A Global Comparison of Anatomic Risk Factors and Their Relationship to Obstructive Sleep Apnea Severity in Clinical Samples

SAGIC Investigators

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Study Objectives: Obstructive sleep apnea (OSA) is a global health issue and is associated with obesity and oropharyngeal crowding. Global data are limited on the effect of ethnicity and sex on these relationships. We compare associations between the apnea-hypopnea index (AHI) and these risk factors across ethnicities and sexes within sleep clinics.

Methods: This is a cross-sectional, multicenter study of patients with OSA from eight sleep centers representing the Sleep Apnea Global Interdisciplinary Consortium (SAGIC). Four distinct ethnic groups were analyzed, using a structured questionnaire: Caucasians (Australia, Iceland, Germany, United States), African Americans (United States), Asians (Taiwan), and South Americans (Brazil). Regression analyses and interaction tests were used to assess ethnic and sex differences in relationships between AHI and anthropometric measures (body mass index [BMI], neck circumference, waist circumference) or Mallampati score.

Results: Analyses included 1,585 individuals from four ethnic groups: Caucasian (60.6%), African American (17.5%), Asian (13.1%), and South American (8.9%). BMI was most strongly associated with AHI in South Americans (7.8% increase in AHI per 1 kg/m(2) increase in BMI; P

Conclusions: We demonstrate ethnic and sex variations in associations between obesity and OSA. For similar BMI increases, South American patients show greatest AHI increases compared to African Americans. Findings highlight the importance of considering ethnicity and sex in clinical assessments of OSA risk.

Original languageEnglish
Article numberPII jc-18-00173
Pages (from-to)629-639
Number of pages11
JournalJournal of clinical sleep medicine
Volume15
Issue number4
DOIs
Publication statusPublished - 2019

Cite this

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title = "A Global Comparison of Anatomic Risk Factors and Their Relationship to Obstructive Sleep Apnea Severity in Clinical Samples",
abstract = "Study Objectives: Obstructive sleep apnea (OSA) is a global health issue and is associated with obesity and oropharyngeal crowding. Global data are limited on the effect of ethnicity and sex on these relationships. We compare associations between the apnea-hypopnea index (AHI) and these risk factors across ethnicities and sexes within sleep clinics.Methods: This is a cross-sectional, multicenter study of patients with OSA from eight sleep centers representing the Sleep Apnea Global Interdisciplinary Consortium (SAGIC). Four distinct ethnic groups were analyzed, using a structured questionnaire: Caucasians (Australia, Iceland, Germany, United States), African Americans (United States), Asians (Taiwan), and South Americans (Brazil). Regression analyses and interaction tests were used to assess ethnic and sex differences in relationships between AHI and anthropometric measures (body mass index [BMI], neck circumference, waist circumference) or Mallampati score.Results: Analyses included 1,585 individuals from four ethnic groups: Caucasian (60.6{\%}), African American (17.5{\%}), Asian (13.1{\%}), and South American (8.9{\%}). BMI was most strongly associated with AHI in South Americans (7.8{\%} increase in AHI per 1 kg/m(2) increase in BMI; PConclusions: We demonstrate ethnic and sex variations in associations between obesity and OSA. For similar BMI increases, South American patients show greatest AHI increases compared to African Americans. Findings highlight the importance of considering ethnicity and sex in clinical assessments of OSA risk.",
keywords = "anthropometry, ethnicity, Mallampati score, obesity, obstructive sleep apnea, UPPER AIRWAY, WAIST CIRCUMFERENCE, GENERAL-POPULATION, RESPIRATORY EVENTS, GENDER-DIFFERENCES, GENETIC ANCESTRY, FAT DISTRIBUTION, SEX-DIFFERENCES, ASSOCIATION, OBESITY",
author = "{SAGIC Investigators} and Kate Sutherland and Keenan, {Brendan T.} and Lia Bittencourt and Ning-hung Chen and Thorarinn Gislason and Sarah Leinwand and Magalang, {Ulysses J.} and Greg Maislin and Mazzotti, {Diego R.} and Nigel McArdle and Jesse Mindel and Pack, {Allan I.} and Thomas Penzel and Bhajan Singh and Sergio Tufik and Schwab, {Richard J.} and Cistulli, {Peter A.}",
year = "2019",
doi = "10.5664/jcsm.7730",
language = "English",
volume = "15",
pages = "629--639",
journal = "Journal of Clincal Sleep Medicine",
issn = "1550-9389",
publisher = "AMER ACAD SLEEP MEDICINE",
number = "4",

}

A Global Comparison of Anatomic Risk Factors and Their Relationship to Obstructive Sleep Apnea Severity in Clinical Samples. / SAGIC Investigators.

