A comparison of the clinical, laboratory and epidemiological features of two divergent subpopulations of Plasmodium knowlesi

Ting Huey Hu; Nawal Rosli; Dayang S.A. Mohamad; Khamisah A. Kadir; Zhen Hao Ching; Yaw Hung Chai; Nur Naqibah Ideris; Linda S.C. Ting; Adeline A. Dihom; Sing Ling Kong; Edmund K.Y. Wong; Jenny E.H. Sia; Tiana Ti; Irene P.F. Chai; Wei Yieng Tang; King Ching Hii; Paul C.S. Divis; Timothy M.E. Davis; Cyrus Daneshvar; Balbir Singh

doi:10.1038/s41598-021-99644-8

A comparison of the clinical, laboratory and epidemiological features of two divergent subpopulations of Plasmodium knowlesi

Ting Huey Hu, Nawal Rosli, Dayang S.A. Mohamad, Khamisah A. Kadir, Zhen Hao Ching, Yaw Hung Chai, Nur Naqibah Ideris, Linda S.C. Ting, Adeline A. Dihom, Sing Ling Kong, Edmund K.Y. Wong, Jenny E.H. Sia, Tiana Ti, Irene P.F. Chai, Wei Yieng Tang, King Ching Hii, Paul C.S. Divis, Timothy M.E. Davis, Cyrus Daneshvar, Balbir Singh

Internal Medicine

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

Plasmodium knowlesi, a simian malaria parasite responsible for all recent indigenous cases of malaria in Malaysia, infects humans throughout Southeast Asia. There are two genetically distinct subpopulations of Plasmodium knowlesi in Malaysian Borneo, one associated with long-tailed macaques (termed cluster 1) and the other with pig-tailed macaques (cluster 2). A prospective study was conducted to determine whether there were any between-subpopulation differences in clinical and laboratory features, as well as in epidemiological characteristics. Over 2 years, 420 adults admitted to Kapit Hospital, Malaysian Borneo with knowlesi malaria were studied. Infections with each subpopulation resulted in mostly uncomplicated malaria. Severe disease was observed in 35/298 (11.7%) of single cluster 1 and 8/115 (7.0%) of single cluster 2 infections (p = 0.208). There was no clinically significant difference in outcome between the two subpopulations. Cluster 1 infections were more likely to be associated with peri-domestic activities while cluster 2 were associated with interior forest activities consistent with the preferred habitats of the respective macaque hosts. Infections with both P. knowlesi subpopulations cause a wide spectrum of disease including potentially life-threatening complications, with no implications for differential patient management.

Original language	English
Article number	20117
Journal	Scientific Reports
Volume	11
Issue number	1
DOIs	https://doi.org/10.1038/s41598-021-99644-8
Publication status	Published - Dec 2021

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Hu, T. H., Rosli, N., Mohamad, D. S. A., Kadir, K. A., Ching, Z. H., Chai, Y. H., Ideris, N. N., Ting, L. S. C., Dihom, A. A., Kong, S. L., Wong, E. K. Y., Sia, J. E. H., Ti, T., Chai, I. P. F., Tang, W. Y., Hii, K. C., Divis, P. C. S., Davis, T. M. E., Daneshvar, C., & Singh, B. (2021). A comparison of the clinical, laboratory and epidemiological features of two divergent subpopulations of Plasmodium knowlesi. Scientific Reports, 11(1), Article 20117. https://doi.org/10.1038/s41598-021-99644-8

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title = "A comparison of the clinical, laboratory and epidemiological features of two divergent subpopulations of Plasmodium knowlesi",

abstract = "Plasmodium knowlesi, a simian malaria parasite responsible for all recent indigenous cases of malaria in Malaysia, infects humans throughout Southeast Asia. There are two genetically distinct subpopulations of Plasmodium knowlesi in Malaysian Borneo, one associated with long-tailed macaques (termed cluster 1) and the other with pig-tailed macaques (cluster 2). A prospective study was conducted to determine whether there were any between-subpopulation differences in clinical and laboratory features, as well as in epidemiological characteristics. Over 2 years, 420 adults admitted to Kapit Hospital, Malaysian Borneo with knowlesi malaria were studied. Infections with each subpopulation resulted in mostly uncomplicated malaria. Severe disease was observed in 35/298 (11.7%) of single cluster 1 and 8/115 (7.0%) of single cluster 2 infections (p = 0.208). There was no clinically significant difference in outcome between the two subpopulations. Cluster 1 infections were more likely to be associated with peri-domestic activities while cluster 2 were associated with interior forest activities consistent with the preferred habitats of the respective macaque hosts. Infections with both P. knowlesi subpopulations cause a wide spectrum of disease including potentially life-threatening complications, with no implications for differential patient management.",

