A Gambian TNF haplotype matches the European HLA-A1,B8,DR3 and Chinese HLA-A33,B58, DR3 haplotypes

Patricia Price; P. Bolitho; A. Jaye; M. Glasson; L.M. Yindom; G. Sirugo; D. Chase; J. Mcdermid; H. Whittle

doi:10.1034/j.1399-0039.2003.00083.x

A Gambian TNF haplotype matches the European HLA-A1,B8,DR3 and Chinese HLA-A33,B58, DR3 haplotypes

Patricia Price, P. Bolitho, A. Jaye, M. Glasson, L.M. Yindom, G. Sirugo, D. Chase, J. Mcdermid, H. Whittle

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

Caucasians carry TNFA-308*2 in the 8.1 ancestral haplotype (AH) (HLA-A1,B8,DR3). In Gambians, TNFA-308*2 occurs without HLA-B8 or -DR3, suggesting an independent effect of TNFA-308 on disease. Hence we sought a segment of the 8.1 AH in Gambians. BAT1 (intron 10)*2 was selected as a specific marker of the haplotype and was found with TNFA-308*2 in Gambians. Samples homozygous at TNFA-308 and BAT1 (intron 10) demonstrated identity between the African TNFA-308*2 haplotype, the 8.1AH and the Asian diabetogenic 58.1AH (HLA-A33,B58,DR3) across a region spanning BAT1, ATP6G, IKBL, LTA, TNFA, LTB, LST-1 and AIF-1 . Conservation of this block in geographically distinct populations suggests a common evolutionary origin and challenges current views of the role of TNFA-308*2 in disease.

Original language	English
Pages (from-to)	72-75
Journal	Tissue Antigens
Volume	62
Issue number	1
DOIs	https://doi.org/10.1034/j.1399-0039.2003.00083.x
Publication status	Published - 2003

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title = "A Gambian TNF haplotype matches the European HLA-A1,B8,DR3 and Chinese HLA-A33,B58, DR3 haplotypes",

abstract = "Caucasians carry TNFA-308*2 in the 8.1 ancestral haplotype (AH) (HLA-A1,B8,DR3). In Gambians, TNFA-308*2 occurs without HLA-B8 or -DR3, suggesting an independent effect of TNFA-308 on disease. Hence we sought a segment of the 8.1 AH in Gambians. BAT1 (intron 10)*2 was selected as a specific marker of the haplotype and was found with TNFA-308*2 in Gambians. Samples homozygous at TNFA-308 and BAT1 (intron 10) demonstrated identity between the African TNFA-308*2 haplotype, the 8.1AH and the Asian diabetogenic 58.1AH (HLA-A33,B58,DR3) across a region spanning BAT1, ATP6G, IKBL, LTA, TNFA, LTB, LST-1 and AIF-1 . Conservation of this block in geographically distinct populations suggests a common evolutionary origin and challenges current views of the role of TNFA-308*2 in disease.",

author = "Patricia Price and P. Bolitho and A. Jaye and M. Glasson and L.M. Yindom and G. Sirugo and D. Chase and J. Mcdermid and H. Whittle",

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doi = "10.1034/j.1399-0039.2003.00083.x",

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T1 - A Gambian TNF haplotype matches the European HLA-A1,B8,DR3 and Chinese HLA-A33,B58, DR3 haplotypes

AU - Price, Patricia

AU - Bolitho, P.

AU - Jaye, A.

AU - Glasson, M.

AU - Yindom, L.M.

AU - Sirugo, G.

AU - Chase, D.

AU - Mcdermid, J.

AU - Whittle, H.

PY - 2003

Y1 - 2003

N2 - Caucasians carry TNFA-308*2 in the 8.1 ancestral haplotype (AH) (HLA-A1,B8,DR3). In Gambians, TNFA-308*2 occurs without HLA-B8 or -DR3, suggesting an independent effect of TNFA-308 on disease. Hence we sought a segment of the 8.1 AH in Gambians. BAT1 (intron 10)*2 was selected as a specific marker of the haplotype and was found with TNFA-308*2 in Gambians. Samples homozygous at TNFA-308 and BAT1 (intron 10) demonstrated identity between the African TNFA-308*2 haplotype, the 8.1AH and the Asian diabetogenic 58.1AH (HLA-A33,B58,DR3) across a region spanning BAT1, ATP6G, IKBL, LTA, TNFA, LTB, LST-1 and AIF-1 . Conservation of this block in geographically distinct populations suggests a common evolutionary origin and challenges current views of the role of TNFA-308*2 in disease.

AB - Caucasians carry TNFA-308*2 in the 8.1 ancestral haplotype (AH) (HLA-A1,B8,DR3). In Gambians, TNFA-308*2 occurs without HLA-B8 or -DR3, suggesting an independent effect of TNFA-308 on disease. Hence we sought a segment of the 8.1 AH in Gambians. BAT1 (intron 10)*2 was selected as a specific marker of the haplotype and was found with TNFA-308*2 in Gambians. Samples homozygous at TNFA-308 and BAT1 (intron 10) demonstrated identity between the African TNFA-308*2 haplotype, the 8.1AH and the Asian diabetogenic 58.1AH (HLA-A33,B58,DR3) across a region spanning BAT1, ATP6G, IKBL, LTA, TNFA, LTB, LST-1 and AIF-1 . Conservation of this block in geographically distinct populations suggests a common evolutionary origin and challenges current views of the role of TNFA-308*2 in disease.

U2 - 10.1034/j.1399-0039.2003.00083.x

DO - 10.1034/j.1399-0039.2003.00083.x

M3 - Article

SN - 0001-2815

VL - 62

SP - 72

EP - 75

JO - Tissue Antigens

JF - Tissue Antigens

IS - 1

ER -

A Gambian TNF haplotype matches the European HLA-A1,B8,DR3 and Chinese HLA-A33,B58, DR3 haplotypes

Abstract

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