A dorso-ventral gradient of Pax6 in the developing retina suggests a role in topographic map formation

M. Ziman, Jennifer Rodger, S. Lukehurst, D. Hancock, Sarah Dunlop, Lyn Beazley

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Expression of the transcription factor Pax6 was assessed immunohistochemically in embryonic chick retina during retino-tectal map formation. A low dorsal to high ventral gradient was found that correlated with expression of the axonal guidance cue EphB2. Furthermore, transfection of Pax6 into undifferentiated P19 cells up-regulated EphB2. The results raise the possibility that Pax6 is upstream of EphB2 and that its graded expression defines the dorso-ventral axis of the retino-tectal prqjection. (C) 2002 Elsevier Science B.V. All rights reserved.
Original languageEnglish
Pages (from-to)299-302
JournalDevelopmental Brain Research
Volume140
Issue number2
DOIs
Publication statusPublished - 2003

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Cues
Transfection
Retina
Transcription Factors

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title = "A dorso-ventral gradient of Pax6 in the developing retina suggests a role in topographic map formation",
abstract = "Expression of the transcription factor Pax6 was assessed immunohistochemically in embryonic chick retina during retino-tectal map formation. A low dorsal to high ventral gradient was found that correlated with expression of the axonal guidance cue EphB2. Furthermore, transfection of Pax6 into undifferentiated P19 cells up-regulated EphB2. The results raise the possibility that Pax6 is upstream of EphB2 and that its graded expression defines the dorso-ventral axis of the retino-tectal prqjection. (C) 2002 Elsevier Science B.V. All rights reserved.",
author = "M. Ziman and Jennifer Rodger and S. Lukehurst and D. Hancock and Sarah Dunlop and Lyn Beazley",
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A dorso-ventral gradient of Pax6 in the developing retina suggests a role in topographic map formation. / Ziman, M.; Rodger, Jennifer; Lukehurst, S.; Hancock, D.; Dunlop, Sarah; Beazley, Lyn.

In: Developmental Brain Research, Vol. 140, No. 2, 2003, p. 299-302.

Research output: Contribution to journalArticle

TY - JOUR

T1 - A dorso-ventral gradient of Pax6 in the developing retina suggests a role in topographic map formation

AU - Ziman, M.

AU - Rodger, Jennifer

AU - Lukehurst, S.

AU - Hancock, D.

AU - Dunlop, Sarah

AU - Beazley, Lyn

PY - 2003

Y1 - 2003

N2 - Expression of the transcription factor Pax6 was assessed immunohistochemically in embryonic chick retina during retino-tectal map formation. A low dorsal to high ventral gradient was found that correlated with expression of the axonal guidance cue EphB2. Furthermore, transfection of Pax6 into undifferentiated P19 cells up-regulated EphB2. The results raise the possibility that Pax6 is upstream of EphB2 and that its graded expression defines the dorso-ventral axis of the retino-tectal prqjection. (C) 2002 Elsevier Science B.V. All rights reserved.

AB - Expression of the transcription factor Pax6 was assessed immunohistochemically in embryonic chick retina during retino-tectal map formation. A low dorsal to high ventral gradient was found that correlated with expression of the axonal guidance cue EphB2. Furthermore, transfection of Pax6 into undifferentiated P19 cells up-regulated EphB2. The results raise the possibility that Pax6 is upstream of EphB2 and that its graded expression defines the dorso-ventral axis of the retino-tectal prqjection. (C) 2002 Elsevier Science B.V. All rights reserved.

U2 - 10.1016/S0165-3806(02)00605-3

DO - 10.1016/S0165-3806(02)00605-3

M3 - Article

VL - 140

SP - 299

EP - 302

JO - Developmental Brain Research

JF - Developmental Brain Research

SN - 0165-3806

IS - 2

ER -