author = "Hu, {Ting Huey} and Nawal Rosli and Mohamad, {Dayang S.A.} and Kadir, {Khamisah A.} and Ching, {Zhen Hao} and Chai, {Yaw Hung} and Ideris, {Nur Naqibah} and Ting, {Linda S.C.} and Dihom, {Adeline A.} and Kong, {Sing Ling} and Wong, {Edmund K.Y.} and Sia, {Jenny E.H.} and Tiana Ti and Chai, {Irene P.F.} and Tang, {Wei Yieng} and Hii, {King Ching} and Divis, {Paul C.S.} and Davis, {Timothy M.E.} and Cyrus Daneshvar and Balbir Singh",

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doi = "10.1038/s41598-021-99644-8",

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Hu, TH, Rosli, N, Mohamad, DSA, Kadir, KA, Ching, ZH, Chai, YH, Ideris, NN, Ting, LSC, Dihom, AA, Kong, SL, Wong, EKY, Sia, JEH, Ti, T, Chai, IPF, Tang, WY, Hii, KC, Divis, PCS, Davis, TME, Daneshvar, C & Singh, B 2021, 'A comparison of the clinical, laboratory and epidemiological features of two divergent subpopulations of Plasmodium knowlesi', Scientific Reports, vol. 11, no. 1, 20117. https://doi.org/10.1038/s41598-021-99644-8

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T1 - A comparison of the clinical, laboratory and epidemiological features of two divergent subpopulations of Plasmodium knowlesi

AU - Hu, Ting Huey

AU - Rosli, Nawal

AU - Mohamad, Dayang S.A.

AU - Kadir, Khamisah A.

AU - Ching, Zhen Hao

AU - Chai, Yaw Hung

AU - Ideris, Nur Naqibah

AU - Ting, Linda S.C.

AU - Dihom, Adeline A.

AU - Kong, Sing Ling

AU - Wong, Edmund K.Y.

AU - Sia, Jenny E.H.

AU - Ti, Tiana

AU - Chai, Irene P.F.

AU - Tang, Wei Yieng

AU - Hii, King Ching

AU - Divis, Paul C.S.

AU - Davis, Timothy M.E.

AU - Daneshvar, Cyrus

AU - Singh, Balbir

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AB - Plasmodium knowlesi, a simian malaria parasite responsible for all recent indigenous cases of malaria in Malaysia, infects humans throughout Southeast Asia. There are two genetically distinct subpopulations of Plasmodium knowlesi in Malaysian Borneo, one associated with long-tailed macaques (termed cluster 1) and the other with pig-tailed macaques (cluster 2). A prospective study was conducted to determine whether there were any between-subpopulation differences in clinical and laboratory features, as well as in epidemiological characteristics. Over 2 years, 420 adults admitted to Kapit Hospital, Malaysian Borneo with knowlesi malaria were studied. Infections with each subpopulation resulted in mostly uncomplicated malaria. Severe disease was observed in 35/298 (11.7%) of single cluster 1 and 8/115 (7.0%) of single cluster 2 infections (p = 0.208). There was no clinically significant difference in outcome between the two subpopulations. Cluster 1 infections were more likely to be associated with peri-domestic activities while cluster 2 were associated with interior forest activities consistent with the preferred habitats of the respective macaque hosts. Infections with both P. knowlesi subpopulations cause a wide spectrum of disease including potentially life-threatening complications, with no implications for differential patient management.

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JO - Scientific Reports

JF - Scientific Reports

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ER -

A comparison of the clinical, laboratory and epidemiological features of two divergent subpopulations of Plasmodium knowlesi

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