A multicentre comparison of quantitative 90Y PET/CT for dosimetric purposes after radioembolization with resin microspheres: the QUEST Phantom Study

K.P. Willowson, M. Tapner, H. Ahmadzadehfar, H. Amthauer, O.S. Großer, J. Arbizu, J.M. Martí-Climent, M. Rodriguez-Fraile, A.A. Attarwala, G. Glatting, F. Molina-Duran, O. Bagni, L. Filippi, F. Benard, A. Celler, F. Bonutti, F. Botta, M. Ferrari, J.A. Boucek, Roslyn Francis & 68 others A.C. Bourgeois, Y.C. Bradley, A.S. Pasciak, H.G. Buchholz, M. Miederer, K.A. Büsing, S.O. Schönberg, T. Carlier, T. Eugene, M. Cervo, S.C. Moore, S. Civollani, C. Pettinato, M. Conti, A.J. Craig, G.D. Flux, M. Cremonesi, M. D’andrea, G. Iaccarino, L. Strigari, M. D’arienzo, Y. D’asseler, B. Lambert, F. Di Martino, M. Doss, H. Duan, M. Hoffmann, P. Flamen, B. Vanderlinden, A.M. Fletcher, E. Fourkal, L.M. Freeman, O. Geatti, A. Goedicke, C.M.R. Habito, J. Ouyang, A. Hallam, D.G. Morgan, S. Heard, F. Leek, S. Holm, J. Mortensen, R. De Nijs, C.A. Hooker, S.P. Jeans, P.J. Julyan, L. Kabasakal, H. Tanyildizi, S.C. Kappadath, W. Siman, M. Lassmann, S. Schlögl, M.W. Law, V.H. Lee, S.C. Ng, R. Lhommel, M.A. Lodge, M. Luster, D.R. Mcgowan, B. Mclamb, H.J. Kaiser, F.M. Mottaghy, R.U. Mulder, P. Judy, J.R. Stone, A. Lopez, O.L. Munk, D.L. Bailey

    Research output: Contribution to journalArticle

    67 Citations (Scopus)

    Abstract

    © 2015, The Author(s). Purpose: To investigate and compare the quantitative accuracy of 90Y imaging across different generation PET/CT scanners, for the purpose of dosimetry after radioembolization with resin microspheres. Methods: A strict experimental and imaging protocol was followed by 47 international sites using the NEMA 2007/IEC 2008 PET body phantom with an 8-to-1 sphere-to-background ratio of 90Y solution. The phantom was imaged over a 7-day period (activity ranging from 0.5 to 3.0 GBq) and all reconstructed data were analysed at a core laboratory for consistent processing. Quantitative accuracy was assessed through measures of total phantom activity, activity concentration in background and hot spheres, misplaced counts in a nonradioactive insert, and background variability. Results: Of the 69 scanners assessed, 37 had both time-of-flight (ToF) and resolution recovery (RR) capability. These current generation scanners from GE, Philips and Siemens could reconstruct background concentration measures to within 10 % of true values over the evaluated range, with greater deviations on the Philips systems at low count rates, and demonstrated typical partial volume effects on hot sphere recovery, which dominated spheres of diameter 20 mm in diameter, activity concentrations were consistently underestimated by about 20 %. Non-ToF scanners from GE Healthcare and Siemens were capable of producing accurate measures, but with inferior quantitative recovery compared with ToF systems. Conclusion: Current generation ToF scanners can consistently reconstruct 90Y activity concentrations, but they underestimate activity concentrations in small structures (≤37 mm diameter) within a warm background due to partial volume effects and constraints of the reconstruction algorithm. At the highest count rates investigated, measures of background concentration (about 300 kBq/ml) could be estimated on average to within 1 %, 5 % and 2 % for GE Healthcare (all-pass filter, RR + ToF), Philips (4i8s ToF) and Siemens (2i21s all-pass filter, RR + ToF) ToF systems, respectively. Over the range of activities investigated, comparable performance between GE Healthcare and Siemens ToF systems suggests suitability for quantitative analysis in a scenario analogous to that of postradioembolization imaging for treatment of liver cancer.
    Original languageEnglish
    Pages (from-to)1202-1222
    JournalEuropean Journal of Nuclear Medicine and Molecular Imaging
    Volume42
    Issue number8
    DOIs
    Publication statusPublished - 2015

