[Truncated] There has been much research into the process of angiogenesis (ie. growth of new blood vessels from the existing vasculature) in relation to physiologic wound repair and various pathoses. Results of these studies have led to conflicting views as to the role of various vascular cells (endothelial cells and pericytes) and the exact sequence of cellular events involved in angiogenesis. In addition, there has been a variety of in vitro and in vivo models used to investigate angiogenesis and results from these studies have also led to conflicting conclusions. This research study used an in vivo model to examine angiogenesis in the physiologic setting of the developing corpus luteum (CL) within pregnant rat ovaries. Its aim was to describe definitively the sequential steps and the role of the vascular cells involved in angiogenesis.
|Doctor of Philosophy
|Unpublished - 2002
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