A new prognostic model for FIGO stage 1 epithelial ovarian cancer

A. Obermair, E. Lopez-Varela, T. Van Gorp, I. Vergote, L. Eaton, J. Fowler, M. Quinn, Ian Hammond, D. Marsden, A. Proietto, J. Carter, M. Davy, L. Tripcony, N. Abu-Rustum, A. Fuller

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    28 Citations (Scopus)


    Background. No consensus exists which patients with surgical stage I epithelial ovarian should receive postoperative chemotherapy. The purpose of this study was to evaluate the prognostic impact of preoperative CA-125 and to establish a prognostic index to identify patients in different risk categories.Methods. Data of 600 surgically staged patients with FIGO stage 1 EOC treated in eleven gynecological cancer centers in Australia, the USA and Europe were analyzed. Eligible patients include those with invasive EOC where a preoperative CA-125 was obtained and standard surgical staging performed. Overall survival (OS) was chosen as study endpoint. Preoperative CA-125 values were compared with other prognostic factors, and univariate and multivariate Cox models were calculated.Results. Two hundred and one patients (33.5%) had preoperative CA-125 <= 30 U/ml and CA-125 levels <= 30 U/ml were associated with lower grade,substage IA and mucinous histologic cell type. Patients with elevated CA-125 levels were more likely to receive chemotherapy. OS probability was 95% and 85% for patients with pretreatment CA-125 <= 30 U/ml and > 30 U/ml, respectively (p 0.003). Multivariate analysis confirmed preoperative serum CA-125 > 30 U/ml (OR 2.7) and age at diagnosis > 70 years (OR 2.6) as the only independent predictors for overall survival.Conclusion. Pretreatment of CA-125 <= 30 U/ml dominates over histologic cell type, substage and grade to identify a subgroup of FIGO stage I patients with a genuinely good prognosis with extremely good survival and who could possibly be spared with adjuvant chemotherapy. (c) 2006 Elsevier Inc. All rights reserved.
    Original languageEnglish
    Pages (from-to)607-611
    JournalGynecologic Oncology
    Issue number3
    Publication statusPublished - 2007


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