A histological study on normal and abnormal airway development in an ovine model

Ie Lien Romero

Research output: ThesisMaster's Thesis

14 Downloads (Pure)

Abstract

Physiological abnormalities of the airway prior to the onset of asthma and from the earliest stages of life are consistent with the notion that asthma has developmental origins. This project utilised an ovine model to investigate the structural mechanism of airway smooth muscle (ASM) thickening associated with maturation and the susceptibility of these maturational processes to chronic intrauterine infection, analogous to chorioamnionitis which is a risk factor for asthma. Findings indicate that cellular hyperplasia is the predominant mechanism associated with normal ASM growth and that chronic intrauterine infection may cause localised thickening of the ASM layer in the peripheral airways.
Original languageEnglish
QualificationMasters
Awarding Institution
  • The University of Western Australia
Supervisors/Advisors
  • Noble, Peter, Supervisor
  • Wang, Kimberley, Supervisor
  • Elliot, John, Supervisor
Thesis sponsors
Award date1 Jul 2021
DOIs
Publication statusUnpublished - 2021

Fingerprint

Dive into the research topics of 'A histological study on normal and abnormal airway development in an ovine model'. Together they form a unique fingerprint.

Cite this