TY - JOUR
T1 - A naturalistic study of pharmacological management of behavioural disturbance in psychosis
AU - Addis, Steve
AU - Sherwood, Diane
AU - Mace, Wendy
AU - Mancuso, Serafino G.
AU - Koloth, Radhakrishnan
AU - Castle, David J.
PY - 2012/3/28
Y1 - 2012/3/28
N2 - Objective: To explore, using a naturalistic design, the efficacy of typical and atypical antipsychotics in the management of behavioural disturbance in people with psychiatric disorders. Method: Prospective naturalistic study of 15,278 incidents of behavioural disturbance perpetrated by 1,059 patients, over a two year period. Results: Typical and atypical antipsychotics did not differ in terms of their efficacy, overall. In terms of specific agents, haloperidol and quetiapine tended to show equal efficacy, with olanzapine being somewhat less effective on two of three outcome measures. Conclusions: Overall, atypical antipsychotics were as effective as typical agents in the management of acute behavioural disturbance in a mental health setting. Further work is required to determine the relative side effect burden of those agents.
AB - Objective: To explore, using a naturalistic design, the efficacy of typical and atypical antipsychotics in the management of behavioural disturbance in people with psychiatric disorders. Method: Prospective naturalistic study of 15,278 incidents of behavioural disturbance perpetrated by 1,059 patients, over a two year period. Results: Typical and atypical antipsychotics did not differ in terms of their efficacy, overall. In terms of specific agents, haloperidol and quetiapine tended to show equal efficacy, with olanzapine being somewhat less effective on two of three outcome measures. Conclusions: Overall, atypical antipsychotics were as effective as typical agents in the management of acute behavioural disturbance in a mental health setting. Further work is required to determine the relative side effect burden of those agents.
KW - anti-psychotics
KW - Behavioural disturbance
KW - schizophrenia
UR - http://www.scopus.com/inward/record.url?scp=85011476622&partnerID=8YFLogxK
U2 - 10.1017/S1742646412000076
DO - 10.1017/S1742646412000076
M3 - Article
AN - SCOPUS:85011476622
SN - 1742-6464
VL - 8
SP - 120
EP - 125
JO - Journal of Psychiatric Intensive Care
JF - Journal of Psychiatric Intensive Care
IS - 2
ER -