@article{43e40f770f2f47a7a4a3bb41bb2e44e7,
title = "A Comprehensive Pan-Cancer Molecular Study of Gynecologic and Breast Cancers",
abstract = "We analyzed molecular data on 2,579 tumors from The Cancer Genome Atlas (TCGA) of four gynecological types plus breast. Our aims were to identify shared and unique molecular features, clinically significant subtypes, and potential therapeutic targets. We found 61 somatic copy-number alterations (SCNAs) and 46 significantly mutated genes (SMGs). Eleven SCNAs and 11 SMGs had not been identified in previous TCGA studies of the individual tumor types. We found functionally significant estrogen receptor-regulated long non-coding RNAs (lncRNAs) and gene/lncRNA interaction networks. Pathway analysis identified subtypes with high leukocyte infiltration, raising potential implications for immunotherapy. Using 16 key molecular features, we identified five prognostic subtypes and developed a decision tree that classified patients into the subtypes based on just six features that are assessable in clinical laboratories. By performing molecular analyses of 2,579 TCGA gynecological (OV, UCEC, CESC, and UCS) and breast tumors, Berger et al. identify five prognostic subtypes using 16 key molecular features and propose a decision tree based on six clinically assessable features that classifies patients into the subtypes.",
keywords = "breast cancer, cervical cancer, gynecologic cancer, omics, ovarian cancer, pan-gynecologic, TCGA, The Cancer Genome Atlas, uterine cancer, uterine carcinosarcoma",
author = "{The Cancer Genome Atlas Research Network} and Berger, {Ashton C.} and Anil Korkut and Kanchi, {Rupa S.} and Hegde, {Apurva M.} and Walter Lenoir and Wenbin Liu and Yuexin Liu and Huihui Fan and Hui Shen and Visweswaran Ravikumar and Arvind Rao and Andre Schultz and Xubin Li and Pavel Sumazin and Cecilia Williams and Pieter Mestdagh and Gunaratne, {Preethi H.} and Christina Yau and Reanne Bowlby and Robertson, {A. Gordon} and Tiezzi, {Daniel G.} and Chen Wang and Cherniack, {Andrew D.} and Godwin, {Andrew K.} and Kuderer, {Nicole M.} and Rader, {Janet S.} and Zuna, {Rosemary E.} and Sood, {Anil K.} and Lazar, {Alexander J.} and Ojesina, {Akinyemi I.} and Clement Adebamowo and Adebamowo, {Sally N.} and Baggerly, {Keith A.} and Chen, {Ting Wen} and Chiu, {Hua Sheng} and Steve Lefever and Liang Liu and Karen MacKenzie and Sandra Orsulic and Jason Roszik and Shelley, {Carl Simon} and Qianqian Song and Vellano, {Christopher P.} and Nicolas Wentzensen and Caesar-Johnson, {Samantha J.} and Demchok, {John A.} and Ina Felau and Melpomeni Kasapi and Ferguson, {Martin L.} and Hutter, {Carolyn M.} and Sofia, {Heidi J.} and Roy Tarnuzzer and Zhining Wang and Liming Yang and Zenklusen, {Jean C.} and Zhang, {Jiashan (Julia)} and Sudha Chudamani and Jia Liu and Laxmi Lolla and Rashi Naresh and Todd Pihl and Qiang Sun and Yunhu Wan and Ye Wu and Juok Cho and Timothy DeFreitas and Scott Frazer and Nils Gehlenborg and Gad Getz and Heiman, {David I.} and Jaegil Kim and Lawrence, {Michael S.} and Pei Lin and Sam Meier and Noble, {Michael S.} and Gordon Saksena and Doug Voet and Hailei Zhang and Brady Bernard and Nyasha Chambwe and Varsha Dhankani and Theo Knijnenburg and Roger Kramer and Kalle Leinonen and Michael Miller and Sheila Reynolds and Ilya Shmulevich and Vesteinn Thorsson and Wei Zhang and Rehan Akbani and Broom, {Bradley M.