A discrete element method for modelling cell mechanics: Application to the simulation of chondrocyte behavior in the growth plate

Research output: Chapter in Book/Conference paperChapter

Abstract

In this paper we describe a discrete element method (DEM) framework we have developed for modelling the mechanical behavior of cells and tissues. By using a particle method we are able to simulate mechanical phenomena involved in tissue cell biomechanics (such as extracellular matrix degradation, secretion, growth) which would be very difficult to simulate using a continuum approach. We use the DEM framework to study chondrocyte behavior in the growth plate. Chondrocytes have an important role in the growth of long bones. They produce cartilage on one side of the growth plate, which is gradually replaced by bone. We will model some mechanical aspects of the chondrocyte behavior during two stages of this process.

LanguageEnglish
Title of host publicationComputational Biomechanics for Medicine
Subtitle of host publicationMeasurements, Models, and Predictions
Place of PublicationSwitzerland
PublisherSpringer International Publishing AG
Pages93-103
Number of pages11
ISBN (Electronic)9783319755892
ISBN (Print)9783319755885
DOIs
Publication statusPublished - 14 May 2018

Fingerprint

Growth Plate
Chondrocytes
Mechanics
Finite difference method
Mechanical Phenomena
cells
bones
Bone
simulation
Bone Development
Tissue
biodynamics
Biomechanical Phenomena
secretions
cartilage
Cartilage
Extracellular Matrix
Biomechanics
Bone and Bones
Cells

Cite this

@inbook{6dd5263b1eb0427ba751b237adb5c026,
title = "A discrete element method for modelling cell mechanics: Application to the simulation of chondrocyte behavior in the growth plate",
abstract = "In this paper we describe a discrete element method (DEM) framework we have developed for modelling the mechanical behavior of cells and tissues. By using a particle method we are able to simulate mechanical phenomena involved in tissue cell biomechanics (such as extracellular matrix degradation, secretion, growth) which would be very difficult to simulate using a continuum approach. We use the DEM framework to study chondrocyte behavior in the growth plate. Chondrocytes have an important role in the growth of long bones. They produce cartilage on one side of the growth plate, which is gradually replaced by bone. We will model some mechanical aspects of the chondrocyte behavior during two stages of this process.",
author = "Joldes, {Grand R.} and Bourantas, {George C.} and Adam Wittek and Karol Miller and Smith, {David W.} and Gardiner, {Bruce S.}",
year = "2018",
month = "5",
day = "14",
doi = "10.1007/978-3-319-75589-2_9",
language = "English",
isbn = "9783319755885",
pages = "93--103",
booktitle = "Computational Biomechanics for Medicine",
publisher = "Springer International Publishing AG",
address = "Switzerland",

}

A discrete element method for modelling cell mechanics : Application to the simulation of chondrocyte behavior in the growth plate. / Joldes, Grand R.; Bourantas, George C.; Wittek, Adam; Miller, Karol; Smith, David W.; Gardiner, Bruce S.

Computational Biomechanics for Medicine: Measurements, Models, and Predictions. Switzerland : Springer International Publishing AG, 2018. p. 93-103.

Research output: Chapter in Book/Conference paperChapter

TY - CHAP

T1 - A discrete element method for modelling cell mechanics

T2 - Application to the simulation of chondrocyte behavior in the growth plate

AU - Joldes, Grand R.

AU - Bourantas, George C.

AU - Wittek, Adam

AU - Miller, Karol

AU - Smith, David W.

AU - Gardiner, Bruce S.

PY - 2018/5/14

Y1 - 2018/5/14

N2 - In this paper we describe a discrete element method (DEM) framework we have developed for modelling the mechanical behavior of cells and tissues. By using a particle method we are able to simulate mechanical phenomena involved in tissue cell biomechanics (such as extracellular matrix degradation, secretion, growth) which would be very difficult to simulate using a continuum approach. We use the DEM framework to study chondrocyte behavior in the growth plate. Chondrocytes have an important role in the growth of long bones. They produce cartilage on one side of the growth plate, which is gradually replaced by bone. We will model some mechanical aspects of the chondrocyte behavior during two stages of this process.

AB - In this paper we describe a discrete element method (DEM) framework we have developed for modelling the mechanical behavior of cells and tissues. By using a particle method we are able to simulate mechanical phenomena involved in tissue cell biomechanics (such as extracellular matrix degradation, secretion, growth) which would be very difficult to simulate using a continuum approach. We use the DEM framework to study chondrocyte behavior in the growth plate. Chondrocytes have an important role in the growth of long bones. They produce cartilage on one side of the growth plate, which is gradually replaced by bone. We will model some mechanical aspects of the chondrocyte behavior during two stages of this process.

UR - http://www.scopus.com/inward/record.url?scp=85053521961&partnerID=8YFLogxK

U2 - 10.1007/978-3-319-75589-2_9

DO - 10.1007/978-3-319-75589-2_9

M3 - Chapter

SN - 9783319755885

SP - 93

EP - 103

BT - Computational Biomechanics for Medicine

PB - Springer International Publishing AG

CY - Switzerland

ER -