    Fingerprint

    Microspheres
    Delivery of Health Care
    Liver Neoplasms

    Cite this

    Willowson, K.P. ; Tapner, M. ; Ahmadzadehfar, H. ; Amthauer, H. ; Großer, O.S. ; Arbizu, J. ; Martí-Climent, J.M. ; Rodriguez-Fraile, M. ; Attarwala, A.A. ; Glatting, G. ; Molina-Duran, F. ; Bagni, O. ; Filippi, L. ; Benard, F. ; Celler, A. ; Bonutti, F. ; Botta, F. ; Ferrari, M. ; Boucek, J.A. ; Francis, Roslyn ; Bourgeois, A.C. ; Bradley, Y.C. ; Pasciak, A.S. ; Buchholz, H.G. ; Miederer, M. ; Büsing, K.A. ; Schönberg, S.O. ; Carlier, T. ; Eugene, T. ; Cervo, M. ; Moore, S.C. ; Civollani, S. ; Pettinato, C. ; Conti, M. ; Craig, A.J. ; Flux, G.D. ; Cremonesi, M. ; D’andrea, M. ; Iaccarino, G. ; Strigari, L. ; D’arienzo, M. ; D’asseler, Y. ; Lambert, B. ; Di Martino, F. ; Doss, M. ; Duan, H. ; Hoffmann, M. ; Flamen, P. ; Vanderlinden, B. ; Fletcher, A.M. ; Fourkal, E. ; Freeman, L.M. ; Geatti, O. ; Goedicke, A. ; Habito, C.M.R. ; Ouyang, J. ; Hallam, A. ; Morgan, D.G. ; Heard, S. ; Leek, F. ; Holm, S. ; Mortensen, J. ; De Nijs, R. ; Hooker, C.A. ; Jeans, S.P. ; Julyan, P.J. ; Kabasakal, L. ; Tanyildizi, H. ; Kappadath, S.C. ; Siman, W. ; Lassmann, M. ; Schlögl, S. ; Law, M.W. ; Lee, V.H. ; Ng, S.C. ; Lhommel, R. ; Lodge, M.A. ; Luster, M. ; Mcgowan, D.R. ; Mclamb, B. ; Kaiser, H.J. ; Mottaghy, F.M. ; Mulder, R.U. ; Judy, P. ; Stone, J.R. ; Lopez, A. ; Munk, O.L. ; Bailey, D.L. / A multicentre comparison of quantitative 90Y PET/CT for dosimetric purposes after radioembolization with resin microspheres: the QUEST Phantom Study. In: European Journal of Nuclear Medicine and Molecular Imaging. 2015 ; Vol. 42, No. 8. pp. 1202-1222.
    @article{c53463e5fd204e10879c04b9bb4254f9,
    title = "A multicentre comparison of quantitative 90Y PET/CT for dosimetric purposes after radioembolization with resin microspheres: the QUEST Phantom Study",
    abstract = "{\circledC} 2015, The Author(s). Purpose: To investigate and compare the quantitative accuracy of 90Y imaging across different generation PET/CT scanners, for the purpose of dosimetry after radioembolization with resin microspheres. Methods: A strict experimental and imaging protocol was followed by 47 international sites using the NEMA 2007/IEC 2008 PET body phantom with an 8-to-1 sphere-to-background ratio of 90Y solution. The phantom was imaged over a 7-day period (activity ranging from 0.5 to 3.0 GBq) and all reconstructed data were analysed at a core laboratory for consistent processing. Quantitative accuracy was assessed through measures of total phantom activity, activity concentration in background and hot spheres, misplaced counts in a nonradioactive insert, and background variability. Results: Of the 69 scanners assessed, 37 had both time-of-flight (ToF) and resolution recovery (RR) capability. These current generation scanners from GE, Philips and Siemens could reconstruct background concentration measures to within 10 {\%} of true values over the evaluated range, with