Recently, the natural products maleic anhydride I and maleimides 2 and 3 have been isolated from the mycelium of Antrodia Camphorata, each displaying activity in LLC cell lines. We describe a concise synthesis of each of these natural compounds utilizing C-C cross-coupling methodology, namely, the Negishi and Suzuki reactions. This efficient and high yielding synthesis is convergent lending itself to production of medicinal analogues. (c) 2007 Elsevier Ltd. All rights reserved.
Stewart, S., Polomska, M., & Lim, R. W. (2007). A concise synthesis of maleic anhydride and maleimide natural products found in Antrodia camphorata. Tetrahedron Letters, 48(13), 2241-2244. https://doi.org/10.1016/j.tetlet.2007.01.169