A Genome-Wide Association Meta-Analysis of Attention-Deficit/Hyperactivity Disorder Symptoms in Population-Based Pediatric Cohorts

C.M. Middeldorp; A.R. Hammerschlag; K.G. Ouwens; M.M. Groen-Blokhuis; B. St. Pourcain; C.U. Greven; I. Pappa; C.M.T. Tiesler; Wei Ang; I.M. Nolte; N. Vilor-Tejedor; J. Bacelis; J.L. Ebejer; H. Zhao; G.E. Davies; E.A. Ehli; D.M. Evans; I.O. Fedko; M. Guxens; J.J. Hottenga; J.J. Hudziak; A. Jugessur; J.P. Kemp; E. Krapohl; N.G. Martin; M. Murcia; R. Myhre; J. Ormel; S.M. Ring; M. Standl; E. Stergiakouli; C. Stoltenberg; E. Thiering; N.J. Timpson; M. Trzaskowski; P.J. van der Most; Carol Wang; D.R. Nyholt; S.E. Medland; B. Neale; B. Jacobsson; J. Sunyer; C.A. Hartman; Andrew J.O. Whitehouse; Craig E. Pennell; J. Heinrich; R. Plomin; G. Davey Smith; H. Tiemeier; D. Posthuma; D.I. Boomsma

doi:10.1016/j.jaac.2016.05.025

A Genome-Wide Association Meta-Analysis of Attention-Deficit/Hyperactivity Disorder Symptoms in Population-Based Pediatric Cohorts

C.M. Middeldorp, A.R. Hammerschlag, K.G. Ouwens, M.M. Groen-Blokhuis, B. St. Pourcain, C.U. Greven, I. Pappa, C.M.T. Tiesler, Wei Ang, I.M. Nolte, N. Vilor-Tejedor, J. Bacelis, J.L. Ebejer, H. Zhao, G.E. Davies, E.A. Ehli, D.M. Evans, I.O. Fedko, M. Guxens, J.J. HottengaJ.J. Hudziak, A. Jugessur, J.P. Kemp, E. Krapohl, N.G. Martin, M. Murcia, R. Myhre, J. Ormel, S.M. Ring, M. Standl, E. Stergiakouli, C. Stoltenberg, E. Thiering, N.J. Timpson, M. Trzaskowski, P.J. van der Most, Carol Wang, D.R. Nyholt, S.E. Medland, B. Neale, B. Jacobsson, J. Sunyer, C.A. Hartman, Andrew J.O. Whitehouse, Craig E. Pennell, J. Heinrich, R. Plomin, G. Davey Smith, H. Tiemeier, D. Posthuma, D.I. Boomsma

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Abstract

© 2016 American Academy of Child and Adolescent PsychiatryObjective The aims of this study were to elucidate the influence of common genetic variants on childhood attention-deficit/hyperactivity disorder (ADHD) symptoms, to identify genetic variants that explain its high heritability, and to investigate the genetic overlap of ADHD symptom scores with ADHD diagnosis. Method Within the EArly Genetics and Lifecourse Epidemiology (EAGLE) consortium, genome-wide single nucleotide polymorphisms (SNPs) and ADHD symptom scores were available for 17,666 children (

Original language	English
Pages (from-to)	896-905.e6
Number of pages	10
Journal	Journal of the American Academy of Child and Adolescent Psychiatry
Volume	55
Issue number	10
DOIs	https://doi.org/10.1016/j.jaac.2016.05.025
Publication status	Published - 1 Oct 2016

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10.1016/j.jaac.2016.05.025

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5068552/

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Middeldorp, C. M., Hammerschlag, A. R., Ouwens, K. G., Groen-Blokhuis, M. M., St. Pourcain, B., Greven, C. U., Pappa, I., Tiesler, C. M. T., Ang, W., Nolte, I. M., Vilor-Tejedor, N., Bacelis, J., Ebejer, J. L., Zhao, H., Davies, G. E., Ehli, E. A., Evans, D. M., Fedko, I. O., Guxens, M., ... Boomsma, D. I. (2016). A Genome-Wide Association Meta-Analysis of Attention-Deficit/Hyperactivity Disorder Symptoms in Population-Based Pediatric Cohorts. Journal of the American Academy of Child and Adolescent Psychiatry, 55(10), 896-905.e6. https://doi.org/10.1016/j.jaac.2016.05.025

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abstract = "{\textcopyright} 2016 American Academy of Child and Adolescent PsychiatryObjective The aims of this study were to elucidate the influence of common genetic variants on childhood attention-deficit/hyperactivity disorder (ADHD) symptoms, to identify genetic variants that explain its high heritability, and to investigate the genetic overlap of ADHD symptom scores with ADHD diagnosis. Method Within the EArly Genetics and Lifecourse Epidemiology (EAGLE) consortium, genome-wide single nucleotide polymorphisms (SNPs) and ADHD symptom scores were available for 17,666 children (",

author = "C.M. Middeldorp and A.R. Hammerschlag and K.G. Ouwens and M.M. Groen-Blokhuis and {St. Pourcain}, B. and C.U. Greven and I. Pappa and C.M.T. Tiesler and Wei Ang and I.M. Nolte and N. Vilor-Tejedor and J. Bacelis and J.L. Ebejer and H. Zhao and G.E. Davies and E.A. Ehli and D.M. Evans and I.O. Fedko and M. Guxens and J.J. Hottenga and J.J. Hudziak and A. Jugessur and J.P. Kemp and E. Krapohl and N.G. Martin and M. Murcia and R. Myhre and J. Ormel and S.M. Ring and M. Standl and E. Stergiakouli and C. Stoltenberg and E. Thiering and N.J. Timpson and M. Trzaskowski and {van der Most}, P.J. and Carol Wang and D.R. Nyholt and S.E. Medland and B. Neale and B. Jacobsson and J. Sunyer and C.A. Hartman and Whitehouse, {Andrew J.O.} and Pennell, {Craig E.} and J. Heinrich and R. Plomin and {Davey Smith}, G. and H. Tiemeier and D. Posthuma and D.I. Boomsma",

