TY - JOUR
T1 - A new approach to the diagnosis and treatment of atherosclerosis
T2 - the era of the liposome
AU - Kiaie, Nasim
AU - Gorabi, Armita Mahdavi
AU - Penson, Peter E.
AU - Watts, Gerald
AU - Johnston, Thomas P.
AU - Banach, Maciej
AU - Sahebkar, Amirhossein
PY - 2020/1
Y1 - 2020/1
N2 - The consequences of atherosclerotic cardiovascular disease (ASCVD) include myocardial infarction, ischemic stroke, and angina pectoris, which are major causes of mortality and morbidity worldwide. Despite current therapeutic strategies to reduce risk, patients still experience the consequences of ASCVD. Consequently, a current goal is to enhance visualization of early atherosclerotic lesions to improve residual ASCVD risk. The uses of liposomes, in the context of ASCVD, can include as contrast agents for imaging techniques, as well as for the delivery of antiatherosclerotic drugs, genes, and cells to established sites of plaque. Additionally, liposomes have a role as vaccine adjuvants against mediators of atherosclerosis. Here. we review the scientific and clinical evidence relating to the use of liposomes in the diagnosis and management of ASCVD.
AB - The consequences of atherosclerotic cardiovascular disease (ASCVD) include myocardial infarction, ischemic stroke, and angina pectoris, which are major causes of mortality and morbidity worldwide. Despite current therapeutic strategies to reduce risk, patients still experience the consequences of ASCVD. Consequently, a current goal is to enhance visualization of early atherosclerotic lesions to improve residual ASCVD risk. The uses of liposomes, in the context of ASCVD, can include as contrast agents for imaging techniques, as well as for the delivery of antiatherosclerotic drugs, genes, and cells to established sites of plaque. Additionally, liposomes have a role as vaccine adjuvants against mediators of atherosclerosis. Here. we review the scientific and clinical evidence relating to the use of liposomes in the diagnosis and management of ASCVD.
UR - http://www.scopus.com/inward/record.url?scp=85072400437&partnerID=8YFLogxK
U2 - 10.1016/j.drudis.2019.09.005
DO - 10.1016/j.drudis.2019.09.005
M3 - Review article
C2 - 31525463
AN - SCOPUS:85072400437
SN - 1359-6446
VL - 25
SP - 58
EP - 72
JO - Drug Discovery Today
JF - Drug Discovery Today
IS - 1
ER -