular complications in young people with type 1 diabetes mellitus",
abstract = "Diabetes vascular complications, including cardiovascular disease, diabetic nephropathy and retinopathy, have a negative effect on the long-term prognosis of young people with type 1 diabetes mellitus (T1DM). Poor glycaemic control and consequent increased HbA1c levels are major risk factors for the development of vascular complications. HbA1c levels are the main focus of current management strategies; however, the recommended target is rarely achieved in adolescents. Thus, a clear need exists for improved biomarkers to identify high-risk young people early and to develop new intervention strategies. Evidence is accumulating that early increases in urinary albumin excretion could be predictive of adolescents with T1DM who are at an increased risk of developing vascular complications, independent of HbA1c levels. These findings present an opportunity to move towards the personalized care of adolescents with T1DM, which takes into consideration changes in albumin excretion and other risk factors in addition to HbA1c levels.",
author = "{on behalf of the Adolescent type 1 Diabetes cardio-renal Intervention Trial (AdDIT) study group} and Marcovecchio, {M. Loredana} and Dalton, {R. Neil} and Denis Daneman and John Deanfield and Jones, {Timothy W.} and Neil, {H. Andrew W.} and Dunger, {David B.}",
year = "2019",
month = "7",
day = "1",
doi = "10.1038/s41574-019-0198-2",
language = "English",
volume = "15",
pages = "429--435",
journal = "Nature Reviews Endocrinology",
issn = "1745-8366",
publisher = "Nature Publishing Group",
number = "7",

}

on behalf of the Adolescent type 1 Diabetes cardio-renal Intervention Trial (AdDIT) study group 2019, 'A new strategy for vascular complications in young people with type 1 diabetes mellitus' Nature Reviews Endocrinology, vol. 15, no. 7, pp. 429-435. https://doi.org/10.1038/s41574-019-0198-2

A new strategy for vascular complications in young people with type 1 diabetes mellitus. / on behalf of the Adolescent type 1 Diabetes cardio-renal Intervention Trial (AdDIT) study group.

In: Nature Reviews Endocrinology, Vol. 15, No. 7, 01.07.2019, p. 429-435.

Research output: Contribution to journalArticle

TY - JOUR

T1 - A new strategy for vascular complications in young people with type 1 diabetes mellitus

AU - on behalf of the Adolescent type 1 Diabetes cardio-renal Intervention Trial (AdDIT) study group

AU - Marcovecchio, M. Loredana

AU - Dalton, R. Neil

AU - Daneman, Denis

AU - Deanfield, John

AU - Jones, Timothy W.

AU - Neil, H. Andrew W.

AU - Dunger, David B.

PY - 2019/7/1

Y1 - 2019/7/1

N2 - Diabetes vascular complications, including cardiovascular disease, diabetic nephropathy and retinopathy, have a negative effect on the long-term prognosis of young people with type 1 diabetes mellitus (T1DM). Poor glycaemic control and consequent increased HbA1c levels are major risk factors for the development of vascular complications. HbA1c levels are the main focus of current management strategies; however, the recommended target is rarely achieved in adolescents. Thus, a clear need exists for improved biomarkers to identify high-risk young people early and to develop new intervention strategies. Evidence is accumulating that early increases in urinary albumin excretion could be predictive of adolescents with T1DM who are at an increased risk of developing vascular complications, independent of HbA1c levels. These findings present an opportunity to move towards the personalized care of adolescents with T1DM, which takes into consideration changes in albumin excretion and other risk factors in addition to HbA1c levels.

AB - Diabetes vascular complications, including cardiovascular disease, diabetic nephropathy and retinopathy, have a negative effect on the long-term prognosis of young people with type 1 diabetes mellitus (T1DM). Poor glycaemic control and consequent increased HbA1c levels are major risk factors for the development of vascular complications. HbA1c levels are the main focus of current management strategies; however, the recommended target is rarely achieved in adolescents. Thus, a clear need exists for improved biomarkers to identify high-risk young people early and to develop new intervention strategies. Evidence is accumulating that early increases in urinary albumin excretion could be predictive of adolescents with T1DM who are at an increased risk of developing vascular complications, independent of HbA1c levels. These findings present an opportunity to move towards the personalized care of adolescents with T1DM, which takes into consideration changes in albumin excretion and other risk factors in addition to HbA1c levels.

UR - http://www.scopus.com/inward/record.url?scp=85064619374&partnerID=8YFLogxK

U2 - 10.1038/s41574-019-0198-2

DO - 10.1038/s41574-019-0198-2

M3 - Article

VL - 15

SP - 429

EP - 435

JO - Nature Reviews Endocrinology

JF - Nature Reviews Endocrinology

SN - 1745-8366

IS - 7

ER -

on behalf of the Adolescent type 1 Diabetes cardio-renal Intervention Trial (AdDIT) study group. A new strategy for vascular complications in young people with type 1 diabetes mellitus. Nature Reviews Endocrinology. 2019 Jul 1;15(7):429-435. https://doi.org/10.1038/s41574-019-0198-2