greater deviations on the Philips systems at low count rates, and demonstrated typical partial volume effects on hot sphere recovery, which dominated spheres of diameter 20 mm in diameter, activity concentrations were consistently underestimated by about 20 {\%}. Non-ToF scanners from GE Healthcare and Siemens were capable of producing accurate measures, but with inferior quantitative recovery compared with ToF systems. Conclusion: Current generation ToF scanners can consistently reconstruct 90Y activity concentrations, but they underestimate activity concentrations in small structures (≤37 mm diameter) within a warm background due to partial volume effects and constraints of the reconstruction algorithm. At the highest count rates investigated, measures of background concentration (about 300 kBq/ml) could be estimated on average to within 1 {\%}, 5 {\%} and 2 {\%} for GE Healthcare (all-pass filter, RR + ToF), Philips (4i8s ToF) and Siemens (2i21s all-pass filter, RR + ToF) ToF systems, respectively. Over the range of activities investigated, comparable performance between GE Healthcare and Siemens ToF systems suggests suitability for quantitative analysis in a scenario analogous to that of postradioembolization imaging for treatment of liver cancer.",
    author = "K.P. Willowson and M. Tapner and H. Ahmadzadehfar and H. Amthauer and O.S. Gro{\ss}er and J. Arbizu and J.M. Mart{\'i}-Climent and M. Rodriguez-Fraile and A.A. Attarwala and G. Glatting and F. Molina-Duran and O. Bagni and L. Filippi and F. Benard and A. Celler and F. Bonutti and F. Botta and M. Ferrari and J.A. Boucek and Roslyn Francis and A.C. Bourgeois and Y.C. Bradley and A.S. Pasciak and H.G. Buchholz and M. Miederer and K.A. B{\"u}sing and S.O. Sch{\"o}nberg and T. Carlier and T. Eugene and M. Cervo and S.C. Moore and S. Civollani and C. Pettinato and M. Conti and A.J. Craig and G.D. Flux and M. Cremonesi and M. D’andrea and G. Iaccarino and L. Strigari and M. D’arienzo and Y. D’asseler and B. Lambert and {Di Martino}, F. and M. Doss and H. Duan and M. Hoffmann and P. Flamen and B. Vanderlinden and A.M. Fletcher and E. Fourkal and L.M. Freeman and O. Geatti and A. Goedicke and C.M.R. Habito and J. Ouyang and A. Hallam and D.G. Morgan and S. Heard and F. Leek and S. Holm and J. Mortensen and {De Nijs}, R. and C.A. Hooker and S.P. Jeans and P.J. Julyan and L. Kabasakal and H. Tanyildizi and S.C. Kappadath and W. Siman and M. Lassmann and S. Schl{\"o}gl and M.W. Law and V.H. Lee and S.C. Ng and R. Lhommel and M.A. Lodge and M. Luster and D.R. Mcgowan and B. Mclamb and H.J. Kaiser and F.M. Mottaghy and R.U. Mulder and P. Judy and J.R. Stone and A. Lopez and O.L. Munk and D.L. Bailey",
    year = "2015",
    doi = "10.1007/s00259-015-3059-9",
    language = "English",
    volume = "42",
    pages = "1202--1222",
    journal = "European Journal of Nuclear Medicine",
    issn = "0340-6997",
    publisher = "Springer-Verlag London Ltd.",
    number = "8",

