A discrete element method for modelling cell mechanics: Application to the simulation of chondrocyte behavior in the growth plate

Grand R. Joldes; George C. Bourantas; Adam Wittek; Karol Miller; David W. Smith; Bruce S. Gardiner

doi:10.1007/978-3-319-75589-2_9

A discrete element method for modelling cell mechanics: Application to the simulation of chondrocyte behavior in the growth plate

Grand R. Joldes, George C. Bourantas, Adam Wittek, Karol Miller, David W. Smith, Bruce S. Gardiner

Research output: Chapter in Book/Conference paper › Chapter › peer-review

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Abstract

In this paper we describe a discrete element method (DEM) framework we have developed for modelling the mechanical behavior of cells and tissues. By using a particle method we are able to simulate mechanical phenomena involved in tissue cell biomechanics (such as extracellular matrix degradation, secretion, growth) which would be very difficult to simulate using a continuum approach. We use the DEM framework to study chondrocyte behavior in the growth plate. Chondrocytes have an important role in the growth of long bones. They produce cartilage on one side of the growth plate, which is gradually replaced by bone. We will model some mechanical aspects of the chondrocyte behavior during two stages of this process.

Original language	English
Title of host publication	Computational Biomechanics for Medicine
Subtitle of host publication	Measurements, Models, and Predictions
Editors	Poul M.F. Nielsen, Adam Wittek, Karol Miller, Barry Doyle, Grand R. Joldes, Martyn P. Nash
Place of Publication	Switzerland
Publisher	Springer International Publishing AG
Pages	93-103
Number of pages	11
ISBN (Electronic)	9783319755892
ISBN (Print)	9783319755885
DOIs	https://doi.org/10.1007/978-3-319-75589-2_9
Publication status	Published - 14 May 2018

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10.1007/978-3-319-75589-2_9

Joldes, et al., 2018 A discrete element method for modelling cell mechanicsAccepted author manuscript, 633 KB

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Joldes, G. R., Bourantas, G. C., Wittek, A., Miller, K., Smith, D. W., & Gardiner, B. S. (2018). A discrete element method for modelling cell mechanics: Application to the simulation of chondrocyte behavior in the growth plate. In P. M. F. Nielsen, A. Wittek, K. Miller, B. Doyle, G. R. Joldes, & M. P. Nash (Eds.), Computational Biomechanics for Medicine: Measurements, Models, and Predictions (pp. 93-103). Springer International Publishing AG. https://doi.org/10.1007/978-3-319-75589-2_9

Joldes, Grand R. ; Bourantas, George C. ; Wittek, Adam et al. / A discrete element method for modelling cell mechanics : Application to the simulation of chondrocyte behavior in the growth plate. Computational Biomechanics for Medicine: Measurements, Models, and Predictions. editor / Poul M.F. Nielsen ; Adam Wittek ; Karol Miller ; Barry Doyle ; Grand R. Joldes ; Martyn P. Nash. Switzerland : Springer International Publishing AG, 2018. pp. 93-103

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abstract = "In this paper we describe a discrete element method (DEM) framework we have developed for modelling the mechanical behavior of cells and tissues. By using a particle method we are able to simulate mechanical phenomena involved in tissue cell biomechanics (such as extracellular matrix degradation, secretion, growth) which would be very difficult to simulate using a continuum approach. We use the DEM framework to study chondrocyte behavior in the growth plate. Chondrocytes have an important role in the growth of long bones. They produce cartilage on one side of the growth plate, which is gradually replaced by bone. We will model some mechanical aspects of the chondrocyte behavior during two stages of this process.",

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Joldes, GR , Bourantas, GC , Wittek, A , Miller, K , Smith, DW & Gardiner, BS 2018, A discrete element method for modelling cell mechanics: Application to the simulation of chondrocyte behavior in the growth plate. in PMF Nielsen, A Wittek, K Miller, B Doyle, GR Joldes & MP Nash (eds), Computational Biomechanics for Medicine: Measurements, Models, and Predictions. Springer International Publishing AG, Switzerland, pp. 93-103. https://doi.org/10.1007/978-3-319-75589-2_9

A discrete element method for modelling cell mechanics: Application to the simulation of chondrocyte behavior in the growth plate. / Joldes, Grand R.; Bourantas, George C.; Wittek, Adam et al.
Computational Biomechanics for Medicine: Measurements, Models, and Predictions. ed. / Poul M.F. Nielsen; Adam Wittek; Karol Miller; Barry Doyle; Grand R. Joldes; Martyn P. Nash. Switzerland: Springer International Publishing AG, 2018. p. 93-103.

Research output: Chapter in Book/Conference paper › Chapter › peer-review

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Joldes GR , Bourantas GC , Wittek A , Miller K , Smith DW, Gardiner BS. A discrete element method for modelling cell mechanics: Application to the simulation of chondrocyte behavior in the growth plate. In Nielsen PMF, Wittek A, Miller K, Doyle B, Joldes GR, Nash MP, editors, Computational Biomechanics for Medicine: Measurements, Models, and Predictions. Switzerland: Springer International Publishing AG. 2018. p. 93-103 doi: 10.1007/978-3-319-75589-2_9

A discrete element method for modelling cell mechanics: Application to the simulation of chondrocyte behavior in the growth plate

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