A Computational Model of Achilles Tendon Adaptive Remodelling

Stuart Richard Young

doi:10.4225/23/59e453e11611f

A Computational Model of Achilles Tendon Adaptive Remodelling

Stuart Richard Young

Research output: Thesis › Master's Thesis

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Abstract

To date there is no basic theoretical framework describing how tendon maintains tissue homeostasis consistent with lhe experimental data, or how tendon adapts to its environmental load conditions.
Based on established biological principles of tendon damage and repair, I develop a dynamic model of tendon homeostasis capable of adaptation. This research shows that for a model soleus musculotendon unit, the model tendon is 'capable' of dynamically adjusting to find an equilibrium tendon geometry, which coincides with minimum metabolic cost of muscle activation. This model presents an exciting first step to understanding the complex process of tendon homeostasis and adaptation In-vivo.

Original language	English
Qualification	Masters
Awarding Institution	The University of Western Australia
Supervisors/Advisors	Gardiner, Bruce, Supervisor Smith, David, Supervisor
Award date	6 Oct 2017
DOIs	https://doi.org/10.4225/23/59e453e11611f
Publication status	Unpublished - 2017

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10.4225/23/59e453e11611f

THESIS - MASTER BY RESEARCH - YOUNG Stuart Richard - 2017
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title = "A Computational Model of Achilles Tendon Adaptive Remodelling",

abstract = "To date there is no basic theoretical framework describing how tendon maintains tissue homeostasis consistent with lhe experimental data, or how tendon adapts to its environmental load conditions.Based on established biological principles of tendon damage and repair, I develop a dynamic model of tendon homeostasis capable of adaptation. This research shows that for a model soleus musculotendon unit, the model tendon is 'capable' of dynamically adjusting to find an equilibrium tendon geometry, which coincides with minimum metabolic cost of muscle activation. This model presents an exciting first step to understanding the complex process of tendon homeostasis and adaptation In-vivo.",

keywords = "Tendon, Collagen, Remodelling, Fibre Homeostasis, Adaptive",

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school = "The University of Western Australia",

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N2 - To date there is no basic theoretical framework describing how tendon maintains tissue homeostasis consistent with lhe experimental data, or how tendon adapts to its environmental load conditions.Based on established biological principles of tendon damage and repair, I develop a dynamic model of tendon homeostasis capable of adaptation. This research shows that for a model soleus musculotendon unit, the model tendon is 'capable' of dynamically adjusting to find an equilibrium tendon geometry, which coincides with minimum metabolic cost of muscle activation. This model presents an exciting first step to understanding the complex process of tendon homeostasis and adaptation In-vivo.

AB - To date there is no basic theoretical framework describing how tendon maintains tissue homeostasis consistent with lhe experimental data, or how tendon adapts to its environmental load conditions.Based on established biological principles of tendon damage and repair, I develop a dynamic model of tendon homeostasis capable of adaptation. This research shows that for a model soleus musculotendon unit, the model tendon is 'capable' of dynamically adjusting to find an equilibrium tendon geometry, which coincides with minimum metabolic cost of muscle activation. This model presents an exciting first step to understanding the complex process of tendon homeostasis and adaptation In-vivo.

KW - Tendon

KW - Collagen

KW - Remodelling

KW - Fibre Homeostasis

KW - Adaptive

U2 - 10.4225/23/59e453e11611f

DO - 10.4225/23/59e453e11611f

M3 - Master's Thesis

ER -

A Computational Model of Achilles Tendon Adaptive Remodelling

Abstract

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