A mechanism-based GlcNAc-inspired cyclophellitol inactivator of the peptidoglycan recycling enzyme NagZ reverses resistance to β-lactams in Pseudomonas aeruginosa

Louisa A. Ho; Judith L. Winogrodzki; Aleksandra W. Debowski; Zarina Madden; David J. Vocadlo; Brian L. Mark; Keith A. Stubbs

doi:10.1039/c8cc05281f

A mechanism-based GlcNAc-inspired cyclophellitol inactivator of the peptidoglycan recycling enzyme NagZ reverses resistance to β-lactams in Pseudomonas aeruginosa

Louisa A. Ho, Judith L. Winogrodzki, Aleksandra W. Debowski, Zarina Madden, David J. Vocadlo, Brian L. Mark, Keith A. Stubbs

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

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Abstract

The development of a potent mechanism-based inactivator of NagZ, an enzyme critical to the production of inducible AmpC β-lactamase in Gram-negative bacteria, is presented. This inactivator significantly reduces MIC values for important β-lactams against a clinically relevant strain of Pseudomonas aeruginosa.

Original language	English
Pages (from-to)	10630-10633
Number of pages	4
Journal	Chemical Communications
Volume	54
Issue number	75
DOIs	https://doi.org/10.1039/c8cc05281f
Publication status	Published - 1 Jan 2018

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10.1039/c8cc05281f

AAM_ a mechansm-based

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title = "A mechanism-based GlcNAc-inspired cyclophellitol inactivator of the peptidoglycan recycling enzyme NagZ reverses resistance to β-lactams in Pseudomonas aeruginosa",

abstract = "The development of a potent mechanism-based inactivator of NagZ, an enzyme critical to the production of inducible AmpC β-lactamase in Gram-negative bacteria, is presented. This inactivator significantly reduces MIC values for important β-lactams against a clinically relevant strain of Pseudomonas aeruginosa.",

author = "Ho, {Louisa A.} and Winogrodzki, {Judith L.} and Debowski, {Aleksandra W.} and Zarina Madden and Vocadlo, {David J.} and Mark, {Brian L.} and Stubbs, {Keith A.}",

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A mechanism-based GlcNAc-inspired cyclophellitol inactivator of the peptidoglycan recycling enzyme NagZ reverses resistance to β-lactams in Pseudomonas aeruginosa. / Ho, Louisa A.; Winogrodzki, Judith L.; Debowski, Aleksandra W. et al.
In: Chemical Communications, Vol. 54, No. 75, 01.01.2018, p. 10630-10633.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - A mechanism-based GlcNAc-inspired cyclophellitol inactivator of the peptidoglycan recycling enzyme NagZ reverses resistance to β-lactams in Pseudomonas aeruginosa

AU - Ho, Louisa A.

AU - Winogrodzki, Judith L.

AU - Debowski, Aleksandra W.

AU - Madden, Zarina

AU - Vocadlo, David J.

AU - Mark, Brian L.

AU - Stubbs, Keith A.

PY - 2018/1/1

Y1 - 2018/1/1

N2 - The development of a potent mechanism-based inactivator of NagZ, an enzyme critical to the production of inducible AmpC β-lactamase in Gram-negative bacteria, is presented. This inactivator significantly reduces MIC values for important β-lactams against a clinically relevant strain of Pseudomonas aeruginosa.

AB - The development of a potent mechanism-based inactivator of NagZ, an enzyme critical to the production of inducible AmpC β-lactamase in Gram-negative bacteria, is presented. This inactivator significantly reduces MIC values for important β-lactams against a clinically relevant strain of Pseudomonas aeruginosa.

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U2 - 10.1039/c8cc05281f

DO - 10.1039/c8cc05281f

M3 - Article

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AN - SCOPUS:85053493788

SN - 1359-7345

VL - 54

SP - 10630

EP - 10633

JO - Chemical Communications

JF - Chemical Communications

IS - 75

ER -

A mechanism-based GlcNAc-inspired cyclophellitol inactivator of the peptidoglycan recycling enzyme NagZ reverses resistance to β-lactams in Pseudomonas aeruginosa

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