A dorso-ventral gradient of Pax6 in the developing retina suggests a role in topographic map formation

M. Ziman; Jennifer Rodger; S. Lukehurst; D. Hancock; Sarah Dunlop; Lyn Beazley

doi:10.1016/S0165-3806(02)00605-3

A dorso-ventral gradient of Pax6 in the developing retina suggests a role in topographic map formation

M. Ziman, Jennifer Rodger, S. Lukehurst, D. Hancock, Sarah Dunlop, Lyn Beazley

Institute of Advanced Studies

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

Expression of the transcription factor Pax6 was assessed immunohistochemically in embryonic chick retina during retino-tectal map formation. A low dorsal to high ventral gradient was found that correlated with expression of the axonal guidance cue EphB2. Furthermore, transfection of Pax6 into undifferentiated P19 cells up-regulated EphB2. The results raise the possibility that Pax6 is upstream of EphB2 and that its graded expression defines the dorso-ventral axis of the retino-tectal prqjection. (C) 2002 Elsevier Science B.V. All rights reserved.

Original language	English
Pages (from-to)	299-302
Journal	Developmental Brain Research
Volume	140
Issue number	2
DOIs	https://doi.org/10.1016/S0165-3806(02)00605-3
Publication status	Published - 2003

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title = "A dorso-ventral gradient of Pax6 in the developing retina suggests a role in topographic map formation",

abstract = "Expression of the transcription factor Pax6 was assessed immunohistochemically in embryonic chick retina during retino-tectal map formation. A low dorsal to high ventral gradient was found that correlated with expression of the axonal guidance cue EphB2. Furthermore, transfection of Pax6 into undifferentiated P19 cells up-regulated EphB2. The results raise the possibility that Pax6 is upstream of EphB2 and that its graded expression defines the dorso-ventral axis of the retino-tectal prqjection. (C) 2002 Elsevier Science B.V. All rights reserved.",

author = "M. Ziman and Jennifer Rodger and S. Lukehurst and D. Hancock and Sarah Dunlop and Lyn Beazley",

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T1 - A dorso-ventral gradient of Pax6 in the developing retina suggests a role in topographic map formation

AU - Ziman, M.

AU - Rodger, Jennifer

AU - Lukehurst, S.

AU - Hancock, D.

AU - Dunlop, Sarah

AU - Beazley, Lyn

PY - 2003

Y1 - 2003

N2 - Expression of the transcription factor Pax6 was assessed immunohistochemically in embryonic chick retina during retino-tectal map formation. A low dorsal to high ventral gradient was found that correlated with expression of the axonal guidance cue EphB2. Furthermore, transfection of Pax6 into undifferentiated P19 cells up-regulated EphB2. The results raise the possibility that Pax6 is upstream of EphB2 and that its graded expression defines the dorso-ventral axis of the retino-tectal prqjection. (C) 2002 Elsevier Science B.V. All rights reserved.

AB - Expression of the transcription factor Pax6 was assessed immunohistochemically in embryonic chick retina during retino-tectal map formation. A low dorsal to high ventral gradient was found that correlated with expression of the axonal guidance cue EphB2. Furthermore, transfection of Pax6 into undifferentiated P19 cells up-regulated EphB2. The results raise the possibility that Pax6 is upstream of EphB2 and that its graded expression defines the dorso-ventral axis of the retino-tectal prqjection. (C) 2002 Elsevier Science B.V. All rights reserved.

U2 - 10.1016/S0165-3806(02)00605-3

DO - 10.1016/S0165-3806(02)00605-3

M3 - Article

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VL - 140

SP - 299

EP - 302

JO - Developmental Brain Research

JF - Developmental Brain Research

IS - 2

ER -

A dorso-ventral gradient of Pax6 in the developing retina suggests a role in topographic map formation

Abstract

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