A concise synthesis of maleic anhydride and maleimide natural products found in Antrodia camphorata

Scott Stewart, Marta Polomska, R.W. Lim

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Abstract

Recently, the natural products maleic anhydride I and maleimides 2 and 3 have been isolated from the mycelium of Antrodia Camphorata, each displaying activity in LLC cell lines. We describe a concise synthesis of each of these natural compounds utilizing C-C cross-coupling methodology, namely, the Negishi and Suzuki reactions. This efficient and high yielding synthesis is convergent lending itself to production of medicinal analogues. (c) 2007 Elsevier Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)2241-2244
JournalTetrahedron Letters
Volume48
Issue number13
DOIs
Publication statusPublished - 2007

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