A narrative review of proteinuria and albuminuria as clinical biomarkers in children

Nicholas G Larkins, Armando Teixeira-Pinto, Jonathan C Craig

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

Proteinuria is an important biomarker commonly used to detect and manage kidney disease in children. There are now a variety of methods available to measure urinary protein loss, and physicians are faced with several contrasting strategies: 24-h or timed collection versus spot samples (first-morning or random), measurement of total urinary protein versus selective measurement of urinary albumin, unadjusted urine protein concentration versus protein-to-creatinine ratio and the use of dipstick versus laboratory-based methods. In this review, we will discuss the advantages and disadvantages of these different approaches. We will then summarise the evidence base for proteinuria as a clinical biomarker in different settings, including discussion of the current and potential role of measuring low-level albuminuria. Finally, we will highlight gaps in the literature and opportunities for further research into proteinuria among children.

Original languageEnglish
Pages (from-to)136-142
Number of pages7
JournalJournal of Paediatrics and Child Health
Volume55
Issue number2
DOIs
Publication statusPublished - Feb 2019
Externally publishedYes

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Albuminuria
Proteinuria
Biomarkers
Proteins
Kidney Diseases
Albumins
Creatinine
Urine
Physicians
Research

Bibliographical note

© 2018 Paediatrics and Child Health Division (The Royal Australasian College of Physicians).

Cite this

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A narrative review of proteinuria and albuminuria as clinical biomarkers in children. / Larkins, Nicholas G; Teixeira-Pinto, Armando; Craig, Jonathan C.

In: Journal of Paediatrics and Child Health, Vol. 55, No. 2, 02.2019, p. 136-142.

Research output: Contribution to journalReview article

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T1 - A narrative review of proteinuria and albuminuria as clinical biomarkers in children

AU - Larkins, Nicholas G

AU - Teixeira-Pinto, Armando

AU - Craig, Jonathan C

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AB - Proteinuria is an important biomarker commonly used to detect and manage kidney disease in children. There are now a variety of methods available to measure urinary protein loss, and physicians are faced with several contrasting strategies: 24-h or timed collection versus spot samples (first-morning or random), measurement of total urinary protein versus selective measurement of urinary albumin, unadjusted urine protein concentration versus protein-to-creatinine ratio and the use of dipstick versus laboratory-based methods. In this review, we will discuss the advantages and disadvantages of these different approaches. We will then summarise the evidence base for proteinuria as a clinical biomarker in different settings, including discussion of the current and potential role of measuring low-level albuminuria. Finally, we will highlight gaps in the literature and opportunities for further research into proteinuria among children.

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