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Middeldorp, CM, Hammerschlag, AR, Ouwens, KG, Groen-Blokhuis, MM, St. Pourcain, B, Greven, CU, Pappa, I, Tiesler, CMT, Ang, W, Nolte, IM, Vilor-Tejedor, N, Bacelis, J, Ebejer, JL, Zhao, H, Davies, GE, Ehli, EA, Evans, DM, Fedko, IO, Guxens, M, Hottenga, JJ, Hudziak, JJ, Jugessur, A, Kemp, JP, Krapohl, E, Martin, NG, Murcia, M, Myhre, R, Ormel, J, Ring, SM, Standl, M, Stergiakouli, E, Stoltenberg, C, Thiering, E, Timpson, NJ, Trzaskowski, M, van der Most, PJ, Wang, C, Nyholt, DR, Medland, SE, Neale, B, Jacobsson, B, Sunyer, J, Hartman, CA, Whitehouse, AJO, Pennell, CE, Heinrich, J, Plomin, R, Davey Smith, G, Tiemeier, H, Posthuma, D & Boomsma, DI 2016, 'A Genome-Wide Association Meta-Analysis of Attention-Deficit/Hyperactivity Disorder Symptoms in Population-Based Pediatric Cohorts', Journal of the American Academy of Child and Adolescent Psychiatry, vol. 55, no. 10, pp. 896-905.e6. https://doi.org/10.1016/j.jaac.2016.05.025

A Genome-Wide Association Meta-Analysis of Attention-Deficit/Hyperactivity Disorder Symptoms in Population-Based Pediatric Cohorts. / Middeldorp, C.M.; Hammerschlag, A.R.; Ouwens, K.G. et al.
In: Journal of the American Academy of Child and Adolescent Psychiatry, Vol. 55, No. 10, 01.10.2016, p. 896-905.e6.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - A Genome-Wide Association Meta-Analysis of Attention-Deficit/Hyperactivity Disorder Symptoms in Population-Based Pediatric Cohorts

AU - Middeldorp, C.M.

AU - Hammerschlag, A.R.

AU - Ouwens, K.G.

AU - Groen-Blokhuis, M.M.

AU - St. Pourcain, B.

AU - Greven, C.U.

AU - Pappa, I.

AU - Tiesler, C.M.T.

AU - Ang, Wei

AU - Nolte, I.M.

AU - Vilor-Tejedor, N.

AU - Bacelis, J.

AU - Ebejer, J.L.

AU - Zhao, H.

AU - Davies, G.E.

AU - Ehli, E.A.

AU - Evans, D.M.

AU - Fedko, I.O.

AU - Guxens, M.

AU - Hottenga, J.J.

AU - Hudziak, J.J.

AU - Jugessur, A.

AU - Kemp, J.P.

AU - Krapohl, E.

AU - Martin, N.G.

AU - Murcia, M.

AU - Myhre, R.

AU - Ormel, J.

AU - Ring, S.M.

AU - Standl, M.

AU - Stergiakouli, E.

AU - Stoltenberg, C.

AU - Thiering, E.

AU - Timpson, N.J.

AU - Trzaskowski, M.

AU - van der Most, P.J.

AU - Wang, Carol

AU - Nyholt, D.R.

AU - Medland, S.E.

AU - Neale, B.

AU - Jacobsson, B.

AU - Sunyer, J.

AU - Hartman, C.A.

AU - Whitehouse, Andrew J.O.

AU - Pennell, Craig E.

AU - Heinrich, J.

AU - Plomin, R.

AU - Davey Smith, G.

AU - Tiemeier, H.

AU - Posthuma, D.

AU - Boomsma, D.I.

PY - 2016/10/1

Y1 - 2016/10/1

N2 - © 2016 American Academy of Child and Adolescent PsychiatryObjective The aims of this study were to elucidate the influence of common genetic variants on childhood attention-deficit/hyperactivity disorder (ADHD) symptoms, to identify genetic variants that explain its high heritability, and to investigate the genetic overlap of ADHD symptom scores with ADHD diagnosis. Method Within the EArly Genetics and Lifecourse Epidemiology (EAGLE) consortium, genome-wide single nucleotide polymorphisms (SNPs) and ADHD symptom scores were available for 17,666 children (

AB - © 2016 American Academy of Child and Adolescent PsychiatryObjective The aims of this study were to elucidate the influence of common genetic variants on childhood attention-deficit/hyperactivity disorder (ADHD) symptoms, to identify genetic variants that explain its high heritability, and to investigate the genetic overlap of ADHD symptom scores with ADHD diagnosis. Method Within the EArly Genetics and Lifecourse Epidemiology (EAGLE) consortium, genome-wide single nucleotide polymorphisms (SNPs) and ADHD symptom scores were available for 17,666 children (

U2 - 10.1016/j.jaac.2016.05.025

DO - 10.1016/j.jaac.2016.05.025

M3 - Article

C2 - 27663945

SN - 0890-8567

VL - 55

SP - 896-905.e6

JO - Journal of the American Academy of Child and Adolescent Psychiatry

JF - Journal of the American Academy of Child and Adolescent Psychiatry

IS - 10

ER -

A Genome-Wide Association Meta-Analysis of Attention-Deficit/Hyperactivity Disorder Symptoms in Population-Based Pediatric Cohorts

Abstract

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