A new bioactive compound from the roots of Petasites hybridus

F. Khaleghi, L. Bin Din, F.R. Charati, W.A. Yaacob, M.A. Khalilzadeh, Brian Skelton, Mohamed Makha

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Abstract

A new benzofuran derivative (1) was isolated from the roots of Petasites hybridus and its structure was determined as 1-(6-hydroxy-2-isopropenyl-1-benzofuran-5-yl)-1-ethanone by spectroscopic data and X-ray crystallographic analysis. The compound 1 showed moderate inhibitory activity on human breast cancer MCF-7 cells proliferation in vitro with an IC50 value of 48 mu mol/L. The interaction of bovine serum albumin (BSA) and DNA with compound 1 were studied in an aqueous solution under physiological conditions by UV-vis spectroscopy. (C) 2011 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.
Original languageEnglish
Pages (from-to)254-258
JournalPhytochemistry Letters
Volume4
DOIs
Publication statusPublished - 2011

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Khaleghi, F., Bin Din, L., Charati, F. R., Yaacob, W. A., Khalilzadeh, M. A., Skelton, B., & Makha, M. (2011). A new bioactive compound from the roots of Petasites hybridus. Phytochemistry Letters, 4, 254-258. https://doi.org/10.1016/j.phytol.2011.04.009