A guide to missing data for the pediatric nephrologist

Nicholas G. Larkins, Jonathan C. Craig, Armando Teixeira-Pinto

Research output: Contribution to journalReview articlepeer-review

4 Citations (Scopus)


Missing data is an important and common source of bias in clinical research. Readers should be alert to and consider the impact of missing data when reading studies. Beyond preventing missing data in the first place, through good study design and conduct, there are different strategies available to handle data containing missing observations. Complete case analysis is often biased unless data are missing completely at random. Better methods of handling missing data include multiple imputation and models using likelihood-based estimation. With advancing computing power and modern statistical software, these methods are within the reach of clinician-researchers under guidance of a biostatistician. As clinicians reading papers, we need to continue to update our understanding of statistical methods, so that we understand the limitations of these techniques and can critically interpret literature. © 2018 IPNA
Original languageEnglish
Pages (from-to)223-231
Number of pages9
JournalPediatric Nephrology
Issue number2
Publication statusE-pub ahead of print - 13 Mar 2018
Externally publishedYes


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