A multi-step peptidolytic cascade for amino acid recovery in chloroplasts

Pedro F. Teixeira, Beata Kmiec, Rui M M Branca, Monika W. Murcha, Anna Byzia, Aneta Ivanova, James Whelan, Marcin Drag, Janne Lehtiö, Elzbieta Glaser

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Plastids (including chloroplasts) are subcellular sites for a plethora of proteolytic reactions, required in functions ranging from protein biogenesis to quality control. Here we show that peptides generated from pre-protein maturation within chloroplasts of Arabidopsis thaliana are degraded to amino acids by a multi-step peptidolytic cascade consisting of oligopeptidases and aminopeptidases, effectively allowing the recovery of single amino acids within these organelles.

Original languageEnglish
Pages (from-to)15-17
Number of pages3
JournalNature Chemical Biology
Volume13
Issue number1
DOIs
Publication statusPublished - 1 Jan 2017

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Chloroplasts
Amino Acids
Aminopeptidases
Plastids
Arabidopsis
Quality Control
Organelles
Proteins
Peptides
oligopeptidase

Cite this

Teixeira, Pedro F. ; Kmiec, Beata ; Branca, Rui M M ; Murcha, Monika W. ; Byzia, Anna ; Ivanova, Aneta ; Whelan, James ; Drag, Marcin ; Lehtiö, Janne ; Glaser, Elzbieta. / A multi-step peptidolytic cascade for amino acid recovery in chloroplasts. In: Nature Chemical Biology. 2017 ; Vol. 13, No. 1. pp. 15-17.
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Teixeira, PF, Kmiec, B, Branca, RMM, Murcha, MW, Byzia, A, Ivanova, A, Whelan, J, Drag, M, Lehtiö, J & Glaser, E 2017, 'A multi-step peptidolytic cascade for amino acid recovery in chloroplasts' Nature Chemical Biology, vol. 13, no. 1, pp. 15-17. https://doi.org/10.1038/nchembio.2227

A multi-step peptidolytic cascade for amino acid recovery in chloroplasts. / Teixeira, Pedro F.; Kmiec, Beata; Branca, Rui M M; Murcha, Monika W.; Byzia, Anna; Ivanova, Aneta; Whelan, James; Drag, Marcin; Lehtiö, Janne; Glaser, Elzbieta.

In: Nature Chemical Biology, Vol. 13, No. 1, 01.01.2017, p. 15-17.

Research output: Contribution to journalArticle

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