@article{563f186d037141608011ad9c1f418423,
title = "A Community-Driven, Openly Accessible Molecular Pathway Integrating Knowledge on Malignant Pleural Mesothelioma",
abstract = "Malignant pleural mesothelioma (MPM) is a highly aggressive malignancy mainly triggered by exposure to asbestos and characterized by complex biology. A significant body of knowledge has been generated over the decades by the research community which has improved our understanding of the disease toward prevention, diagnostic opportunities and new treatments. Omics technologies are opening for additional levels of information and hypotheses. Given the growing complexity and technological spread of biological knowledge in MPM, there is an increasing need for an integrating tool that may allow scientists to access the information and analyze data in a simple and interactive way. We envisioned that a platform to capture this widespread and fast-growing body of knowledge in a machine-readable and simple visual format together with tools for automated large-scale data analysis could be an important support for the work of the general scientist in MPM and for the community to share, critically discuss, distribute and eventually advance scientific results. Toward this goal, with the support of experts in the field and informed by existing literature, we have developed the first version of a molecular pathway model of MPM in the biological pathway database WikiPathways. This provides a visual and interactive overview of interactions and connections between the most central genes, proteins and molecular pathways known to be involved or altered in MPM. Currently, 455 unique genes and 247 interactions are included, derived after stringent manual curation of an initial 39 literature references. The pathway model provides a directly employable research tool with links to common databases and repositories for the exploration and the analysis of omics data. The resource is publicly available in the WikiPathways database (Wikipathways : WP5087) and continues to be under development and curation by the community, enabling the scientists in MPM to actively participate in the prioritization of shared biological knowledge.",
keywords = "BAP1, cancer, disease map, malignant pleural mesothelioma (MPM), pathway modelling, WikiPathways",
author = "Marvin Martens and Franziska Kreidl and Friederike Ehrhart and Didier Jean and Merlin Mei and Mortensen, {Holly M.} and Alistair Nash and Penny Nymark and Evelo, {Chris T.} and Ferdinando Cerciello",
note = "Funding Information: This project has received funding from the European Union{\textquoteright}s Horizon 2020 research and innovation programme under grant agreement No 681002 (EU-ToxRisk) and under the EJP RD COFUND-EJP No 825575. This work was funded by VHP4Safety – the Virtual Human Platform for safety assessment project NWA 1292.19.272. This project has received funding from Inserm, the Marlies Schwegler Foundation, and the Swedish fund for Research without Animals (N2020-0005). This work was supported by the US Environmental Protection Agency National Program in Chemistry Safety and Sustainability, Adverse Outcome Pathway, 4.3.2: Computational modeling approaches and case study validation to identify genetic-based susceptibility factors to environmental chemical exposures. Funding Information: The authors would like to thank (alphabetically): Dr. Jenette Creaney (National Centre for Asbestos Related Disease, Institute of Respiratory Health, University of Western Australia, Australia), Dr. Emanuela Felley-Bosco (Laboratory of Molecular Oncology, Division of Thoracic Surgery, University Hospital Z{\"u}rich, Z{\"u}rich, Switzerland), Dr. Scott A Fisher (National Centre for Asbestos Related Disease, Institute of Respiratory Health, University of Western Australia, Australia), Dr. Marie-Claude Jaurand (Centre de Recherche des Cordeliers, Inserm UMRS-1138, Sorbonne Universit{\'e}, Universit{\'e} de Paris, Functional Genomics of Solid Tumors, Paris, France), Dr. Lydie Lane (CALIPHO Group, SIB Swiss Institute of Bioinformatics and Department of microbiology and molecular medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland), Dr. Amber Louw (National Centre for Asbestos Related Disease, Institute of Respiratory Health, University of Western Australia, Australia) for helpful and critical discussion and for participation to our first mesothelioma WikiPathways workshop. Publisher Copyright: Copyright {\textcopyright} 2022 Martens, Kreidl, Ehrhart, Jean, Mei, Mortensen, Nash, Nymark, Evelo and Cerciello.",
year = "2022",
month = apr,
day = "26",
doi = "10.3389/fonc.2022.849640",
language = "English",
volume = "12",
journal = "Frontiers in Oncology",
issn = "2234-943X",
publisher = "Frontiers Media SA",
}
