A new bioactive compound from the roots of Petasites hybridus

F. Khaleghi; L. Bin Din; F.R. Charati; W.A. Yaacob; M.A. Khalilzadeh; Brian Skelton; Mohamed Makha

doi:10.1016/j.phytol.2011.04.009

A new bioactive compound from the roots of Petasites hybridus

F. Khaleghi, L. Bin Din, F.R. Charati, W.A. Yaacob, M.A. Khalilzadeh, Brian Skelton, Mohamed Makha

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Abstract

A new benzofuran derivative (1) was isolated from the roots of Petasites hybridus and its structure was determined as 1-(6-hydroxy-2-isopropenyl-1-benzofuran-5-yl)-1-ethanone by spectroscopic data and X-ray crystallographic analysis. The compound 1 showed moderate inhibitory activity on human breast cancer MCF-7 cells proliferation in vitro with an IC50 value of 48 mu mol/L. The interaction of bovine serum albumin (BSA) and DNA with compound 1 were studied in an aqueous solution under physiological conditions by UV-vis spectroscopy. (C) 2011 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.

Original language	English
Pages (from-to)	254-258
Journal	Phytochemistry Letters
Volume	4
DOIs	https://doi.org/10.1016/j.phytol.2011.04.009
Publication status	Published - 2011

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10.1016/j.phytol.2011.04.009

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title = "A new bioactive compound from the roots of Petasites hybridus",

abstract = "A new benzofuran derivative (1) was isolated from the roots of Petasites hybridus and its structure was determined as 1-(6-hydroxy-2-isopropenyl-1-benzofuran-5-yl)-1-ethanone by spectroscopic data and X-ray crystallographic analysis. The compound 1 showed moderate inhibitory activity on human breast cancer MCF-7 cells proliferation in vitro with an IC50 value of 48 mu mol/L. The interaction of bovine serum albumin (BSA) and DNA with compound 1 were studied in an aqueous solution under physiological conditions by UV-vis spectroscopy. (C) 2011 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.",

author = "F. Khaleghi and {Bin Din}, L. and F.R. Charati and W.A. Yaacob and M.A. Khalilzadeh and Brian Skelton and Mohamed Makha",

year = "2011",

doi = "10.1016/j.phytol.2011.04.009",

language = "English",

volume = "4",

pages = "254--258",

journal = "Phytochemistry Letters",

issn = "1874-3900",

publisher = "Elsevier",

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TY - JOUR

T1 - A new bioactive compound from the roots of Petasites hybridus

AU - Khaleghi, F.

AU - Bin Din, L.

AU - Charati, F.R.

AU - Yaacob, W.A.

AU - Khalilzadeh, M.A.

AU - Skelton, Brian

AU - Makha, Mohamed

PY - 2011

Y1 - 2011

N2 - A new benzofuran derivative (1) was isolated from the roots of Petasites hybridus and its structure was determined as 1-(6-hydroxy-2-isopropenyl-1-benzofuran-5-yl)-1-ethanone by spectroscopic data and X-ray crystallographic analysis. The compound 1 showed moderate inhibitory activity on human breast cancer MCF-7 cells proliferation in vitro with an IC50 value of 48 mu mol/L. The interaction of bovine serum albumin (BSA) and DNA with compound 1 were studied in an aqueous solution under physiological conditions by UV-vis spectroscopy. (C) 2011 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.

AB - A new benzofuran derivative (1) was isolated from the roots of Petasites hybridus and its structure was determined as 1-(6-hydroxy-2-isopropenyl-1-benzofuran-5-yl)-1-ethanone by spectroscopic data and X-ray crystallographic analysis. The compound 1 showed moderate inhibitory activity on human breast cancer MCF-7 cells proliferation in vitro with an IC50 value of 48 mu mol/L. The interaction of bovine serum albumin (BSA) and DNA with compound 1 were studied in an aqueous solution under physiological conditions by UV-vis spectroscopy. (C) 2011 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.

U2 - 10.1016/j.phytol.2011.04.009

DO - 10.1016/j.phytol.2011.04.009

M3 - Article

SN - 1874-3900

VL - 4

SP - 254

EP - 258

JO - Phytochemistry Letters

JF - Phytochemistry Letters

ER -

A new bioactive compound from the roots of Petasites hybridus

Abstract

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