TY - JOUR
T1 - A comprehensive review on the lipid and pleiotropic effects of pitavastatin
AU - Sahebkar, Amirhossein
AU - Kiaie, Nasim
AU - Gorabi, Armita Mahdavi
AU - Mannarino, Massimo R.
AU - Bainaconi, Vanessa
AU - Jamialahmadi, Tannaz
AU - Pirro, Matteo
AU - Banach, Maciej
PY - 2021/11
Y1 - 2021/11
N2 - The 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors, or statins, are administered as first line therapy for hypercholesterolemia, both in primary and secondary prevention. There is a growing body of evidence showing that beyond their lipid-lowering effect, statins have a number of additional beneficial properties. Pitavastatin is a unique lipophilic statin with a strong effect on lowering plasma total cholesterol and triacylglycerol. It has been reported to have pleiotropic effects such as decreasing inflammation and oxidative stress, regulating angiogenesis and osteogenesis, improving endothelial function and arterial stiffness, and reducing tumor progression. Based on the available studies considering the risk of statin-associated muscle symptoms it seems to be also the safest statin. The unique lipid and non-lipid effects of pitavastatin make this molecule a particularly interesting option for the management of different human diseases. In this review, we first summarized the lipid effects of pitavastatin and then strive to unravel the diverse pleiotropic effects of this molecule.
AB - The 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors, or statins, are administered as first line therapy for hypercholesterolemia, both in primary and secondary prevention. There is a growing body of evidence showing that beyond their lipid-lowering effect, statins have a number of additional beneficial properties. Pitavastatin is a unique lipophilic statin with a strong effect on lowering plasma total cholesterol and triacylglycerol. It has been reported to have pleiotropic effects such as decreasing inflammation and oxidative stress, regulating angiogenesis and osteogenesis, improving endothelial function and arterial stiffness, and reducing tumor progression. Based on the available studies considering the risk of statin-associated muscle symptoms it seems to be also the safest statin. The unique lipid and non-lipid effects of pitavastatin make this molecule a particularly interesting option for the management of different human diseases. In this review, we first summarized the lipid effects of pitavastatin and then strive to unravel the diverse pleiotropic effects of this molecule.
KW - Hypercholesterolemia
KW - Inflammation
KW - Pitavastatin
KW - Pleiotropic effects
KW - Statin
UR - http://www.scopus.com/inward/record.url?scp=85115389372&partnerID=8YFLogxK
U2 - 10.1016/j.plipres.2021.101127
DO - 10.1016/j.plipres.2021.101127
M3 - Review article
C2 - 34509516
AN - SCOPUS:85115389372
SN - 0163-7827
VL - 84
JO - Progress in Lipid Research
JF - Progress in Lipid Research
M1 - 101127
ER -
