Projects per year
Abstract
The Staphylococcus aureus Network Adaptive Platform (SNAP) trial is a multifactorial Bayesian adaptive platform trial that aims to improve the way that S. aureus bloodstream infection, a globally common and severe infectious disease, is treated. In a world first, the SNAP trial will simultaneously investigate the effects of multiple intervention modalities within multiple groups of participants with different forms of S. aureus bloodstream infection. Here, we formalise the trial structure, modelling approach, and decision rules that will be used for the SNAP trial. By summarising the statistical principles governing the design, our hope is that the SNAP trial will serve as an adaptable template that can be used to improve comparative effectiveness research efficiency in other disease areas.Trial registration NCT05137119 . Registered on 30 November 2021.
Original language | English |
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Article number | 795 |
Number of pages | 15 |
Journal | Trials |
Volume | 24 |
Issue number | 1 |
DOIs | |
Publication status | Published - 6 Dec 2023 |
Externally published | Yes |
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Dive into the research topics of 'A blueprint for a multi-disease, multi-domain Bayesian adaptive platform trial incorporating adult and paediatric subgroups: the Staphylococcus aureus Network Adaptive Platform trial'. Together they form a unique fingerprint.Projects
- 1 Active
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S. aureus Network Adaptive Platform - Paediatrics & Youth trial (SNAP-PY)
Bowen, A. (Investigator 01), Tong, S. (Investigator 02), Davis, J. (Investigator 03), Campbell, A. (Investigator 04), Snelling, T. (Investigator 05), McGlothlin, A. (Investigator 06), Webb, S. (Investigator 07), Webb, R. (Investigator 08) & Gwee, A. (Investigator 09)
NHMRC National Health and Medical Research Council
1/07/22 → 30/06/27
Project: Research