A mechanism-based GlcNAc-inspired cyclophellitol inactivator of the peptidoglycan recycling enzyme NagZ reverses resistance to β-lactams in Pseudomonas aeruginosa

Louisa A. Ho, Judith L. Winogrodzki, Aleksandra W. Debowski, Zarina Madden, David J. Vocadlo, Brian L. Mark, Keith A. Stubbs

Research output: Contribution to journalArticle

5 Citations (Scopus)
343 Downloads (Pure)

Abstract

The development of a potent mechanism-based inactivator of NagZ, an enzyme critical to the production of inducible AmpC β-lactamase in Gram-negative bacteria, is presented. This inactivator significantly reduces MIC values for important β-lactams against a clinically relevant strain of Pseudomonas aeruginosa.

Original languageEnglish
Pages (from-to)10630-10633
Number of pages4
JournalChemical Communications
Volume54
Issue number75
DOIs
Publication statusPublished - 1 Jan 2018

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