    }

    Willowson, KP, Tapner, M, Ahmadzadehfar, H, Amthauer, H, Großer, OS, Arbizu, J, Martí-Climent, JM, Rodriguez-Fraile, M, Attarwala, AA, Glatting, G, Molina-Duran, F, Bagni, O, Filippi, L, Benard, F, Celler, A, Bonutti, F, Botta, F, Ferrari, M, Boucek, JA, Francis, R, Bourgeois, AC, Bradley, YC, Pasciak, AS, Buchholz, HG, Miederer, M, Büsing, KA, Schönberg, SO, Carlier, T, Eugene, T, Cervo, M, Moore, SC, Civollani, S, Pettinato, C, Conti, M, Craig, AJ, Flux, GD, Cremonesi, M, D’andrea, M, Iaccarino, G, Strigari, L, D’arienzo, M, D’asseler, Y, Lambert, B, Di Martino, F, Doss, M, Duan, H, Hoffmann, M, Flamen, P, Vanderlinden, B, Fletcher, AM, Fourkal, E, Freeman, LM, Geatti, O, Goedicke, A, Habito, CMR, Ouyang, J, Hallam, A, Morgan, DG, Heard, S, Leek, F, Holm, S, Mortensen, J, De Nijs, R, Hooker, CA, Jeans, SP, Julyan, PJ, Kabasakal, L, Tanyildizi, H, Kappadath, SC, Siman, W, Lassmann, M, Schlögl, S, Law, MW, Lee, VH, Ng, SC, Lhommel, R, Lodge, MA, Luster, M, Mcgowan, DR, Mclamb, B, Kaiser, HJ, Mottaghy, FM, Mulder, RU, Judy, P, Stone, JR, Lopez, A, Munk, OL & Bailey, DL 2015, 'A multicentre comparison of quantitative 90Y PET/CT for dosimetric purposes after radioembolization with resin microspheres: the QUEST Phantom Study' European Journal of Nuclear Medicine and Molecular Imaging, vol. 42, no. 8, pp. 1202-1222. https://doi.org/10.1007/s00259-015-3059-9

    A multicentre comparison of quantitative 90Y PET/CT for dosimetric purposes after radioembolization with resin microspheres: the QUEST Phantom Study. / Willowson, K.P.; Tapner, M.; Ahmadzadehfar, H.; Amthauer, H.; Großer, O.S.; Arbizu, J.; Martí-Climent, J.M.; Rodriguez-Fraile, M.; Attarwala, A.A.; Glatting, G.; Molina-Duran, F.; Bagni, O.; Filippi, L.; Benard, F.; Celler, A.; Bonutti, F.; Botta, F.; Ferrari, M.; Boucek, J.A.; Francis, Roslyn; Bourgeois, A.C.; Bradley, Y.C.; Pasciak, A.S.; Buchholz, H.G.; Miederer, M.; Büsing, K.A.; Schönberg, S.O.; Carlier, T.; Eugene, T.; Cervo, M.; Moore, S.C.; Civollani, S.; Pettinato, C.; Conti, M.; Craig, A.J.; Flux, G.D.; Cremonesi, M.; D’andrea, M.; Iaccarino, G.; Strigari, L.; D’arienzo, M.; D’asseler, Y.; Lambert, B.; Di Martino, F.; Doss, M.; Duan, H.; Hoffmann, M.; Flamen, P.; Vanderlinden, B.; Fletcher, A.M.; Fourkal, E.; Freeman, L.M.; Geatti, O.; Goedicke, A.; Habito, C.M.R.; Ouyang, J.; Hallam, A.; Morgan, D.G.; Heard, S.; Leek, F.; Holm, S.; Mortensen, J.; De Nijs, R.; Hooker, C.A.; Jeans, S.P.; Julyan, P.J.; Kabasakal, L.; Tanyildizi, H.; Kappadath, S.C.; Siman, W.; Lassmann, M.; Schlögl, S.; Law, M.W.; Lee, V.H.; Ng, S.C.; Lhommel, R.; Lodge, M.A.; Luster, M.; Mcgowan, D.R.; Mclamb, B.; Kaiser, H.J.; Mottaghy, F.M.; Mulder, R.U.; Judy, P.; Stone, J.R.; Lopez, A.; Munk, O.L.; Bailey, D.L.

