A Benzoic Acid Derivative and Flavokawains from Piper species as Schistosomiasis Vector Controls

Ludmila N. Rapado, Giovana C. Freitas, Adriano Polpo, Maritza Rojas-Cardozo, Javier V. Rincon, Marcus T. Scotti, Massuo J. Kato, Eliana Nakano, Lydia F. Yamaguchi

Research output: Contribution to journalArticle

6 Citations (Scopus)


The search of alternative compounds to control tropical diseases such as schistosomiasis has pointed to secondary metabolites derived from natural sources. Piper species are candidates in strategies to control the transmission of schistosomiasis due to their production of molluscicidal compounds. A new benzoic acid derivative and three flavokawains from Piper diospyrifolium, P. cumanense and P. gaudichaudianum displayed significant activities against Biomphalaria glabrata snails. Additionally, "in silico" studies were performed using docking assays and Molecular Interaction Fields to evaluate the physical-chemical differences among the compounds in order to characterize the observed activities of the test compounds against Biomphalaria glabrata snails.

Original languageEnglish
Pages (from-to)5205-5218
Number of pages14
Issue number4
Publication statusPublished - Apr 2014
Externally publishedYes

Cite this