A microfluidic platform to synthesise a G-quadruplex binding ligand

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17 Citations (Scopus)


An aromatic triarylpyridine chromophore promotes π-stacking interactions with the terminal G-tetrad in quadruplex DNA, stabilizing the structure and presenting a pathway towards cancer treatment by inhibition of telomerase. An interesting parent compound in this class is the dimethylamino functionalised 4′-aryl-2,6-bis(4-aminophenyl)pyridine. However, access to this compound using traditional batch synthetic methodology is limited, due to thermodynamic and kinetic constraints. A novel approach to the synthesis of this compound has been developed, involving dynamic thin films, overcoming a series of competing reactions, effectively controlling chemical reactivity and selectivity.
Original languageEnglish
Pages (from-to)2021-2025
JournalLab on a Chip
Publication statusPublished - 2009


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