A chiral tetrahydro‐γ‐pyranonecarboxylate ester for asymmetric Nazarov cyclization

Charles S Bond, G.A. Leonard, A.C. Regan, W.N. Hunter, J.F.P. Andrews

Research output: Contribution to journalArticlepeer-review

1 Citation (Web of Science)


(1S,2-exo)-1-[(N,N-Dicyclohexylamino)sulfonylme-thyl]-7,7-dimethylbicyclo[2.2.1]heptan-2-yl [2R(2alpha,-3beta,5beta,6alpha)]-tetrahydro-2,5,6-trimethyl-4-oxo-2H-py-ran-3-carboxylate, C31H51NO6S, has an asymmetric unit containing two unique but similarly conformed molecules (A and B). In molecule A the cyclohexyl rings are free to crystallize in either of the approximately coplanar conformations. whereas in molecule B only one conformation is allowed. The N atoms in each molecule have approximately planar geometries, as expected from previous related structures. The tetrahydropyranone ring adopts the chair conformation with all substituents equatorial.
Original languageEnglish
Pages (from-to)133-136
Number of pages4
JournalActa Crystallographica. Section C: Crystal Structure Communications
Publication statusPublished - Jan 1994
Externally publishedYes


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