A diplotype in the lymphotoxin alpha gene is associated with differential expression of LTA mRNA induced by Gram-positive and Gram-negative bacteria

Suzanna Temple; C.M. Almeida; K.Y. Cheong; R.G. Wunderink; Grant Waterer

doi:10.1111/j.1744-313X.2007.00674.x

A diplotype in the lymphotoxin alpha gene is associated with differential expression of LTA mRNA induced by Gram-positive and Gram-negative bacteria

Suzanna Temple, C.M. Almeida, K.Y. Cheong, R.G. Wunderink, Grant Waterer

Graduate Research School

Research output: Contribution to journal › Article › peer-review

4 Citations (Web of Science)

Abstract

We sequenced the lymphotoxin alpha (LTA) promoter and identified LTA10G>A in strong linkage with LTA252G>A and LTA723C>A. Stimulated cells from LTA723AA: LTA252GG:LTA10AA individuals had significantly higher LTA mRNA levels than LTA723CC:LTA252AA:LTA10GG and LTA723AA:LTA252AG:LTA10GA individuals, suggesting that this diplotype may contain a functional polymorphism explaining the observed disease associations with LTA252G>A.

Original language	English
Pages (from-to)	157-160
Journal	International Journal of Immunogenetics
Volume	34
Issue number	3
DOIs	https://doi.org/10.1111/j.1744-313X.2007.00674.x
Publication status	Published - 2007

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10.1111/j.1744-313X.2007.00674.x

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title = "A diplotype in the lymphotoxin alpha gene is associated with differential expression of LTA mRNA induced by Gram-positive and Gram-negative bacteria",

abstract = "We sequenced the lymphotoxin alpha (LTA) promoter and identified LTA10G>A in strong linkage with LTA252G>A and LTA723C>A. Stimulated cells from LTA723AA: LTA252GG:LTA10AA individuals had significantly higher LTA mRNA levels than LTA723CC:LTA252AA:LTA10GG and LTA723AA:LTA252AG:LTA10GA individuals, suggesting that this diplotype may contain a functional polymorphism explaining the observed disease associations with LTA252G>A.",

author = "Suzanna Temple and C.M. Almeida and K.Y. Cheong and R.G. Wunderink and Grant Waterer",

year = "2007",

doi = "10.1111/j.1744-313X.2007.00674.x",

language = "English",

volume = "34",

pages = "157--160",

journal = "International Journal of Immunogenetics",

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publisher = "Wiley-Blackwell",

number = "3",

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TY - JOUR

T1 - A diplotype in the lymphotoxin alpha gene is associated with differential expression of LTA mRNA induced by Gram-positive and Gram-negative bacteria

AU - Temple, Suzanna

AU - Almeida, C.M.

AU - Cheong, K.Y.

AU - Wunderink, R.G.

AU - Waterer, Grant

PY - 2007

Y1 - 2007

N2 - We sequenced the lymphotoxin alpha (LTA) promoter and identified LTA10G>A in strong linkage with LTA252G>A and LTA723C>A. Stimulated cells from LTA723AA: LTA252GG:LTA10AA individuals had significantly higher LTA mRNA levels than LTA723CC:LTA252AA:LTA10GG and LTA723AA:LTA252AG:LTA10GA individuals, suggesting that this diplotype may contain a functional polymorphism explaining the observed disease associations with LTA252G>A.

AB - We sequenced the lymphotoxin alpha (LTA) promoter and identified LTA10G>A in strong linkage with LTA252G>A and LTA723C>A. Stimulated cells from LTA723AA: LTA252GG:LTA10AA individuals had significantly higher LTA mRNA levels than LTA723CC:LTA252AA:LTA10GG and LTA723AA:LTA252AG:LTA10GA individuals, suggesting that this diplotype may contain a functional polymorphism explaining the observed disease associations with LTA252G>A.

U2 - 10.1111/j.1744-313X.2007.00674.x

DO - 10.1111/j.1744-313X.2007.00674.x

M3 - Article

C2 - 17504504

SN - 1744-3121

VL - 34

SP - 157

EP - 160

JO - International Journal of Immunogenetics

JF - International Journal of Immunogenetics

IS - 3

ER -

A diplotype in the lymphotoxin alpha gene is associated with differential expression of LTA mRNA induced by Gram-positive and Gram-negative bacteria

Abstract

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