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We present a flux-conservative finite difference (FCFD) scheme for solving the nonlinear (bio)heat transfer in living tissue. The proposed scheme deals with steep gradients in the material properties for malignant and healthy tissues. The method applies directly on the raw medical image data without the need for sophisticated image analysis algorithms to define the interface between tumor and healthy tissues. We extend the classical finite difference (FD) method to cases with high discontinuities in the material properties. We apply meshless kernels, widely used in Smoothed Particle Hydrodynamics (SPH) method, to approximate properties in the off-grid points introduced by the flux-conservative differential operators. The meshless kernels can accurately capture the steep gradients and provide accurate approximations. We solve the governing equations by using an explicit solver. The relatively small time-step applied is counterbalanced by the small computation effort required at each time-step of the proposed scheme. The FCFD method can accurately compute the numerical solution of the bioheat equation even when noise from the image acquisition is present. Results highlight the applicability of the method and its ability to solve tumor ablation simulations directly on the raw image data, without the need to define the interface between malignant and healthy tissues (segmentation) or meshing.
|Title of host publication||Computational Biomechanics for Medicine|
|Subtitle of host publication||Measurements, Models, and Predictions|
|Editors||Poul M.F. Nielsen, Adam Wittek, Karol Miller, Barry Doyle, Grand R. Joldes, Martyn P. Nash|
|Publisher||Springer International Publishing AG|
|Number of pages||13|
|Publication status||Published - 14 May 2018|
|Event||20th International Conference on Medical Image Computing and Computer Assisted Intervention 2017 - Quebec City, Quebec, Canada|
Duration: 10 Sep 2017 → 14 Sep 2017
|Conference||20th International Conference on Medical Image Computing and Computer Assisted Intervention 2017|
|Abbreviated title||MICCAI 2017|
|Period||10/09/17 → 14/09/17|
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1/01/16 → 30/06/21