A neuropsychological profile of off-diet adults with phenylketonuria

J.J. Moyle, Allison Fox, M. Bynevelt, M. Arthur, J.R. Burnett

Research output: Contribution to journalArticlepeer-review

43 Citations (Scopus)


The metabolic disorder phenylketonuria (PKU) is treated early by a low-phenylalanine diet. While this prevents global cognitive impairment, some patients still experience cognitive and neurophysiological abnormalities. Neuropsychological testing of early treated, currently off-diet, PKU patients attending an adult PKU clinic showed a reduction in the Perceptual Organization Index (POI), Processing Speed Index ( PSI) from the Wechsler Adult Intelligence Scale Third Edition (WAIS-III), and Part A of the Trail Making Test for the PKU group relative to controls. Taken together, these results supported a profile of reduced information-processing speed.
Original languageEnglish
Pages (from-to)436-441
JournalJournal of Clinical and Experimental Neuropsychology
Issue number4
Publication statusPublished - 2007


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