A new measure of decompression sickness in the rat

Peter Buzzacott, Aleksandra Mazur, Qiong Wang, Kate Lambrechts, Michael Theron, Jacques Mansourati, François Guerrero

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Abstract

In this study we assessed the reliability of a tilting-board grip score as a measure of decompression sickness in rats. In experiments using a hyperbaric compression/decompression protocol, rats were observed for signs of decompression sickness and their grip strength measured on a tilting particle board hinged to a metal frame. Angles at which rats lost grip were converted to gravitational vectors. Decreased mean grip scores following decompression were fitted to a logistic regression model with strain, age, and weight. Decrease in grip score was significantly associated with observed decompression sickness (P=0.0036). The log odds ratio for decompression sickness = 1.40 (decrease in grip score). In rats with no decrease in mean grip score there was a 50% probability of decompression sickness (pDCS). This increased steadily with decreases in mean grip score. A decrease of 0.3 had a 60% pDCS, a decrease of 0.6 had a 70% pDCS, and a decrease of 2.1 had a 95% pDCS. The tilting board grip score is a reliable measure of the probability of decompression sickness.

Original languageEnglish
Article number123581
JournalBioMed Research International
Volume2014
DOIs
Publication statusPublished - 2014

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Buzzacott, P., Mazur, A., Wang, Q., Lambrechts, K., Theron, M., Mansourati, J., & Guerrero, F. (2014). A new measure of decompression sickness in the rat. BioMed Research International, 2014, [123581]. https://doi.org/10.1155/2014/123581