A discrete element method for modelling cell mechanics: Application to the simulation of chondrocyte behavior in the growth plate

Research output: Chapter in Book/Conference paperChapter

114 Downloads (Pure)

Abstract

In this paper we describe a discrete element method (DEM) framework we have developed for modelling the mechanical behavior of cells and tissues. By using a particle method we are able to simulate mechanical phenomena involved in tissue cell biomechanics (such as extracellular matrix degradation, secretion, growth) which would be very difficult to simulate using a continuum approach. We use the DEM framework to study chondrocyte behavior in the growth plate. Chondrocytes have an important role in the growth of long bones. They produce cartilage on one side of the growth plate, which is gradually replaced by bone. We will model some mechanical aspects of the chondrocyte behavior during two stages of this process.

Original languageEnglish
Title of host publicationComputational Biomechanics for Medicine
Subtitle of host publicationMeasurements, Models, and Predictions
EditorsPoul M.F. Nielsen, Adam Wittek, Karol Miller, Barry Doyle, Grand R. Joldes, Martyn P. Nash
Place of PublicationSwitzerland
PublisherSpringer International Publishing AG
Pages93-103
Number of pages11
ISBN (Electronic)9783319755892
ISBN (Print)9783319755885
DOIs
Publication statusPublished - 14 May 2018

Fingerprint Dive into the research topics of 'A discrete element method for modelling cell mechanics: Application to the simulation of chondrocyte behavior in the growth plate'. Together they form a unique fingerprint.

Cite this