A long term study of the interaction between iron and alcohol in an animal model of iron overload

John Olynyk, M. Mackinnon, William Reed, R. Kerr, P. Hall, P. Williams

    Research output: Contribution to journalArticle

    46 Citations (Scopus)

    Abstract

    Background/Aims: The hypothesis that chronic alcohol ingestion potentiates iron-associated liver injury was investigated in the 'carbonyl iron-overload rat model).Methods: Newborn male and female Wistar-Furth rats (seven per group) were used to investigate iron-alcohol interaction over a 26-week period, Groups 1 and 2 were iron loaded from birth, while the others received normal diet, At 10 weeks all rats commenced Lieber-DeCarli liquid diet; additional treatments were: group 1 6 g carbonyl iron/1000 mi diet plus alcohol; group 2 carbonyl iron in the liquid diet; group 3 alcohol in the liquid diet; group 4, the controls, received liquid diet only.Results: This study confirmed our previous observation that iron-loading from birth resulted in grade m-Iv siderosis, in both male and female rats, and caused fibrosis associated with periportal macrophages. Alcohol-feeding, in addition to iron-feeding for 26 weeks significantly lowered the hepatic iron concentration in both male and female rats compared to those fed iron only (p
    Original languageEnglish
    Pages (from-to)671-676
    JournalJournal of Hepatology
    Volume22
    DOIs
    Publication statusPublished - 1995

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