A flux-conservative finite difference scheme for the numerical solution of the nonlinear bioheat equation

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Abstract

We present a flux-conservative finite difference (FCFD) scheme for solving the nonlinear (bio)heat transfer in living tissue. The proposed scheme deals with steep gradients in the material properties for malignant and healthy tissues. The method applies directly on the raw medical image data without the need for sophisticated image analysis algorithms to define the interface between tumor and healthy tissues. We extend the classical finite difference (FD) method to cases with high discontinuities in the material properties. We apply meshless kernels, widely used in Smoothed Particle Hydrodynamics (SPH) method, to approximate properties in the off-grid points introduced by the flux-conservative differential operators. The meshless kernels can accurately capture the steep gradients and provide accurate approximations. We solve the governing equations by using an explicit solver. The relatively small time-step applied is counterbalanced by the small computation effort required at each time-step of the proposed scheme. The FCFD method can accurately compute the numerical solution of the bioheat equation even when noise from the image acquisition is present. Results highlight the applicability of the method and its ability to solve tumor ablation simulations directly on the raw image data, without the need to define the interface between malignant and healthy tissues (segmentation) or meshing.

Original languageEnglish
Title of host publicationComputational Biomechanics for Medicine
Subtitle of host publicationMeasurements, Models, and Predictions
EditorsPoul M.F. Nielsen, Adam Wittek, Karol Miller, Barry Doyle, Grand R. Joldes, Martyn P. Nash
PublisherSpringer International Publishing AG
Pages69-81
Number of pages13
ISBN (Electronic)9783319755892
ISBN (Print)9783319755885
DOIs
Publication statusPublished - 14 May 2018
Event20th International Conference on Medical Image Computing and Computer Assisted Intervention 2017 - Quebec City, Quebec, Canada
Duration: 10 Sep 201714 Sep 2017
https://www.miccai2017.org/

Conference

Conference20th International Conference on Medical Image Computing and Computer Assisted Intervention 2017
Abbreviated titleMICCAI 2017
CountryCanada
CityQuebec
Period10/09/1714/09/17
Internet address

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