A dorso-ventral gradient of Pax6 in the developing retina suggests a role in topographic map formation

M. Ziman, Jennifer Rodger, S. Lukehurst, D. Hancock, Sarah Dunlop, Lyn Beazley

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Expression of the transcription factor Pax6 was assessed immunohistochemically in embryonic chick retina during retino-tectal map formation. A low dorsal to high ventral gradient was found that correlated with expression of the axonal guidance cue EphB2. Furthermore, transfection of Pax6 into undifferentiated P19 cells up-regulated EphB2. The results raise the possibility that Pax6 is upstream of EphB2 and that its graded expression defines the dorso-ventral axis of the retino-tectal prqjection. (C) 2002 Elsevier Science B.V. All rights reserved.
Original languageEnglish
Pages (from-to)299-302
JournalDevelopmental Brain Research
Volume140
Issue number2
DOIs
Publication statusPublished - 2003

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