A draft network of ligand-receptor-mediated multicellular signalling in human

J.A. Ramilowski, T. Goldberg, J. Harshbarger, E. Kloppman, M. Lizio, V.P. Satagopam, M. Itoh, H. Kawaji, P. Carninci, B. Rost, Alistair Forrest

Research output: Contribution to journalArticle

79 Citations (Scopus)

Abstract

© 2015 Macmillan Publishers Limited. All rights reserved. Cell-to-cell communication across multiple cell types and tissues strictly governs proper functioning of metazoans and extensively relies on interactions between secreted ligands and cell-surface receptors. Herein, we present the first large-scale map of cell-to-cell communication between 144 human primary cell types. We reveal that most cells express tens to hundreds of ligands and receptors to create a highly connected signalling network through multiple ligand-receptor paths. We also observe extensive autocrine signalling with approximately two-thirds of partners possibly interacting on the same cell type. We find that plasma membrane and secreted proteins have the highest cell-type specificity, they are evolutionarily younger than intracellular proteins, and that most receptors had evolved before their ligands. We provide an online tool to interactively query and visualize our networks and demonstrate how this tool can reveal novel cell-to-cell interactions with the prediction that mast cells signal to monoblastic lineages via the CSF1-CSF1R interacting pair.
Original languageEnglish
Pages (from-to)1-12
JournalNature Communications
Volume6
DOIs
Publication statusPublished - 2015

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draft
Ligands
ligands
cells
Cell Communication
Communication
Cell Surface Receptors
Cell membranes
Autocrine Communication
Proteins
Tissue
Mast Cells
communication
Blood Proteins
Membrane Proteins
proteins
Cell Membrane

Cite this

Ramilowski, J. A., Goldberg, T., Harshbarger, J., Kloppman, E., Lizio, M., Satagopam, V. P., ... Forrest, A. (2015). A draft network of ligand-receptor-mediated multicellular signalling in human. Nature Communications, 6, 1-12. https://doi.org/10.1038/ncomms8866
Ramilowski, J.A. ; Goldberg, T. ; Harshbarger, J. ; Kloppman, E. ; Lizio, M. ; Satagopam, V.P. ; Itoh, M. ; Kawaji, H. ; Carninci, P. ; Rost, B. ; Forrest, Alistair. / A draft network of ligand-receptor-mediated multicellular signalling in human. In: Nature Communications. 2015 ; Vol. 6. pp. 1-12.
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Ramilowski, JA, Goldberg, T, Harshbarger, J, Kloppman, E, Lizio, M, Satagopam, VP, Itoh, M, Kawaji, H, Carninci, P, Rost, B & Forrest, A 2015, 'A draft network of ligand-receptor-mediated multicellular signalling in human' Nature Communications, vol. 6, pp. 1-12. https://doi.org/10.1038/ncomms8866

A draft network of ligand-receptor-mediated multicellular signalling in human. / Ramilowski, J.A.; Goldberg, T.; Harshbarger, J.; Kloppman, E.; Lizio, M.; Satagopam, V.P.; Itoh, M.; Kawaji, H.; Carninci, P.; Rost, B.; Forrest, Alistair.

In: Nature Communications, Vol. 6, 2015, p. 1-12.

Research output: Contribution to journalArticle

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Ramilowski JA, Goldberg T, Harshbarger J, Kloppman E, Lizio M, Satagopam VP et al. A draft network of ligand-receptor-mediated multicellular signalling in human. Nature Communications. 2015;6:1-12. https://doi.org/10.1038/ncomms8866