TY - JOUR
T1 - A new phylogenetic protocol: dealing with model misspecification and confirmation bias in molecular phylogenetics
AU - Jermiin, Lars
AU - Catullo, Renee
AU - Holland, Barbara
PY - 2020/6/1
Y1 - 2020/6/1
N2 - Molecular phylogenetics plays a key role in comparative genomics and has increasingly significant impacts on science, industry, government, public health and society. In this paper, we posit that the current phylogenetic protocol is missing two critical steps, and that their absence allows model misspecification and confirmation bias to unduly influence phylogenetic estimates. Based on the potential offered by well-established but under-used procedures, such as assessment of phylogenetic assumptions and tests of goodness of fit, we introduce a new phylogenetic protocol that will reduce confirmation bias and increase the accuracy of phylogenetic estimates.
AB - Molecular phylogenetics plays a key role in comparative genomics and has increasingly significant impacts on science, industry, government, public health and society. In this paper, we posit that the current phylogenetic protocol is missing two critical steps, and that their absence allows model misspecification and confirmation bias to unduly influence phylogenetic estimates. Based on the potential offered by well-established but under-used procedures, such as assessment of phylogenetic assumptions and tests of goodness of fit, we introduce a new phylogenetic protocol that will reduce confirmation bias and increase the accuracy of phylogenetic estimates.
U2 - 10.1093/nargab/lqaa041
DO - 10.1093/nargab/lqaa041
M3 - Comment/debate
C2 - 33575594
VL - 2
JO - NAR Genomics and Bioinformatics
JF - NAR Genomics and Bioinformatics
SN - 2631-9268
IS - 2
M1 - lqaa041
ER -
