A Benzoic Acid Derivative and Flavokawains from Piper species as Schistosomiasis Vector Controls

Ludmila N. Rapado; Giovana C. Freitas; Adriano Polpo; Maritza Rojas-Cardozo; Javier V. Rincon; Marcus T. Scotti; Massuo J. Kato; Eliana Nakano; Lydia F. Yamaguchi

doi:10.3390/molecules19045205

A Benzoic Acid Derivative and Flavokawains from Piper species as Schistosomiasis Vector Controls

Ludmila N. Rapado, Giovana C. Freitas, Adriano Polpo, Maritza Rojas-Cardozo, Javier V. Rincon, Marcus T. Scotti, Massuo J. Kato, Eliana Nakano, Lydia F. Yamaguchi

Research output: Contribution to journal › Article › peer-review

11 Citations (Web of Science)

Abstract

The search of alternative compounds to control tropical diseases such as schistosomiasis has pointed to secondary metabolites derived from natural sources. Piper species are candidates in strategies to control the transmission of schistosomiasis due to their production of molluscicidal compounds. A new benzoic acid derivative and three flavokawains from Piper diospyrifolium, P. cumanense and P. gaudichaudianum displayed significant activities against Biomphalaria glabrata snails. Additionally, "in silico" studies were performed using docking assays and Molecular Interaction Fields to evaluate the physical-chemical differences among the compounds in order to characterize the observed activities of the test compounds against Biomphalaria glabrata snails.

Original language	English
Pages (from-to)	5205-5218
Number of pages	14
Journal	Molecules
Volume	19
Issue number	4
DOIs	https://doi.org/10.3390/molecules19045205
Publication status	Published - Apr 2014
Externally published	Yes

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10.3390/molecules19045205

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title = "A Benzoic Acid Derivative and Flavokawains from Piper species as Schistosomiasis Vector Controls",

abstract = "The search of alternative compounds to control tropical diseases such as schistosomiasis has pointed to secondary metabolites derived from natural sources. Piper species are candidates in strategies to control the transmission of schistosomiasis due to their production of molluscicidal compounds. A new benzoic acid derivative and three flavokawains from Piper diospyrifolium, P. cumanense and P. gaudichaudianum displayed significant activities against Biomphalaria glabrata snails. Additionally, {"}in silico{"} studies were performed using docking assays and Molecular Interaction Fields to evaluate the physical-chemical differences among the compounds in order to characterize the observed activities of the test compounds against Biomphalaria glabrata snails.",

keywords = "schistosomiasis, molluscicide, benzoic acid, flavokawain, Piper, NUCLEAR RECEPTOR SUPERFAMILY, BIOMPHALARIA-GLABRATA, INTERMEDIATE, METHYSTICUM",

author = "Rapado, {Ludmila N.} and Freitas, {Giovana C.} and Adriano Polpo and Maritza Rojas-Cardozo and Rincon, {Javier V.} and Scotti, {Marcus T.} and Kato, {Massuo J.} and Eliana Nakano and Yamaguchi, {Lydia F.}",

year = "2014",

month = apr,

doi = "10.3390/molecules19045205",

language = "English",

volume = "19",

pages = "5205--5218",

journal = "Molecules",

issn = "1420-3049",

publisher = "MDPI AG",

number = "4",

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TY - JOUR

T1 - A Benzoic Acid Derivative and Flavokawains from Piper species as Schistosomiasis Vector Controls

AU - Rapado, Ludmila N.

AU - Freitas, Giovana C.

AU - Polpo, Adriano

AU - Rojas-Cardozo, Maritza

AU - Rincon, Javier V.

AU - Scotti, Marcus T.

AU - Kato, Massuo J.

AU - Nakano, Eliana

AU - Yamaguchi, Lydia F.

PY - 2014/4

Y1 - 2014/4

N2 - The search of alternative compounds to control tropical diseases such as schistosomiasis has pointed to secondary metabolites derived from natural sources. Piper species are candidates in strategies to control the transmission of schistosomiasis due to their production of molluscicidal compounds. A new benzoic acid derivative and three flavokawains from Piper diospyrifolium, P. cumanense and P. gaudichaudianum displayed significant activities against Biomphalaria glabrata snails. Additionally, "in silico" studies were performed using docking assays and Molecular Interaction Fields to evaluate the physical-chemical differences among the compounds in order to characterize the observed activities of the test compounds against Biomphalaria glabrata snails.

AB - The search of alternative compounds to control tropical diseases such as schistosomiasis has pointed to secondary metabolites derived from natural sources. Piper species are candidates in strategies to control the transmission of schistosomiasis due to their production of molluscicidal compounds. A new benzoic acid derivative and three flavokawains from Piper diospyrifolium, P. cumanense and P. gaudichaudianum displayed significant activities against Biomphalaria glabrata snails. Additionally, "in silico" studies were performed using docking assays and Molecular Interaction Fields to evaluate the physical-chemical differences among the compounds in order to characterize the observed activities of the test compounds against Biomphalaria glabrata snails.

KW - schistosomiasis

KW - molluscicide

KW - benzoic acid

KW - flavokawain

KW - Piper

KW - NUCLEAR RECEPTOR SUPERFAMILY

KW - BIOMPHALARIA-GLABRATA

KW - INTERMEDIATE

KW - METHYSTICUM

U2 - 10.3390/molecules19045205

DO - 10.3390/molecules19045205

M3 - Article

SN - 1420-3049

VL - 19

SP - 5205

EP - 5218

JO - Molecules

JF - Molecules

IS - 4

ER -

A Benzoic Acid Derivative and Flavokawains from Piper species as Schistosomiasis Vector Controls

Abstract

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