    In: European Journal of Nuclear Medicine and Molecular Imaging, Vol. 42, No. 8, 2015, p. 1202-1222.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - A multicentre comparison of quantitative 90Y PET/CT for dosimetric purposes after radioembolization with resin microspheres: the QUEST Phantom Study

    AU - Willowson, K.P.

    AU - Tapner, M.

    AU - Ahmadzadehfar, H.

    AU - Amthauer, H.

    AU - Großer, O.S.

    AU - Arbizu, J.

    AU - Martí-Climent, J.M.

    AU - Rodriguez-Fraile, M.

    AU - Attarwala, A.A.

    AU - Glatting, G.

    AU - Molina-Duran, F.

    AU - Bagni, O.

    AU - Filippi, L.

    AU - Benard, F.

    AU - Celler, A.

    AU - Bonutti, F.

    AU - Botta, F.

    AU - Ferrari, M.

    AU - Boucek, J.A.

    AU - Francis, Roslyn

    AU - Bourgeois, A.C.

    AU - Bradley, Y.C.

    AU - Pasciak, A.S.

    AU - Buchholz, H.G.

    AU - Miederer, M.

    AU - Büsing, K.A.

    AU - Schönberg, S.O.

    AU - Carlier, T.

    AU - Eugene, T.

    AU - Cervo, M.

    AU - Moore, S.C.

    AU - Civollani, S.

    AU - Pettinato, C.

    AU - Conti, M.

    AU - Craig, A.J.

    AU - Flux, G.D.

    AU - Cremonesi, M.

    AU - D’andrea, M.

    AU - Iaccarino, G.

    AU - Strigari, L.

    AU - D’arienzo, M.

    AU - D’asseler, Y.

    AU - Lambert, B.

    AU - Di Martino, F.

    AU - Doss, M.

    AU - Duan, H.

    AU - Hoffmann, M.

    AU - Flamen, P.

    AU - Vanderlinden, B.

    AU - Fletcher, A.M.

    AU - Fourkal, E.

    AU - Freeman, L.M.

    AU - Geatti, O.

    AU - Goedicke, A.

    AU - Habito, C.M.R.

    AU - Ouyang, J.

    AU - Hallam, A.

    AU - Morgan, D.G.

    AU - Heard, S.

    AU - Leek, F.

    AU - Holm, S.

    AU - Mortensen, J.

    AU - De Nijs, R.

    AU - Hooker, C.A.

    AU - Jeans, S.P.

    AU - Julyan, P.J.

    AU - Kabasakal, L.

    AU - Tanyildizi, H.

    AU - Kappadath, S.C.

    AU - Siman, W.

    AU - Lassmann, M.

    AU - Schlögl, S.

    AU - Law, M.W.

    AU - Lee, V.H.

    AU - Ng, S.C.

    AU - Lhommel, R.

    AU - Lodge, M.A.

    AU - Luster, M.

    AU - Mcgowan, D.R.

    AU - Mclamb, B.

    AU - Kaiser, H.J.

    AU - Mottaghy, F.M.

    AU - Mulder, R.U.

    AU - Judy, P.

    AU - Stone, J.R.

    AU - Lopez, A.

    AU - Munk, O.L.

    AU - Bailey, D.L.

