A matter of (good) timing: Dynamic biomarker discovery in immune checkpoint blockade

Melvin Chin

Research output: ThesisDoctoral Thesis

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Abstract

Immune checkpoint blockade (ICB) has revolutionised cancer treatment, yet treatment response remains highly variable across patients and tumour types. Biomarker research, which hopes to improve ICB outcomes, has focused on pre-treatment biomarkers rather than dynamic biomarkers due to the clinical complexities of harvesting and analysing multi-timepoint patient data. Consequently, the existence and clinical translatability of dynamic biomarkers remains unexplored. The work in this thesis addresses the computational challenge of studying dynamic ICB biomarkers and provides proof-of-concept that these biomarkers can be exploited to enhance ICB response.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
Supervisors/Advisors
  • Lesterhuis, Joost, Supervisor, External person
  • Lassmann, Timo, Supervisor
  • Nowak, Anna, Supervisor
  • Lake, Richard, Supervisor
Thesis sponsors
Award date24 Feb 2023
DOIs
Publication statusUnpublished - 2022

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