In: Journal of clinical sleep medicine, Vol. 15, No. 4, PII jc-18-00173, 2019, p. 629-639.

Research output: Contribution to journalArticle

TY - JOUR

T1 - A Global Comparison of Anatomic Risk Factors and Their Relationship to Obstructive Sleep Apnea Severity in Clinical Samples

AU - SAGIC Investigators

AU - Sutherland, Kate

AU - Keenan, Brendan T.

AU - Bittencourt, Lia

AU - Chen, Ning-hung

AU - Gislason, Thorarinn

AU - Leinwand, Sarah

AU - Magalang, Ulysses J.

AU - Maislin, Greg

AU - Mazzotti, Diego R.

AU - McArdle, Nigel

AU - Mindel, Jesse

AU - Pack, Allan I.

AU - Penzel, Thomas

AU - Singh, Bhajan

AU - Tufik, Sergio

AU - Schwab, Richard J.

AU - Cistulli, Peter A.

PY - 2019

Y1 - 2019

N2 - Study Objectives: Obstructive sleep apnea (OSA) is a global health issue and is associated with obesity and oropharyngeal crowding. Global data are limited on the effect of ethnicity and sex on these relationships. We compare associations between the apnea-hypopnea index (AHI) and these risk factors across ethnicities and sexes within sleep clinics.Methods: This is a cross-sectional, multicenter study of patients with OSA from eight sleep centers representing the Sleep Apnea Global Interdisciplinary Consortium (SAGIC). Four distinct ethnic groups were analyzed, using a structured questionnaire: Caucasians (Australia, Iceland, Germany, United States), African Americans (United States), Asians (Taiwan), and South Americans (Brazil). Regression analyses and interaction tests were used to assess ethnic and sex differences in relationships between AHI and anthropometric measures (body mass index [BMI], neck circumference, waist circumference) or Mallampati score.Results: Analyses included 1,585 individuals from four ethnic groups: Caucasian (60.6%), African American (17.5%), Asian (13.1%), and South American (8.9%). BMI was most strongly associated with AHI in South Americans (7.8% increase in AHI per 1 kg/m(2) increase in BMI; PConclusions: We demonstrate ethnic and sex variations in associations between obesity and OSA. For similar BMI increases, South American patients show greatest AHI increases compared to African Americans. Findings highlight the importance of considering ethnicity and sex in clinical assessments of OSA risk.

AB - Study Objectives: Obstructive sleep apnea (OSA) is a global health issue and is associated with obesity and oropharyngeal crowding. Global data are limited on the effect of ethnicity and sex on these relationships. We compare associations between the apnea-hypopnea index (AHI) and these risk factors across ethnicities and sexes within sleep clinics.Methods: This is a cross-sectional, multicenter study of patients with OSA from eight sleep centers representing the Sleep Apnea Global Interdisciplinary Consortium (SAGIC). Four distinct ethnic groups were analyzed, using a structured questionnaire: Caucasians (Australia, Iceland, Germany, United States), African Americans (United States), Asians (Taiwan), and South Americans (Brazil). Regression analyses and interaction tests were used to assess ethnic and sex differences in relationships between AHI and anthropometric measures (body mass index [BMI], neck circumference, waist circumference) or Mallampati score.Results: Analyses included 1,585 individuals from four ethnic groups: Caucasian (60.6%), African American (17.5%), Asian (13.1%), and South American (8.9%). BMI was most strongly associated with AHI in South Americans (7.8% increase in AHI per 1 kg/m(2) increase in BMI; PConclusions: We demonstrate ethnic and sex variations in associations between obesity and OSA. For similar BMI increases, South American patients show greatest AHI increases compared to African Americans. Findings highlight the importance of considering ethnicity and sex in clinical assessments of OSA risk.

KW - anthropometry

KW - ethnicity

KW - Mallampati score

KW - obesity

KW - obstructive sleep apnea

KW - UPPER AIRWAY

KW - WAIST CIRCUMFERENCE

KW - GENERAL-POPULATION

KW - RESPIRATORY EVENTS

KW - GENDER-DIFFERENCES

KW - GENETIC ANCESTRY

KW - FAT DISTRIBUTION

KW - SEX-DIFFERENCES

KW - ASSOCIATION

KW - OBESITY

U2 - 10.5664/jcsm.7730

DO - 10.5664/jcsm.7730

M3 - Article

VL - 15

SP - 629

EP - 639

JO - Journal of Clincal Sleep Medicine

JF - Journal of Clincal Sleep Medicine

SN - 1550-9389

IS - 4

M1 - PII jc-18-00173

ER -