A Genome-Wide Association Meta-Analysis of Attention-Deficit/Hyperactivity Disorder Symptoms in Population-Based Pediatric Cohorts

C.M. Middeldorp, A.R. Hammerschlag, K.G. Ouwens, M.M. Groen-Blokhuis, B. St. Pourcain, C.U. Greven, I. Pappa, C.M.T. Tiesler, Wei Ang, I.M. Nolte, N. Vilor-Tejedor, J. Bacelis, J.L. Ebejer, H. Zhao, G.E. Davies, E.A. Ehli, D.M. Evans, I.O. Fedko, M. Guxens, J.J. HottengaJ.J. Hudziak, A. Jugessur, J.P. Kemp, E. Krapohl, N.G. Martin, M. Murcia, R. Myhre, J. Ormel, S.M. Ring, M. Standl, E. Stergiakouli, C. Stoltenberg, E. Thiering, N.J. Timpson, M. Trzaskowski, P.J. van der Most, Carol Wang, D.R. Nyholt, S.E. Medland, B. Neale, B. Jacobsson, J. Sunyer, C.A. Hartman, Andrew J.O. Whitehouse, Craig E. Pennell, J. Heinrich, R. Plomin, G. Davey Smith, H. Tiemeier, D. Posthuma, D.I. Boomsma

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Abstract

© 2016 American Academy of Child and Adolescent PsychiatryObjective The aims of this study were to elucidate the influence of common genetic variants on childhood attention-deficit/hyperactivity disorder (ADHD) symptoms, to identify genetic variants that explain its high heritability, and to investigate the genetic overlap of ADHD symptom scores with ADHD diagnosis. Method Within the EArly Genetics and Lifecourse Epidemiology (EAGLE) consortium, genome-wide single nucleotide polymorphisms (SNPs) and ADHD symptom scores were available for 17,666 children (
Original languageEnglish
Pages (from-to)896-905.e6
Number of pages10
JournalJournal of the American Academy of Child and Adolescent Psychiatry
Volume55
Issue number10
DOIs
Publication statusPublished - 2016

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