A multi-step peptidolytic cascade for amino acid recovery in chloroplasts

Pedro F. Teixeira, Beata Kmiec, Rui M M Branca, Monika W. Murcha, Anna Byzia, Aneta Ivanova, James Whelan, Marcin Drag, Janne Lehtiö, Elzbieta Glaser

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)


Plastids (including chloroplasts) are subcellular sites for a plethora of proteolytic reactions, required in functions ranging from protein biogenesis to quality control. Here we show that peptides generated from pre-protein maturation within chloroplasts of Arabidopsis thaliana are degraded to amino acids by a multi-step peptidolytic cascade consisting of oligopeptidases and aminopeptidases, effectively allowing the recovery of single amino acids within these organelles.

Original languageEnglish
Pages (from-to)15-17
Number of pages3
JournalNature Chemical Biology
Issue number1
Publication statusPublished - 1 Jan 2017


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