} and Zhenlin Ju and Jun Li and Han Liang and Shiyun Ling and Yiling Lu and Mills, {Gordon B.} and Ng, {Kwok Shing} and Michael Ryan and Jing Wang and Weinstein, {John N.} and Jiexin Zhang and Adam Abeshouse and Joshua Armenia and Debyani Chakravarty and Chatila, {Walid K.} and {de Bruijn}, Ino and Jianjiong Gao and Gross, {Benjamin E.} and Heins, {Zachary J.} and Ritika Kundra and Konnor La and Marc Ladanyi and Augustin Luna and Nissan, {Moriah G.} and Angelica Ochoa and Phillips, {Sarah M.} and Ed Reznik and Francisco Sanchez-Vega and Chris Sander and Nikolaus Schultz and Robert Sheridan and Sumer, {S. Onur} and Yichao Sun and Taylor, {Barry S.} and Pavana Anur and Myron Peto and Paul Spellman and Christopher Benz and Stuart, {Joshua M.} and Wong, {Christopher K.} and Hayes, {D. Neil} and Parker, {Joel S.} and Wilkerson, {Matthew D.} and Adrian Ally and Miruna Balasundaram and Denise Brooks and Rebecca Carlsen and Eric Chuah and Noreen Dhalla and Robert Holt and Jones, {Steven J.M.} and Katayoon Kasaian and Darlene Lee and Yussanne Ma and Marra, {Marco A.} and Michael Mayo and Moore, {Richard A.} and Mungall, {Andrew J.} and Karen Mungall and Sara Sadeghi and Schein, {Jacqueline E.} and Payal Sipahimalani and Angela Tam and Nina Thiessen and Kane Tse and Tina Wong and Rameen Beroukhim and Carrie Cibulskis and Gabriel, {Stacey B.} and Gao, {Galen F.} and Gavin Ha and Matthew Meyerson and Schumacher, {Steven E.} and Juliann Shih and Kucherlapati, {Melanie H.} and Kucherlapati, {Raju S.} and Stephen Baylin and Leslie Cope and Ludmila Danilova and Bootwalla, {Moiz S.} and Lai, {Phillip H.} and Maglinte, {Dennis T.} and {Van Den Berg}, {David J.} and Weisenberger, {Daniel J.} and Auman, {J. Todd} and Saianand Balu and Tom Bodenheimer and Cheng Fan and Hoadley, {Katherine A.} and Hoyle, {Alan P.} and Jefferys, {Stuart R.} and Jones, {Corbin D.} and Shaowu Meng and Mieczkowski, {Piotr A.} and Mose, {Lisle E.} and Perou, {Amy H.} and Perou, {Charles M.} and Jeffrey Roach and Yan Shi and Simons, {Janae V.} and Tara Skelly and Soloway, {Matthew G.} and Donghui Tan and Umadevi Veluvolu and Toshinori Hinoue and Laird, {Peter W.} and Wanding Zhou and Michelle Bellair and Kyle Chang and Kyle Covington and Creighton, {Chad J.} and Huyen Dinh and Doddapaneni, {Harsha Vardhan} and Donehower, {Lawrence A.} and Jennifer Drummond and Gibbs, {Richard A.} and Robert Glenn and Walker Hale and Yi Han and Jianhong Hu and Viktoriya Korchina and Sandra Lee and Lora Lewis and Wei Li and Xiuping Liu and Margaret Morgan and Donna Morton and Donna Muzny and Jireh Santibanez and Margi Sheth and Eve Shinbrot and Linghua Wang and Min Wang and Wheeler, {David A.} and Liu Xi and Fengmei Zhao and Julian Hess and Appelbaum, {Elizabeth L.} and Matthew Bailey and Cordes, {Matthew G.} and Li Ding and Fronick, {Catrina C.} and Fulton, {Lucinda A.} and Fulton, {Robert S.} and Cyriac Kandoth and Mardis, {Elaine R.} and McLellan, {Michael D.} and Miller, {Christopher A.} and Schmidt, {Heather K.} and Wilson, {Richard K.} and Daniel Crain and Erin Curley and Johanna Gardner and Kevin Lau and David Mallery and Scott Morris and Joseph Paulauskis and Robert Penny and Jenette Creaney",
year = "2018",
month = apr,
day = "9",
doi = "10.1016/j.ccell.2018.03.014",
language = "English",
volume = "33",
pages = "690--705.e9",
journal = "Cancer Cell",
issn = "1535-6108",
publisher = "Cell Press",
number = "4",
}