A Computational Model of Achilles Tendon Adaptive Remodelling

Stuart Richard Young

    Research output: ThesisMaster's Thesis

    Abstract

    To date there is no basic theoretical framework describing how tendon maintains tissue homeostasis consistent with lhe experimental data, or how tendon adapts to its environmental load conditions.
    Based on established biological principles of tendon damage and repair, I develop a dynamic model of tendon homeostasis capable of adaptation. This research shows that for a model soleus musculotendon unit, the model tendon is 'capable' of dynamically adjusting to find an equilibrium tendon geometry, which coincides with minimum metabolic cost of muscle activation. This model presents an exciting first step to understanding the complex process of tendon homeostasis and adaptation In-vivo.
    LanguageEnglish
    QualificationMasters
    Awarding Institution
    • The University of Western Australia
    Award date6 Oct 2017
    DOIs
    StateUnpublished - 2017

    Fingerprint

    Tendons
    Tissue homeostasis
    Muscle
    Dynamic models
    Repair
    Chemical activation
    Geometry
    Costs

    Cite this

    @phdthesis{e9f1e6a6710c4fb8b279c9ca207a5939,
    title = "A Computational Model of Achilles Tendon Adaptive Remodelling",
    abstract = "To date there is no basic theoretical framework describing how tendon maintains tissue homeostasis consistent with lhe experimental data, or how tendon adapts to its environmental load conditions.Based on established biological principles of tendon damage and repair, I develop a dynamic model of tendon homeostasis capable of adaptation. This research shows that for a model soleus musculotendon unit, the model tendon is 'capable' of dynamically adjusting to find an equilibrium tendon geometry, which coincides with minimum metabolic cost of muscle activation. This model presents an exciting first step to understanding the complex process of tendon homeostasis and adaptation In-vivo.",
    keywords = "Tendon, Collagen, Remodelling, Fibre Homeostasis, Adaptive",
    author = "Young, {Stuart Richard}",
    year = "2017",
    doi = "10.4225/23/59e453e11611f",
    language = "English",
    school = "The University of Western Australia",

    }

    Young, SR 2017, 'A Computational Model of Achilles Tendon Adaptive Remodelling', Masters, The University of Western Australia. DOI: 10.4225/23/59e453e11611f

    A Computational Model of Achilles Tendon Adaptive Remodelling. / Young, Stuart Richard.

    2017.

    Research output: ThesisMaster's Thesis

    TY - THES

    T1 - A Computational Model of Achilles Tendon Adaptive Remodelling

    AU - Young,Stuart Richard

    PY - 2017

    Y1 - 2017

    N2 - To date there is no basic theoretical framework describing how tendon maintains tissue homeostasis consistent with lhe experimental data, or how tendon adapts to its environmental load conditions.Based on established biological principles of tendon damage and repair, I develop a dynamic model of tendon homeostasis capable of adaptation. This research shows that for a model soleus musculotendon unit, the model tendon is 'capable' of dynamically adjusting to find an equilibrium tendon geometry, which coincides with minimum metabolic cost of muscle activation. This model presents an exciting first step to understanding the complex process of tendon homeostasis and adaptation In-vivo.

    AB - To date there is no basic theoretical framework describing how tendon maintains tissue homeostasis consistent with lhe experimental data, or how tendon adapts to its environmental load conditions.Based on established biological principles of tendon damage and repair, I develop a dynamic model of tendon homeostasis capable of adaptation. This research shows that for a model soleus musculotendon unit, the model tendon is 'capable' of dynamically adjusting to find an equilibrium tendon geometry, which coincides with minimum metabolic cost of muscle activation. This model presents an exciting first step to understanding the complex process of tendon homeostasis and adaptation In-vivo.

    KW - Tendon

    KW - Collagen

    KW - Remodelling

    KW - Fibre Homeostasis

    KW - Adaptive

    U2 - 10.4225/23/59e453e11611f

    DO - 10.4225/23/59e453e11611f

    M3 - Master's Thesis

    ER -