A comparison of hemodynamic metrics and intraluminal thrombus burden in a common iliac artery aneurysm

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Abstract

Aneurysms of the common iliac artery (CIAA) are typically found in association with an abdominal aortic aneurysm (AAA). Isolated CIAAs, in the absence of an AAA, are uncommon. Similar to AAAs, CIAA may develop intraluminal thrombus (ILT). As isolated CIAAs have a contralateral common iliac artery for comparison, they provide an opportunity to study the hemodynamic mechanisms behind ILT formation.

In this study, we compared a large isolated CIAA and the contralateral iliac artery using computational fluid dynamics to determine if hemodynamic metrics correlate with the location of ILT. We performed a comprehensive computational fluid dynamics study and investigated the residence time of platelets and monocytes, velocity fields, time-averaged wall shear stress, oscillatory shear index, and endothelial cell activation potential. We then correlated these data to ILT burden determined with computed tomography.

We found that high cell residence times, low time-averaged wall shear stress, high oscillatory shear index, and high endothelial cell activation potential all correlate with regions of ILT development. Our results show agreement with previous hypotheses of thrombus formation in AAA and provide insights into the computational hemodynamics of iliac artery aneurysms.
Original languageEnglish
Title of host publicationInternational Journal for Numerical Methods in Biomedical Engineering
EditorsPerumal Nithiarasu, Rainald Löhner, Guowei Wei
PublisherJohn Wiley & Sons
ISBN (Electronic)2040-7947
DOIs
Publication statusE-pub ahead of print - 1 Jan 2016
Event4TH INTERNATIONAL CONFERENCE ONCOMPUTATIONAL & MATHEMATICAL BIOMEDICAL ENGINEERING 2015: CMBE15 - France, France, France
Duration: 29 Jun 20151 Jul 2015
http://www.compbiomed.net/2015/

Conference

Conference4TH INTERNATIONAL CONFERENCE ONCOMPUTATIONAL & MATHEMATICAL BIOMEDICAL ENGINEERING 2015
Abbreviated titleCMBE15
CountryFrance
CityFrance
Period29/06/151/07/15
Internet address

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Cite this

Kelsey, L. J., Powell, J. T., Norman, P. E., Miller, K., & Doyle, B. J. (2016). A comparison of hemodynamic metrics and intraluminal thrombus burden in a common iliac artery aneurysm. In P. Nithiarasu, R. Löhner, & G. Wei (Eds.), International Journal for Numerical Methods in Biomedical Engineering [e02821] John Wiley & Sons. https://doi.org/10.1002/cnm.2821