A discrete element method for modelling cell mechanics: Application to the simulation of chondrocyte behavior in the growth plate

Research output: Chapter in Book/Conference paperChapter

Abstract

In this paper we describe a discrete element method (DEM) framework we have developed for modelling the mechanical behavior of cells and tissues. By using a particle method we are able to simulate mechanical phenomena involved in tissue cell biomechanics (such as extracellular matrix degradation, secretion, growth) which would be very difficult to simulate using a continuum approach. We use the DEM framework to study chondrocyte behavior in the growth plate. Chondrocytes have an important role in the growth of long bones. They produce cartilage on one side of the growth plate, which is gradually replaced by bone. We will model some mechanical aspects of the chondrocyte behavior during two stages of this process.

LanguageEnglish
Title of host publicationComputational Biomechanics for Medicine
Subtitle of host publicationMeasurements, Models, and Predictions
EditorsPoul M.F. Nielsen, Adam Wittek, Karol Miller, Barry Doyle, Grand R. Joldes, Martyn P. Nash
Place of PublicationSwitzerland
PublisherSpringer International Publishing AG
Pages93-103
Number of pages11
ISBN (Electronic)9783319755892
ISBN (Print)9783319755885
DOIs
Publication statusPublished - 14 May 2018

Fingerprint

Growth Plate
Chondrocytes
Mechanics
Finite difference method
Mechanical Phenomena
cells
bones
Bone
simulation
Bone Development
Tissue
biodynamics
Biomechanical Phenomena
secretions
cartilage
Cartilage
Extracellular Matrix
Biomechanics
Bone and Bones
Cells

Cite this

Joldes, G. R., Bourantas, G. C., Wittek, A., Miller, K., Smith, D. W., & Gardiner, B. S. (2018). A discrete element method for modelling cell mechanics: Application to the simulation of chondrocyte behavior in the growth plate. In P. M. F. Nielsen, A. Wittek, K. Miller, B. Doyle, G. R. Joldes, & M. P. Nash (Eds.), Computational Biomechanics for Medicine: Measurements, Models, and Predictions (pp. 93-103). Switzerland: Springer International Publishing AG. https://doi.org/10.1007/978-3-319-75589-2_9
Joldes, Grand R. ; Bourantas, George C. ; Wittek, Adam ; Miller, Karol ; Smith, David W. ; Gardiner, Bruce S. / A discrete element method for modelling cell mechanics : Application to the simulation of chondrocyte behavior in the growth plate. Computational Biomechanics for Medicine: Measurements, Models, and Predictions. editor / Poul M.F. Nielsen ; Adam Wittek ; Karol Miller ; Barry Doyle ; Grand R. Joldes ; Martyn P. Nash. Switzerland : Springer International Publishing AG, 2018. pp. 93-103
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Joldes, GR, Bourantas, GC, Wittek, A, Miller, K, Smith, DW & Gardiner, BS 2018, A discrete element method for modelling cell mechanics: Application to the simulation of chondrocyte behavior in the growth plate. in PMF Nielsen, A Wittek, K Miller, B Doyle, GR Joldes & MP Nash (eds), Computational Biomechanics for Medicine: Measurements, Models, and Predictions. Springer International Publishing AG, Switzerland, pp. 93-103. https://doi.org/10.1007/978-3-319-75589-2_9

A discrete element method for modelling cell mechanics : Application to the simulation of chondrocyte behavior in the growth plate. / Joldes, Grand R.; Bourantas, George C.; Wittek, Adam; Miller, Karol; Smith, David W.; Gardiner, Bruce S.

Computational Biomechanics for Medicine: Measurements, Models, and Predictions. ed. / Poul M.F. Nielsen; Adam Wittek; Karol Miller; Barry Doyle; Grand R. Joldes; Martyn P. Nash. Switzerland : Springer International Publishing AG, 2018. p. 93-103.

Research output: Chapter in Book/Conference paperChapter

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Joldes GR, Bourantas GC, Wittek A, Miller K, Smith DW, Gardiner BS. A discrete element method for modelling cell mechanics: Application to the simulation of chondrocyte behavior in the growth plate. In Nielsen PMF, Wittek A, Miller K, Doyle B, Joldes GR, Nash MP, editors, Computational Biomechanics for Medicine: Measurements, Models, and Predictions. Switzerland: Springer International Publishing AG. 2018. p. 93-103 https://doi.org/10.1007/978-3-319-75589-2_9