A genomic study of the glutathione transferase gene family of Arabidopsis thaliana

Pia Gillian Sappl

doi:10.26182/5d5260d9162fa

A genomic study of the glutathione transferase gene family of Arabidopsis thaliana

Pia Gillian Sappl

Research output: Thesis › Doctoral Thesis

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Abstract

[Truncated] Glutathione transferases (GSTs; known formerly as glutathione S-transferases) are an ancient and diverse group of multifunctional proteins that catalyse the conjugation of glutathione to a range of electrophilic substrates. Plant GSTs are induced by diverse biotic and abiotic stimuli and appear to be important in protecting plants against oxidative damage. The role of plant GSTs in xenobiotic metabolism has been well studied with GSTs being involved in the detoxification of organic pollutants, natural toxins and herbicides. In contrast, the multiple roles of GSTs in endogenous plant metabolism are less well defined. A full understanding of all the roles of GSTs relies on global studies that take into account the contributions of all members of a GST family. Here, global approaches, including bioinformatics, transcriptomics and proteomics, were used to characterise the GST multigene family of the model plant species, Arabidopsis thaliana.

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	The University of Western Australia
DOIs	https://doi.org/10.26182/5d5260d9162fa
Publication status	Unpublished - 2006

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Cite this

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AB - [Truncated] Glutathione transferases (GSTs; known formerly as glutathione S-transferases) are an ancient and diverse group of multifunctional proteins that catalyse the conjugation of glutathione to a range of electrophilic substrates. Plant GSTs are induced by diverse biotic and abiotic stimuli and appear to be important in protecting plants against oxidative damage. The role of plant GSTs in xenobiotic metabolism has been well studied with GSTs being involved in the detoxification of organic pollutants, natural toxins and herbicides. In contrast, the multiple roles of GSTs in endogenous plant metabolism are less well defined. A full understanding of all the roles of GSTs relies on global studies that take into account the contributions of all members of a GST family. Here, global approaches, including bioinformatics, transcriptomics and proteomics, were used to characterise the GST multigene family of the model plant species, Arabidopsis thaliana.

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ER -

A genomic study of the glutathione transferase gene family of Arabidopsis thaliana

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