TY - JOUR
T1 - A long term study of the interaction between iron and alcohol in an animal model of iron overload
AU - Olynyk, John
AU - Mackinnon, M.
AU - Reed, William
AU - Kerr, R.
AU - Hall, P.
AU - Williams, P.
PY - 1995
Y1 - 1995
N2 - Background/Aims: The hypothesis that chronic alcohol ingestion potentiates iron-associated liver injury was investigated in the 'carbonyl iron-overload rat model).Methods: Newborn male and female Wistar-Furth rats (seven per group) were used to investigate iron-alcohol interaction over a 26-week period, Groups 1 and 2 were iron loaded from birth, while the others received normal diet, At 10 weeks all rats commenced Lieber-DeCarli liquid diet; additional treatments were: group 1 6 g carbonyl iron/1000 mi diet plus alcohol; group 2 carbonyl iron in the liquid diet; group 3 alcohol in the liquid diet; group 4, the controls, received liquid diet only.Results: This study confirmed our previous observation that iron-loading from birth resulted in grade m-Iv siderosis, in both male and female rats, and caused fibrosis associated with periportal macrophages. Alcohol-feeding, in addition to iron-feeding for 26 weeks significantly lowered the hepatic iron concentration in both male and female rats compared to those fed iron only (p
AB - Background/Aims: The hypothesis that chronic alcohol ingestion potentiates iron-associated liver injury was investigated in the 'carbonyl iron-overload rat model).Methods: Newborn male and female Wistar-Furth rats (seven per group) were used to investigate iron-alcohol interaction over a 26-week period, Groups 1 and 2 were iron loaded from birth, while the others received normal diet, At 10 weeks all rats commenced Lieber-DeCarli liquid diet; additional treatments were: group 1 6 g carbonyl iron/1000 mi diet plus alcohol; group 2 carbonyl iron in the liquid diet; group 3 alcohol in the liquid diet; group 4, the controls, received liquid diet only.Results: This study confirmed our previous observation that iron-loading from birth resulted in grade m-Iv siderosis, in both male and female rats, and caused fibrosis associated with periportal macrophages. Alcohol-feeding, in addition to iron-feeding for 26 weeks significantly lowered the hepatic iron concentration in both male and female rats compared to those fed iron only (p
U2 - 10.1016/0168-8278(95)80222-3
DO - 10.1016/0168-8278(95)80222-3
M3 - Article
VL - 22
SP - 671
EP - 676
JO - Journal of Hepatology
JF - Journal of Hepatology
ER -