    PY - 2015

    Y1 - 2015

    N2 - © 2015, The Author(s). Purpose: To investigate and compare the quantitative accuracy of 90Y imaging across different generation PET/CT scanners, for the purpose of dosimetry after radioembolization with resin microspheres. Methods: A strict experimental and imaging protocol was followed by 47 international sites using the NEMA 2007/IEC 2008 PET body phantom with an 8-to-1 sphere-to-background ratio of 90Y solution. The phantom was imaged over a 7-day period (activity ranging from 0.5 to 3.0 GBq) and all reconstructed data were analysed at a core laboratory for consistent processing. Quantitative accuracy was assessed through measures of total phantom activity, activity concentration in background and hot spheres, misplaced counts in a nonradioactive insert, and background variability. Results: Of the 69 scanners assessed, 37 had both time-of-flight (ToF) and resolution recovery (RR) capability. These current generation scanners from GE, Philips and Siemens could reconstruct background concentration measures to within 10 % of true values over the evaluated range, with greater deviations on the Philips systems at low count rates, and demonstrated typical partial volume effects on hot sphere recovery, which dominated spheres of diameter 20 mm in diameter, activity concentrations were consistently underestimated by about 20 %. Non-ToF scanners from GE Healthcare and Siemens were capable of producing accurate measures, but with inferior quantitative recovery compared with ToF systems. Conclusion: Current generation ToF scanners can consistently reconstruct 90Y activity concentrations, but they underestimate activity concentrations in small structures (≤37 mm diameter) within a warm background due to partial volume effects and constraints of the reconstruction algorithm. At the highest count rates investigated, measures of background concentration (about 300 kBq/ml) could be estimated on average to within 1 %, 5 % and 2 % for GE Healthcare (all-pass filter, RR + ToF), Philips (4i8s ToF) and Siemens (2i21s all-pass filter, RR + ToF) ToF systems, respectively. Over the range of activities investigated, comparable performance between GE Healthcare and Siemens ToF systems suggests suitability for quantitative analysis in a scenario analogous to that of postradioembolization imaging for treatment of liver cancer.

    AB - © 2015, The Author(s). Purpose: To investigate and compare the quantitative accuracy of 90Y imaging across different generation PET/CT scanners, for the purpose of dosimetry after radioembolization with resin microspheres. Methods: A strict experimental and imaging protocol was followed by 47 international sites using the NEMA 2007/IEC 2008 PET body phantom with an 8-to-1 sphere-to-background ratio of 90Y solution. The phantom was imaged over a 7-day period (activity ranging from 0.5 to 3.0 GBq) and all reconstructed data were analysed at a core laboratory for consistent processing. Quantitative accuracy was assessed through measures of total phantom activity, activity concentration in background and hot spheres, misplaced counts in a nonradioactive insert, and background variability. Results: Of the 69 scanners assessed, 37 had both time-of-flight (ToF) and resolution recovery (RR) capability. These current generation scanners from GE, Philips and Siemens could reconstruct background concentration measures to within 10 % of true values over the evaluated range, with greater deviations on the Philips systems at low count rates, and demonstrated typical partial volume effects on hot sphere recovery, which dominated spheres of diameter 20 mm in diameter, activity concentrations were consistently underestimated by about 20 %. Non-ToF scanners from GE Healthcare and Siemens were capable of producing accurate measures, but with inferior quantitative recovery compared with ToF systems. Conclusion: Current generation ToF scanners can consistently reconstruct 90Y activity concentrations, but they underestimate activity concentrations in small structures (≤37 mm diameter) within a warm background due to partial volume effects and constraints of the reconstruction algorithm. At the highest count rates investigated, measures of background concentration (about 300 kBq/ml) could be estimated on average to within 1 %, 5 % and 2 % for GE Healthcare (all-pass filter, RR + ToF), Philips (4i8s ToF) and Siemens (2i21s all-pass filter, RR + ToF) ToF systems, respectively. Over the range of activities investigated, comparable performance between GE Healthcare and Siemens ToF systems suggests suitability for quantitative analysis in a scenario analogous to that of postradioembolization imaging for treatment of liver cancer.

    U2 - 10.1007/s00259-015-3059-9

    DO - 10.1007/s00259-015-3059-9

    M3 - Article

    VL - 42

    SP - 1202

    EP - 1222

    JO - European Journal of Nuclear Medicine

    JF - European Journal of Nuclear Medicine

    SN - 0340-6997

    IS - 8

    ER -