A new benzofuran derivative (1) was isolated from the roots of Petasites hybridus and its structure was determined as 1-(6-hydroxy-2-isopropenyl-1-benzofuran-5-yl)-1-ethanone by spectroscopic data and X-ray crystallographic analysis. The compound 1 showed moderate inhibitory activity on human breast cancer MCF-7 cells proliferation in vitro with an IC50 value of 48 mu mol/L. The interaction of bovine serum albumin (BSA) and DNA with compound 1 were studied in an aqueous solution under physiological conditions by UV-vis spectroscopy. (C) 2011 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.
Khaleghi, F., Bin Din, L., Charati, F. R., Yaacob, W. A., Khalilzadeh, M. A., Skelton, B., & Makha, M. (2011). A new bioactive compound from the roots of Petasites hybridus. Phytochemistry Letters, 4, 254-258. https://doi.org/10.1016/j.phytol.2011.04.009